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A6T6C3

- SYQ_KLEP7

UniProt

A6T6C3 - SYQ_KLEP7

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Protein
Glutamine--tRNA ligase
Gene
glnS, KPN78578_06830, KPN_00701
Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei271 – 2711ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutaminyl-tRNA aminoacylation Source: InterPro
  2. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-701-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--tRNA ligase (EC:6.1.1.18)
Alternative name(s):
Glutaminyl-tRNA synthetase
Short name:
GlnRS
Gene namesi
Name:glnS
Ordered Locus Names:KPN78578_06830
ORF Names:KPN_00701
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000000265: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Glutamine--tRNA ligaseUniRule annotation
PRO_1000016297Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272620.KPN_00701.

Structurei

3D structure databases

ProteinModelPortaliA6T6C3.
SMRiA6T6C3. Positions 9-549.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi34 – 4411"HIGH" regionUniRule annotation
Add
BLAST
Motifi268 – 2725"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000259232.
KOiK01886.
OMAiSREIYID.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
HAMAPiMF_00126. Gln_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR022861. Gln_tRNA_ligase_bac.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6T6C3-1 [UniParc]FASTAAdd to Basket

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MSEAEARPTN FIRQIIDEDL ATGKHTTVHT RFPPEPNGYL HIGHAKSICL    50
NFGIAQDYQG QCNLRFDDTN PVKEDIEYVE SIKNDVQWLG FHWSGDVCYS 100
SDYFDQLHQY AVELINKGLA YVDELSPDEI REYRGTLKAP GKNSPYRDRS 150
VEENLALFEK MRSGGFEEGK ACLRAKIDMA SPFIVMRDPV LYRIKFAEHH 200
QTGNKWCIYP MYDFTHCISD ALEGITHSLC TLEFQDNRRL YDWVLDNISI 250
PVHPRQYEFS RLNLEYTVMS KRKLNQLVTE KHVEGWDDPR MPTISGLRRR 300
GYTAESIREF CKRIGVTKQD NTIEMASLES CIREDLNENA PRAMAVIDPV 350
KLVIENYPQG ESEMVVMPNH PNKPEMGSRE VPFSAEIWID RADFREEANK 400
QYKRLVLGKE VRLRNAYVIK AERVEKDAEG NITTIFCTYD ADTLSKDPAD 450
GRKVKGVIHW VSAAHALPVE IRLYDRLFSV PNPGAADDFL AVINPESLVI 500
KQGYAEPSLA QAEAGKAYQF EREGYFCLDS RYATATNLVF NRTVGLRDTW 550
AKAGE 555
Length:555
Mass (Da):63,612
Last modified:August 21, 2007 - v1
Checksum:iC1101074BF9CBDE6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR76144.1.
RefSeqiYP_001334374.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR76144; ABR76144; KPN_00701.
GeneIDi5338358.
KEGGikpn:KPN_00701.
PATRICi20455648. VBIKlePne13394_0722.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR76144.1 .
RefSeqi YP_001334374.1. NC_009648.1.

3D structure databases

ProteinModelPortali A6T6C3.
SMRi A6T6C3. Positions 9-549.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272620.KPN_00701.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR76144 ; ABR76144 ; KPN_00701 .
GeneIDi 5338358.
KEGGi kpn:KPN_00701.
PATRICi 20455648. VBIKlePne13394_0722.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000259232.
KOi K01886.
OMAi SREIYID.
OrthoDBi EOG6DRPF7.

Enzyme and pathway databases

BioCyci KPNE272620:GKDC-701-MONOMER.

Family and domain databases

Gene3Di 1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
HAMAPi MF_00126. Gln_tRNA_synth.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR022861. Gln_tRNA_ligase_bac.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF50715. SSF50715. 1 hit.
TIGRFAMsi TIGR00440. glnS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700721 / MGH 78578.

Entry informationi

Entry nameiSYQ_KLEP7
AccessioniPrimary (citable) accession number: A6T6C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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