A6T9H1 (PQQC_KLEP7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrroloquinoline-quinone synthase
EC=1.3.3.11

Alternative name(s):
Coenzyme PQQ synthesis protein C
Pyrroloquinoline quinone biosynthesis protein C

Gene names

Name:	pqqC
Ordered Locus Names:	KPN78578_17810
ORF Names:	KPN_01811

Organism

Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [Complete proteome] [HAMAP]

Taxonomic identifier

272620 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ By similarity. HAMAP MF_00654
Catalytic activity	6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O. HAMAP MF_00654
Pathway	Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis. HAMAP MF_00654
Sequence similarities	Belongs to the pqqC family.

Ontologies

Keywords
Biological process	PQQ biosynthesis
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	pyrroloquinoline quinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pyrroloquinoline-quinone synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 251

251

Pyrroloquinoline-quinone synthase HAMAP MF_00654

PRO_1000061670

Secondary structure

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251

Helix Strand Turn

Details...

Helix

9 – 18

10

Helix

24 – 26

3

Helix

28 – 34

7

Helix

40 – 43

4

Helix

47 – 66

20

Helix

71 – 84

14

Helix

95 – 99

5

Helix

108 – 112

5

Helix

122 – 134

13

Helix

137 – 142

6

Helix

143 – 148

6

Helix

150 – 164

15

Helix

174 – 188

15

Helix

192 – 197

6

Helix

201 – 229

29

Turn

235 – 239

5

Sequences

	Sequence		Length	Mass (Da)
	A6T9H1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 62122408784C8EB3	FASTA	251	29,030
	10 20 30 40 50 60 MLITDTLSPQ AFEEALRAKG DFYHIHHPYH IAMHNGNATR EQIQGWVANR FYYQTTIPLK 70 80 90 100 110 120 DAAIMANCPD AQTRRKWVQR ILDHDGSHGE DGGIEAWLRL GEAVGLSRDD LLSERHVLPG 130 140 150 160 170 180 VRFAVDAYLN FARRACWQEA ACSSLTELFA PQIHQSRLDS WPQHYPWIKE EGYFYFRSRL 190 200 210 220 230 240 SQANRDVEHG LALAKAYCDS AEKQNRMLEI LQFKLDILWS MLDAMTMAYA LQRPPYHTVT 250 DKAAWHTTRL V

References

[1]	The Klebsiella pneumonia Genome Sequencing Project McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700721 / MGH 78578.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

CP000647 Genomic DNA. Translation: ABR77242.1.

RefSeq

YP_001335472.1. NC_009648.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3HLX	X-ray	1.30	A/D	1-251	[»]
3HML	X-ray	2.35	A/B	1-251	[»]
3HNH	X-ray	1.80	A	1-251	[»]

ProteinModelPortal

A6T9H1.

SMR

A6T9H1. Positions 1-251.

ModBase

Search...

Protein-protein interaction databases

STRING

A6T9H1.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

5342367.

GenomeReviews

Gene locus KPN78578_17810 in contig CP000647_GR.

KEGG

kpn:KPN_01811.

PATRIC

20457904. VBIKlePne13394_1840.

Organism-specific databases

CMR

Search...

Phylogenomic databases

eggNOG

COG5424.

HOGENOM

HBG288944.

OMA

DSWPQHY.

ProtClustDB

PRK05157.

Family and domain databases

HAMAP

MF_00654. PQQ_syn_PqqC.
[Tree]

InterPro

IPR016084. Haem_Oase-like_multi-hlx.
IPR011845. PQQ_synth_PqqC.
IPR004305. TENA/THI4/PQQ_synthPqqC_dom.
[Graphical view]

Gene3D

G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.

KO

K06137.

Pfam

PF03070. TENA_THI-4. 1 hit.
[Graphical view]

SUPFAM

SSF48613. Heme_oxygenase. 1 hit.

TIGRFAMs

TIGR02111. PQQ_syn_pqqC. 1 hit.

ProtoNet

Search...

Entry information

Entry name

PQQC_KLEP7

Accession

Primary (citable) accession number: A6T9H1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	August 21, 2007
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program