ID   UXAB_KLEP7              Reviewed;         483 AA.
AC   A6T900;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   27-MAR-2024, entry version 82.
DE   RecName: Full=Altronate oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00670};
DE            EC=1.1.1.58 {ECO:0000255|HAMAP-Rule:MF_00670};
DE   AltName: Full=Tagaturonate dehydrogenase {ECO:0000255|HAMAP-Rule:MF_00670};
DE   AltName: Full=Tagaturonate reductase {ECO:0000255|HAMAP-Rule:MF_00670};
GN   Name=uxaB {ECO:0000255|HAMAP-Rule:MF_00670};
GN   OrderedLocusNames=KPN78578_16100; ORFNames=KPN_01640;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-altronate + NAD(+) = H(+) + keto-D-tagaturonate + NADH;
CC         Xref=Rhea:RHEA:17813, ChEBI:CHEBI:15378, ChEBI:CHEBI:17360,
CC         ChEBI:CHEBI:17886, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.58;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00670};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00670}.
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family. UxaB
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00670}.
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DR   EMBL; CP000647; ABR77071.1; -; Genomic_DNA.
DR   RefSeq; WP_015958391.1; NC_009648.1.
DR   AlphaFoldDB; A6T900; -.
DR   SMR; A6T900; -.
DR   STRING; 272620.KPN_01640; -.
DR   PaxDb; 272620-KPN_01640; -.
DR   EnsemblBacteria; ABR77071; ABR77071; KPN_01640.
DR   KEGG; kpn:KPN_01640; -.
DR   HOGENOM; CLU_027324_1_0_6; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0009026; F:tagaturonate reductase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   HAMAP; MF_00670; Altron_oxidoreduct; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR023668; Altronate_OxRdtase.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR30524:SF0; ALTRONATE OXIDOREDUCTASE-RELATED; 1.
DR   PANTHER; PTHR30524; MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE; 1.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   CHAIN           1..483
FT                   /note="Altronate oxidoreductase"
FT                   /id="PRO_1000044706"
FT   BINDING         18..29
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00670"
SQ   SEQUENCE   483 AA;  54042 MW;  41BA1BF5D4B90137 CRC64;
     MKTLNRRDFP GAQYPDRIIQ FGEGNFLRAF VDWQIDLLNE HTDLNAGIVV VRPIATDFPP
     SLNTQDGLYT TIIRGLNEQG EAVSDARLIR SVNREISAYA DFDAFLRLAH NPEMRFVFSN
     TTEAGISYHA GDRFDDAPPV SYPAKLTRLL FERYQHFAGA ADKGWVIIPC ELIDYNGEAL
     QALVLRYASE WELPQAFITW LTSANTFCST LVDRIVTGYP RDEVAALEAQ TGYKDAFLDT
     AEHFYLFVIQ GPASLAAELR LDKLPLNVRI VDDIKPYKER KVAILNGAHT ALVPVAFQAG
     IDTVGEAMND AEICAFVEKA IYDEIIPVLD LPRDELVSFA SAVTGRFRNP YIKHQLLSIA
     LNGMTKYRTR ILPQLLAGQK AHGALPPRLT FALAALIAFY RGERDGESYP VQDDADWISR
     YQTLWARHRD GQMSTRELVT AVLSVADHWQ QDLSQTPGLV ELVTADLDAI LTCGMRDAVK
     PLC
//