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A6T8N3

- FOLM_KLEP7

UniProt

A6T8N3 - FOLM_KLEP7

Protein

Dihydrofolate reductase FolM

Gene

folM

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the reduction of dihydrofolate to tetrahydrofolate.By similarity

    Catalytic activityi

    5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei152 – 1521Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. dihydrofolate reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. one-carbon metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciKPNE272620:GKDC-1523-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydrofolate reductase FolM (EC:1.5.1.3)
    Short name:
    DHFR
    Gene namesi
    Name:folM
    Ordered Locus Names:KPN78578_14930
    ORF Names:KPN_01523
    OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
    Taxonomic identifieri272620 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
    ProteomesiUP000000265: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 240240Dihydrofolate reductase FolMPRO_0000339398Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272620.KPN_01523.

    Structurei

    3D structure databases

    ProteinModelPortaliA6T8N3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1028.
    KOiK13938.
    OMAiMKIAPGE.
    OrthoDBiEOG6WDSG3.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6T8N3-1 [UniParc]FASTAAdd to Basket

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    MAEQQPRPIL ITGAGRRIGL ALAHHFLQQR QPVIVSYRTP YPAIDGLREA    50
    GALCLQADFS SDDGILTFAE AVKSHTDGLR AIIHNASDWM AEKPGVPLST 100
    VINRMMQIHV HAPYLLNHAL EALLRGHGHA ASDIIHITDY VVERGSDKHI 150
    AYAASKAALD NMTRSFARKL APEVKVNAIA PSLIMFNEGD DEAYRQQALD 200
    KSLMKIAPGE KEISDLIDYL FTSRYVTGRS FAVDGGRPLR 240
    Length:240
    Mass (Da):26,418
    Last modified:August 21, 2007 - v1
    Checksum:iADDC4B3252A4DC75
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000647 Genomic DNA. Translation: ABR76954.1.
    RefSeqiYP_001335184.1. NC_009648.1.

    Genome annotation databases

    EnsemblBacteriaiABR76954; ABR76954; KPN_01523.
    GeneIDi5338641.
    KEGGikpn:KPN_01523.
    PATRICi20457314. VBIKlePne13394_1545.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000647 Genomic DNA. Translation: ABR76954.1 .
    RefSeqi YP_001335184.1. NC_009648.1.

    3D structure databases

    ProteinModelPortali A6T8N3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272620.KPN_01523.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR76954 ; ABR76954 ; KPN_01523 .
    GeneIDi 5338641.
    KEGGi kpn:KPN_01523.
    PATRICi 20457314. VBIKlePne13394_1545.

    Phylogenomic databases

    eggNOGi COG1028.
    KOi K13938.
    OMAi MKIAPGE.
    OrthoDBi EOG6WDSG3.

    Enzyme and pathway databases

    BioCyci KPNE272620:GKDC-1523-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700721 / MGH 78578.

    Entry informationi

    Entry nameiFOLM_KLEP7
    AccessioniPrimary (citable) accession number: A6T8N3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3