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A6T6C3

- SYQ_KLEP7

UniProt

A6T6C3 - SYQ_KLEP7

Protein

Glutamine--tRNA ligase

Gene

glnS

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei271 – 2711ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutaminyl-tRNA aminoacylation Source: InterPro
    2. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciKPNE272620:GKDC-701-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--tRNA ligaseUniRule annotation (EC:6.1.1.18UniRule annotation)
    Alternative name(s):
    Glutaminyl-tRNA synthetaseUniRule annotation
    Short name:
    GlnRSUniRule annotation
    Gene namesi
    Name:glnSUniRule annotation
    Ordered Locus Names:KPN78578_06830
    ORF Names:KPN_00701
    OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
    Taxonomic identifieri272620 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
    ProteomesiUP000000265: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Glutamine--tRNA ligasePRO_1000016297Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272620.KPN_00701.

    Structurei

    3D structure databases

    ProteinModelPortaliA6T6C3.
    SMRiA6T6C3. Positions 9-549.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi34 – 4411"HIGH" regionAdd
    BLAST
    Motifi268 – 2725"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000259232.
    KOiK01886.
    OMAiSREIYID.
    OrthoDBiEOG6DRPF7.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    2.40.240.10. 2 hits.
    3.40.50.620. 2 hits.
    HAMAPiMF_00126. Gln_tRNA_synth.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR004514. Gln-tRNA-synth.
    IPR022861. Gln_tRNA_ligase_bac.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF50715. SSF50715. 1 hit.
    TIGRFAMsiTIGR00440. glnS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6T6C3-1 [UniParc]FASTAAdd to Basket

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    MSEAEARPTN FIRQIIDEDL ATGKHTTVHT RFPPEPNGYL HIGHAKSICL    50
    NFGIAQDYQG QCNLRFDDTN PVKEDIEYVE SIKNDVQWLG FHWSGDVCYS 100
    SDYFDQLHQY AVELINKGLA YVDELSPDEI REYRGTLKAP GKNSPYRDRS 150
    VEENLALFEK MRSGGFEEGK ACLRAKIDMA SPFIVMRDPV LYRIKFAEHH 200
    QTGNKWCIYP MYDFTHCISD ALEGITHSLC TLEFQDNRRL YDWVLDNISI 250
    PVHPRQYEFS RLNLEYTVMS KRKLNQLVTE KHVEGWDDPR MPTISGLRRR 300
    GYTAESIREF CKRIGVTKQD NTIEMASLES CIREDLNENA PRAMAVIDPV 350
    KLVIENYPQG ESEMVVMPNH PNKPEMGSRE VPFSAEIWID RADFREEANK 400
    QYKRLVLGKE VRLRNAYVIK AERVEKDAEG NITTIFCTYD ADTLSKDPAD 450
    GRKVKGVIHW VSAAHALPVE IRLYDRLFSV PNPGAADDFL AVINPESLVI 500
    KQGYAEPSLA QAEAGKAYQF EREGYFCLDS RYATATNLVF NRTVGLRDTW 550
    AKAGE 555
    Length:555
    Mass (Da):63,612
    Last modified:August 21, 2007 - v1
    Checksum:iC1101074BF9CBDE6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000647 Genomic DNA. Translation: ABR76144.1.
    RefSeqiYP_001334374.1. NC_009648.1.

    Genome annotation databases

    EnsemblBacteriaiABR76144; ABR76144; KPN_00701.
    GeneIDi5338358.
    KEGGikpn:KPN_00701.
    PATRICi20455648. VBIKlePne13394_0722.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000647 Genomic DNA. Translation: ABR76144.1 .
    RefSeqi YP_001334374.1. NC_009648.1.

    3D structure databases

    ProteinModelPortali A6T6C3.
    SMRi A6T6C3. Positions 9-549.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272620.KPN_00701.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR76144 ; ABR76144 ; KPN_00701 .
    GeneIDi 5338358.
    KEGGi kpn:KPN_00701.
    PATRICi 20455648. VBIKlePne13394_0722.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000259232.
    KOi K01886.
    OMAi SREIYID.
    OrthoDBi EOG6DRPF7.

    Enzyme and pathway databases

    BioCyci KPNE272620:GKDC-701-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    2.40.240.10. 2 hits.
    3.40.50.620. 2 hits.
    HAMAPi MF_00126. Gln_tRNA_synth.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR004514. Gln-tRNA-synth.
    IPR022861. Gln_tRNA_ligase_bac.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF50715. SSF50715. 1 hit.
    TIGRFAMsi TIGR00440. glnS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700721 / MGH 78578.

    Entry informationi

    Entry nameiSYQ_KLEP7
    AccessioniPrimary (citable) accession number: A6T6C3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3