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A6T6J6

- 6PGL_KLEP7

UniProt

A6T6J6 - 6PGL_KLEP7

Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 2 (18 Mar 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.UniRule annotation

    Catalytic activityi

    6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 6-phosphogluconolactonase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Enzyme and pathway databases

    BioCyciKPNE272620:GKDC-781-MONOMER.
    UniPathwayiUPA00115; UER00409.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconolactonaseUniRule annotation (EC:3.1.1.31UniRule annotation)
    Short name:
    6-P-gluconolactonaseUniRule annotation
    Gene namesi
    Name:pglUniRule annotation
    Synonyms:ybhE
    Ordered Locus Names:KPN78578_07560
    ORF Names:KPN_00781
    OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
    Taxonomic identifieri272620 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
    ProteomesiUP000000265: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3313316-phosphogluconolactonasePRO_0000323499Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272620.KPN_00781.

    Structurei

    3D structure databases

    ProteinModelPortaliA6T6J6.
    SMRiA6T6J6. Positions 1-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cycloisomerase 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2706.
    HOGENOMiHOG000257418.
    KOiK07404.
    OrthoDBiEOG615VK7.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    HAMAPiMF_01605. 6P_gluconolactonase.
    InterProiIPR022528. 6-phosphogluconolactonase_YbhE.
    IPR019405. Lactonase_7-beta_prop.
    IPR011045. N2O_reductase_N.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PfamiPF10282. Lactonase. 1 hit.
    [Graphical view]
    SUPFAMiSSF50974. SSF50974. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6T6J6-1 [UniParc]FASTAAdd to Basket

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    MKQTVYTASP ESQQIHVWSL EADGKLTLVQ VVDAPGQVQP MVVSPNKEFL    50
    YVGVRPEFRV LAYRITPDNG ALTFAGEAAL PGSPTHISTD HHGRFVFSAS 100
    YNQGCVSVTP LHDGLPGETI TVVEGLEGCH SANISPDNRT LWVPALKQDR 150
    ICLFTLSDDG FLSAQEPAEV TTVEGAGPRH MVFHPNQQYG YCVNELNSSI 200
    DVWELKDPKG NIECVQTLDM MPPDFSGVRW AADIHITPDG GHLYACDRTA 250
    SIITVFSVSE DGSVLAVEGY QPTETQPRGF NLDHSGKYLI AAGQKSHHIA 300
    VYDIVGEQGL LQEKGRYAVG QGPMWVVVNA H 331
    Length:331
    Mass (Da):36,037
    Last modified:March 18, 2008 - v2
    Checksum:i0D25EBDA862F667B
    GO

    Sequence cautioni

    The sequence ABR76217.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000647 Genomic DNA. Translation: ABR76217.1. Different initiation.
    RefSeqiYP_001334447.1. NC_009648.1.

    Genome annotation databases

    EnsemblBacteriaiABR76217; ABR76217; KPN_00781.
    GeneIDi5342074.
    KEGGikpn:KPN_00781.
    PATRICi20455822. VBIKlePne13394_0802.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000647 Genomic DNA. Translation: ABR76217.1 . Different initiation.
    RefSeqi YP_001334447.1. NC_009648.1.

    3D structure databases

    ProteinModelPortali A6T6J6.
    SMRi A6T6J6. Positions 1-331.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272620.KPN_00781.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR76217 ; ABR76217 ; KPN_00781 .
    GeneIDi 5342074.
    KEGGi kpn:KPN_00781.
    PATRICi 20455822. VBIKlePne13394_0802.

    Phylogenomic databases

    eggNOGi COG2706.
    HOGENOMi HOG000257418.
    KOi K07404.
    OrthoDBi EOG615VK7.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00409 .
    BioCyci KPNE272620:GKDC-781-MONOMER.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    HAMAPi MF_01605. 6P_gluconolactonase.
    InterProi IPR022528. 6-phosphogluconolactonase_YbhE.
    IPR019405. Lactonase_7-beta_prop.
    IPR011045. N2O_reductase_N.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    Pfami PF10282. Lactonase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50974. SSF50974. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700721 / MGH 78578.

    Entry informationi

    Entry namei6PGL_KLEP7
    AccessioniPrimary (citable) accession number: A6T6J6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3