Reviewed, UniProtKB/Swiss-Prot A6T7R0 (MSRB_KLEP7)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrB
    EC=1.8.4.12
Alternative name(s):
    Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	KPN78578_11700
ORF Names:	KPN_01198

Organism

Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [Complete proteome] [HAMAP]

Taxonomic identifier

272620 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	137 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Cofactor	Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein By similarity. HAMAP MF_01400
Sequence similarities	Belongs to the msrB Met sulfoxide reductase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 137	136	Peptide methionine sulfoxide reductase msrB HAMAP MF_01400		PRO_1000068273
Sites
	Active site	118	1	Nucleophile By similarity
	Metal binding	46	1	Zinc By similarity
	Metal binding	49	1	Zinc By similarity
	Metal binding	95	1	Zinc By similarity
	Metal binding	98	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6T7R0-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 1D6ECACED2F665CC	FASTA	137	15,292
	10 20 30 40 50 60 MANKPTPEEL KNGLSEMQFY VTQHHGTEPP FTGRLLHNKK NGVYHCLVCD APLFNSQTKY 70 80 90 100 110 120 DSGCGWPSFY EPVSAEAIRY LTDNSHGMQR IEIRCGNCDA HLGHVFPDGP QPTGERYCVN 130 SASLSFTDEQ NGEQIKG

References

[1]	McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000647 Genomic DNA. Translation: ABR76631.1.
RefSeq	YP_001334861.1.
3D structure databases
SMR	A6T7R0. Positions 5-128.
ModBase	Search...
Protein-protein interaction databases
STRING	A6T7R0.
Genome annotation databases
GeneID	5339785.
GenomeReviews	Gene locus KPN78578_11700 in contig CP000647_GR.
KEGG	kpn:KPN_01198.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0229.
HOGENOM	HBG715255.
OMA	VEVRCNH.
Family and domain databases
HAMAP	MF_01400. MsrB. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00357. MsrB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_KLEP7

Accession

Primary (citable) accession number: A6T7R0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	August 21, 2007
Last modified:	February 9, 2010
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)