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A6T900 (UXAB_KLEP7) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Altronate oxidoreductase

EC=1.1.1.58
Alternative name(s):
Tagaturonate dehydrogenase
Tagaturonate reductase
Gene names
Name:uxaB
Ordered Locus Names:KPN78578_16100
ORF Names:KPN_01640
OrganismKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [Complete proteome] [HAMAP]
Taxonomic identifier272620 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-altronate + NAD+ = D-tagaturonate + NADH. HAMAP-Rule MF_00670

Pathway

Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP-Rule MF_00670

Sequence similarities

Belongs to the mannitol dehydrogenase family. UxaB subfamily.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

tagaturonate reductase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 483483Altronate oxidoreductase HAMAP-Rule MF_00670
PRO_1000044706

Regions

Nucleotide binding18 – 2912NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A6T900 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 41BA1BF5D4B90137

FASTA48354,042
        10         20         30         40         50         60 
MKTLNRRDFP GAQYPDRIIQ FGEGNFLRAF VDWQIDLLNE HTDLNAGIVV VRPIATDFPP 

        70         80         90        100        110        120 
SLNTQDGLYT TIIRGLNEQG EAVSDARLIR SVNREISAYA DFDAFLRLAH NPEMRFVFSN 

       130        140        150        160        170        180 
TTEAGISYHA GDRFDDAPPV SYPAKLTRLL FERYQHFAGA ADKGWVIIPC ELIDYNGEAL 

       190        200        210        220        230        240 
QALVLRYASE WELPQAFITW LTSANTFCST LVDRIVTGYP RDEVAALEAQ TGYKDAFLDT 

       250        260        270        280        290        300 
AEHFYLFVIQ GPASLAAELR LDKLPLNVRI VDDIKPYKER KVAILNGAHT ALVPVAFQAG 

       310        320        330        340        350        360 
IDTVGEAMND AEICAFVEKA IYDEIIPVLD LPRDELVSFA SAVTGRFRNP YIKHQLLSIA 

       370        380        390        400        410        420 
LNGMTKYRTR ILPQLLAGQK AHGALPPRLT FALAALIAFY RGERDGESYP VQDDADWISR 

       430        440        450        460        470        480 
YQTLWARHRD GQMSTRELVT AVLSVADHWQ QDLSQTPGLV ELVTADLDAI LTCGMRDAVK 


PLC 

« Hide

References

[1]The Klebsiella pneumonia Genome Sequencing Project
McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700721 / MGH 78578.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000647 Genomic DNA. Translation: ABR77071.1.
RefSeqYP_001335301.1. NC_009648.1.

3D structure databases

ProteinModelPortalA6T900.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272620.KPN_01640.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR77071; ABR77071; KPN_01640.
GeneID5339125.
KEGGkpn:KPN_01640.
PATRIC20457560. VBIKlePne13394_1668.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0246.
HOGENOMHOG000029586.
KOK00041.
OMARVIQFGE.
OrthoDBEOG6CVVB8.
ProtClustDBPRK03643.

Enzyme and pathway databases

BioCycKPNE272620:GKDC-1640-MONOMER.
UniPathwayUPA00246.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPMF_00670. Altron_oxidoreduct.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR023668. Altronate_OxRdtase.
IPR013328. DH_multihelical.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUXAB_KLEP7
AccessionPrimary (citable) accession number: A6T900
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways