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A6T8Z6

- GLSA_KLEP7

UniProt

A6T8Z6 - GLSA_KLEP7

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Protein
Glutaminase
Gene
glsA, KPN78578_16060, KPN_01636
Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei66 – 661Substrate By similarity
Binding sitei117 – 1171Substrate By similarity
Binding sitei161 – 1611Substrate By similarity
Binding sitei168 – 1681Substrate By similarity
Binding sitei192 – 1921Substrate By similarity
Binding sitei244 – 2441Substrate By similarity
Binding sitei262 – 2621Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-1636-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase (EC:3.5.1.2)
Gene namesi
Name:glsA
Ordered Locus Names:KPN78578_16060
ORF Names:KPN_01636
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000000265: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308GlutaminaseUniRule annotation
PRO_0000336030Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272620.KPN_01636.

Structurei

3D structure databases

ProteinModelPortaliA6T8Z6.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

A6T8Z6-1 [UniParc]FASTAAdd to Basket

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MATVINNAML EAILAEIRPL IGRGKVADYI PALASVSGDK LGIAISTVDG    50
QHFAAGDAHE RFSIQSISKV LSLVVAMNHY QEEEIWQRVG KDPSGQPFNS 100
LLQLEIEQGK PRNPFINAGA LVVCDMLQSR LSAPRQRMLE IVRRLSGVAD 150
IAYDPVVARS EFEHSARNAA IAWLMKSFGN FHNDVATVLQ NYFHYCSLEM 200
SCVELARTFL FLADRGIAPH LDAPVIAPIQ SRQVNALMMT SGMYQNAGEF 250
AWRVGLPAKS GVGGGIVAIV PQEMAIAVWS PELDDAGNSL AGVAMLEKLT 300
QRMGRSVF 308
Length:308
Mass (Da):33,521
Last modified:May 20, 2008 - v2
Checksum:i850BB719F80BF0FA
GO

Sequence cautioni

The sequence ABR77067.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR77067.1. Different initiation.
RefSeqiYP_001335297.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR77067; ABR77067; KPN_01636.
GeneIDi5339050.
KEGGikpn:KPN_01636.
PATRICi20457552. VBIKlePne13394_1664.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR77067.1 . Different initiation.
RefSeqi YP_001335297.1. NC_009648.1.

3D structure databases

ProteinModelPortali A6T8Z6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272620.KPN_01636.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR77067 ; ABR77067 ; KPN_01636 .
GeneIDi 5339050.
KEGGi kpn:KPN_01636.
PATRICi 20457552. VBIKlePne13394_1664.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci KPNE272620:GKDC-1636-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700721 / MGH 78578.

Entry informationi

Entry nameiGLSA_KLEP7
AccessioniPrimary (citable) accession number: A6T8Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 40 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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