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A6T8N3

- FOLM_KLEP7

UniProt

A6T8N3 - FOLM_KLEP7

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Protein
Dihydrofolate reductase FolM
Gene
folM, KPN78578_14930, KPN_01523
Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reduction of dihydrofolate to tetrahydrofolate By similarity.

Catalytic activityi

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei152 – 1521Proton acceptor By similarity

GO - Molecular functioni

  1. dihydrofolate reductase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. one-carbon metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-1523-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrofolate reductase FolM (EC:1.5.1.3)
Short name:
DHFR
Gene namesi
Name:folM
Ordered Locus Names:KPN78578_14930
ORF Names:KPN_01523
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000000265: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Dihydrofolate reductase FolM
PRO_0000339398Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272620.KPN_01523.

Structurei

3D structure databases

ProteinModelPortaliA6T8N3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
KOiK13938.
OMAiMKIAPGE.
OrthoDBiEOG6WDSG3.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6T8N3-1 [UniParc]FASTAAdd to Basket

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MAEQQPRPIL ITGAGRRIGL ALAHHFLQQR QPVIVSYRTP YPAIDGLREA    50
GALCLQADFS SDDGILTFAE AVKSHTDGLR AIIHNASDWM AEKPGVPLST 100
VINRMMQIHV HAPYLLNHAL EALLRGHGHA ASDIIHITDY VVERGSDKHI 150
AYAASKAALD NMTRSFARKL APEVKVNAIA PSLIMFNEGD DEAYRQQALD 200
KSLMKIAPGE KEISDLIDYL FTSRYVTGRS FAVDGGRPLR 240
Length:240
Mass (Da):26,418
Last modified:August 21, 2007 - v1
Checksum:iADDC4B3252A4DC75
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR76954.1.
RefSeqiYP_001335184.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR76954; ABR76954; KPN_01523.
GeneIDi5338641.
KEGGikpn:KPN_01523.
PATRICi20457314. VBIKlePne13394_1545.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR76954.1 .
RefSeqi YP_001335184.1. NC_009648.1.

3D structure databases

ProteinModelPortali A6T8N3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272620.KPN_01523.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR76954 ; ABR76954 ; KPN_01523 .
GeneIDi 5338641.
KEGGi kpn:KPN_01523.
PATRICi 20457314. VBIKlePne13394_1545.

Phylogenomic databases

eggNOGi COG1028.
KOi K13938.
OMAi MKIAPGE.
OrthoDBi EOG6WDSG3.

Enzyme and pathway databases

BioCyci KPNE272620:GKDC-1523-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700721 / MGH 78578.

Entry informationi

Entry nameiFOLM_KLEP7
AccessioniPrimary (citable) accession number: A6T8N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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