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A6T6J6

- 6PGL_KLEP7

UniProt

A6T6J6 - 6PGL_KLEP7

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Protein

6-phosphogluconolactonase

Gene
pgl, ybhE, KPN78578_07560, KPN_00781
Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate By similarity.UniRule annotation

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 6-phosphogluconolactonase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-781-MONOMER.
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6-P-gluconolactonase
Gene namesi
Name:pgl
Synonyms:ybhE
Ordered Locus Names:KPN78578_07560
ORF Names:KPN_00781
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000000265: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3313316-phosphogluconolactonaseUniRule annotationPRO_0000323499Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272620.KPN_00781.

Structurei

3D structure databases

ProteinModelPortaliA6T6J6.
SMRiA6T6J6. Positions 1-331.

Family & Domainsi

Sequence similaritiesi

Belongs to the cycloisomerase 2 family.

Phylogenomic databases

eggNOGiCOG2706.
HOGENOMiHOG000257418.
KOiK07404.
OrthoDBiEOG615VK7.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_01605. 6P_gluconolactonase.
InterProiIPR022528. 6-phosphogluconolactonase_YbhE.
IPR019405. Lactonase_7-beta_prop.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF10282. Lactonase. 1 hit.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 1 hit.

Sequencei

Sequence statusi: Complete.

A6T6J6-1 [UniParc]FASTAAdd to Basket

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MKQTVYTASP ESQQIHVWSL EADGKLTLVQ VVDAPGQVQP MVVSPNKEFL    50
YVGVRPEFRV LAYRITPDNG ALTFAGEAAL PGSPTHISTD HHGRFVFSAS 100
YNQGCVSVTP LHDGLPGETI TVVEGLEGCH SANISPDNRT LWVPALKQDR 150
ICLFTLSDDG FLSAQEPAEV TTVEGAGPRH MVFHPNQQYG YCVNELNSSI 200
DVWELKDPKG NIECVQTLDM MPPDFSGVRW AADIHITPDG GHLYACDRTA 250
SIITVFSVSE DGSVLAVEGY QPTETQPRGF NLDHSGKYLI AAGQKSHHIA 300
VYDIVGEQGL LQEKGRYAVG QGPMWVVVNA H 331
Length:331
Mass (Da):36,037
Last modified:March 18, 2008 - v2
Checksum:i0D25EBDA862F667B
GO

Sequence cautioni

The sequence ABR76217.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR76217.1. Different initiation.
RefSeqiYP_001334447.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR76217; ABR76217; KPN_00781.
GeneIDi5342074.
KEGGikpn:KPN_00781.
PATRICi20455822. VBIKlePne13394_0802.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR76217.1 . Different initiation.
RefSeqi YP_001334447.1. NC_009648.1.

3D structure databases

ProteinModelPortali A6T6J6.
SMRi A6T6J6. Positions 1-331.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272620.KPN_00781.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR76217 ; ABR76217 ; KPN_00781 .
GeneIDi 5342074.
KEGGi kpn:KPN_00781.
PATRICi 20455822. VBIKlePne13394_0802.

Phylogenomic databases

eggNOGi COG2706.
HOGENOMi HOG000257418.
KOi K07404.
OrthoDBi EOG615VK7.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00409 .
BioCyci KPNE272620:GKDC-781-MONOMER.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
HAMAPi MF_01605. 6P_gluconolactonase.
InterProi IPR022528. 6-phosphogluconolactonase_YbhE.
IPR019405. Lactonase_7-beta_prop.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
Pfami PF10282. Lactonase. 1 hit.
[Graphical view ]
SUPFAMi SSF50974. SSF50974. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700721 / MGH 78578.

Entry informationi

Entry namei6PGL_KLEP7
AccessioniPrimary (citable) accession number: A6T6J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: May 14, 2014
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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