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A6T8Z6

- GLSA_KLEP7

UniProt

A6T8Z6 - GLSA_KLEP7

Protein

Glutaminase

Gene

glsA

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei66 – 661SubstrateUniRule annotation
    Binding sitei117 – 1171SubstrateUniRule annotation
    Binding sitei161 – 1611SubstrateUniRule annotation
    Binding sitei168 – 1681SubstrateUniRule annotation
    Binding sitei192 – 1921SubstrateUniRule annotation
    Binding sitei244 – 2441SubstrateUniRule annotation
    Binding sitei262 – 2621Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. glutaminase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciKPNE272620:GKDC-1636-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
    Gene namesi
    Name:glsAUniRule annotation
    Ordered Locus Names:KPN78578_16060
    ORF Names:KPN_01636
    OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
    Taxonomic identifieri272620 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308GlutaminasePRO_0000336030Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272620.KPN_01636.

    Structurei

    3D structure databases

    ProteinModelPortaliA6T8Z6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutaminase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2066.
    HOGENOMiHOG000216890.
    KOiK01425.
    OrthoDBiEOG6N94BK.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    HAMAPiMF_00313. Glutaminase.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view]
    PANTHERiPTHR12544. PTHR12544. 1 hit.
    PfamiPF04960. Glutaminase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
    ProtoNetiSearch...

    Sequencei

    Sequence statusi: Complete.

    A6T8Z6-1 [UniParc]FASTAAdd to Basket

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    MATVINNAML EAILAEIRPL IGRGKVADYI PALASVSGDK LGIAISTVDG    50
    QHFAAGDAHE RFSIQSISKV LSLVVAMNHY QEEEIWQRVG KDPSGQPFNS 100
    LLQLEIEQGK PRNPFINAGA LVVCDMLQSR LSAPRQRMLE IVRRLSGVAD 150
    IAYDPVVARS EFEHSARNAA IAWLMKSFGN FHNDVATVLQ NYFHYCSLEM 200
    SCVELARTFL FLADRGIAPH LDAPVIAPIQ SRQVNALMMT SGMYQNAGEF 250
    AWRVGLPAKS GVGGGIVAIV PQEMAIAVWS PELDDAGNSL AGVAMLEKLT 300
    QRMGRSVF 308
    Length:308
    Mass (Da):33,521
    Last modified:May 20, 2008 - v2
    Checksum:i850BB719F80BF0FA
    GO

    Sequence cautioni

    The sequence ABR77067.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000647 Genomic DNA. Translation: ABR77067.1. Different initiation.
    RefSeqiYP_001335297.1. NC_009648.1.

    Genome annotation databases

    EnsemblBacteriaiABR77067; ABR77067; KPN_01636.
    GeneIDi5339050.
    KEGGikpn:KPN_01636.
    PATRICi20457552. VBIKlePne13394_1664.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000647 Genomic DNA. Translation: ABR77067.1 . Different initiation.
    RefSeqi YP_001335297.1. NC_009648.1.

    3D structure databases

    ProteinModelPortali A6T8Z6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272620.KPN_01636.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR77067 ; ABR77067 ; KPN_01636 .
    GeneIDi 5339050.
    KEGGi kpn:KPN_01636.
    PATRICi 20457552. VBIKlePne13394_1664.

    Phylogenomic databases

    eggNOGi COG2066.
    HOGENOMi HOG000216890.
    KOi K01425.
    OrthoDBi EOG6N94BK.

    Enzyme and pathway databases

    BioCyci KPNE272620:GKDC-1636-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    HAMAPi MF_00313. Glutaminase.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view ]
    PANTHERi PTHR12544. PTHR12544. 1 hit.
    Pfami PF04960. Glutaminase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700721 / MGH 78578.

    Entry informationi

    Entry nameiGLSA_KLEP7
    AccessioniPrimary (citable) accession number: A6T8Z6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 41 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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