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A6T7T5 (ASTD_KLEP7) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-succinylglutamate 5-semialdehyde dehydrogenase
EC=1.2.1.71
Alternative name(s):
Succinylglutamic semialdehyde dehydrogenase
Short name=SGSD
Gene names
Name:astD
Ordered Locus Names:KPN78578_11950
ORF Names:KPN_01223
OrganismKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [Complete proteome] [HAMAP]
Taxonomic identifier272620 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174

Catalytic activity

N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174

Sequence similarities

Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
   Biological processArginine metabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionsuccinylglutamate-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 492492N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174
PRO_1000065758

Regions

Nucleotide binding220 – 2256NAD By similarity

Sites

Active site2431 By similarity
Active site2771 By similarity

Sequences

Sequence LengthMass (Da)Tools
A6T7T5 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 16881A539413F919

FASTA49252,196
        10         20         30         40         50         60 
MSLWINGEWR PGRGPGFSKQ DPVNLKVVWQ GEAADAGQVA EAVAAARQAF PSWARLPFAA 

        70         80         90        100        110        120 
RQAIVEKFAA LLEASKAELT AVIGAETGKP RWEAAGEVTA MINKVAISVK AYHVRTGEQH 

       130        140        150        160        170        180 
SDLPDGAATL RHRPHGVLAV FGPYNFPGHL PNGHIVPALL AGNTVVFKPS ELTPRSGEAV 

       190        200        210        220        230        240 
VKLWQQAGLP AGVLNLVQGG RETGEALSGQ ADIDGLLFTG SSTTGFHLHR QLAGQPQKIL 

       250        260        270        280        290        300 
ALEMGGNNPL IVDDPRDVDA VVHLTIQSAF ITAGQRCTCA RRLLVRRGEA GDAFLSRLVT 

       310        320        330        340        350        360 
VSQRLIPAAW DAEPQPFLGG LISEQAAQKV HQAWLQRVAA GAVTLLEPRL LQAGTSLLTP 

       370        380        390        400        410        420 
GIVDMSDVAN VEDEEVFGPL LGVWRYDTFE EAIALANATR FGLSCGLISP EREKFDRLLL 

       430        440        450        460        470        480 
EARAGIVNWN KPLTGAASTA PFGGTGASGN HRPGAWYAAD YCAWPMASLE SPTLTLPASL 

       490 
SPGLDFLAGE AS

« Hide

References

[1]The Klebsiella pneumonia Genome Sequencing Project
McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700721 / MGH 78578.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000647 Genomic DNA. Translation: ABR76656.1.
RefSeqYP_001334886.1. NC_009648.1.

3D structure databases

ProteinModelPortalA6T7T5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6T7T5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5338809.
GenomeReviewsGene locus KPN78578_11950 in contig CP000647_GR.
KEGGkpn:KPN_01223.
PATRIC20456734. VBIKlePne13394_1255.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHBG752218.
OMAKAYHART.
ProtClustDBCLSK2400673.

Family and domain databases

HAMAPMF_01174. Aldedh_AstD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR017649. SuccinylGlu_semiald_DH_AstD.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK06447.
PANTHERPTHR11699:SF24. PTHR11699:SF24. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR03240. Arg_catab_astD. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASTD_KLEP7
AccessionPrimary (citable) accession number: A6T7T5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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