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A6T8N3 (FOLM_KLEP7) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydrofolate reductase FolM

Short name=DHFR
EC=1.5.1.3
Gene names
Name:folM
Ordered Locus Names:KPN78578_14930
ORF Names:KPN_01523
OrganismKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [Complete proteome] [HAMAP]
Taxonomic identifier272620 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reduction of dihydrofolate to tetrahydrofolate By similarity.

Catalytic activity

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family. FolM subfamily.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processone-carbon metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiondihydrofolate reductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 240240Dihydrofolate reductase FolM
PRO_0000339398

Sites

Active site1521Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
A6T8N3 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: ADDC4B3252A4DC75

FASTA24026,418
        10         20         30         40         50         60 
MAEQQPRPIL ITGAGRRIGL ALAHHFLQQR QPVIVSYRTP YPAIDGLREA GALCLQADFS 

        70         80         90        100        110        120 
SDDGILTFAE AVKSHTDGLR AIIHNASDWM AEKPGVPLST VINRMMQIHV HAPYLLNHAL 

       130        140        150        160        170        180 
EALLRGHGHA ASDIIHITDY VVERGSDKHI AYAASKAALD NMTRSFARKL APEVKVNAIA 

       190        200        210        220        230        240 
PSLIMFNEGD DEAYRQQALD KSLMKIAPGE KEISDLIDYL FTSRYVTGRS FAVDGGRPLR 

« Hide

References

[1]The Klebsiella pneumonia Genome Sequencing Project
McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700721 / MGH 78578.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000647 Genomic DNA. Translation: ABR76954.1.
RefSeqYP_001335184.1. NC_009648.1.

3D structure databases

ProteinModelPortalA6T8N3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272620.KPN_01523.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR76954; ABR76954; KPN_01523.
GeneID5338641.
KEGGkpn:KPN_01523.
PATRIC20457314. VBIKlePne13394_1545.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1028.
KOK13938.
OMAMKIAPGE.
OrthoDBEOG6WDSG3.

Enzyme and pathway databases

BioCycKPNE272620:GKDC-1523-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFOLM_KLEP7
AccessionPrimary (citable) accession number: A6T8N3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families