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A6T661

- A6T661_KLEP7

UniProt

A6T661 - A6T661_KLEP7

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Protein
Submitted name:

Putative cytosine deaminase and related metal-dependent hydrolases

Gene
KPN_00632
Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi56 – 561Iron; via tele nitrogenImported
Metal bindingi58 – 581Iron; via tele nitrogenImported
Metal bindingi209 – 2091Iron; via tele nitrogenImported
Metal bindingi241 – 2411Iron; via tele nitrogenImported
Metal bindingi308 – 3081IronImported

GO - Molecular functioni

  1. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseImported

Keywords - Ligandi

IronImported, Metal-bindingImported

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-632-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Putative cytosine deaminase and related metal-dependent hydrolasesImported
Gene namesi
ORF Names:KPN_00632Imported
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)Imported
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000000265: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi272620.KPN_00632.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JNPX-ray1.85A/B/C/D/E/F1-412[»]
4JNRX-ray2.00A/B/C/D/E/F1-412[»]
4JNSX-ray1.90A/B/C/D/E/F1-412[»]
ProteinModelPortaliA6T661.
SMRiA6T661. Positions 2-404.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0402.
HOGENOMiHOG000184778.
KOiK01485.
OMAiENSIHIC.
OrthoDBiEOG6QG8F9.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
InterProiIPR013108. Amidohydro_3.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
PfamiPF07969. Amidohydro_3. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.

Sequencei

Sequence statusi: Complete.

A6T661-1 [UniParc]FASTAAdd to Basket

« Hide

MKIINARLRR QEALFTLDLQ DGIIHRITAQ AAMQTADAGA IDAQGRLAIP    50
PFVEPHIHLD ATLTAGEPEW NRSGTLFEGI TRWSQRKASI TPEDTRQRAL 100
KTIGMLRDFG VQHVRTHVDV TDPSLAALQA LLAVKQEAAD LIDLQIVAFP 150
QEGIESYPNG RELMTRAIEM GADVVGGIPH YENTRDKGVS SVMFLMDLAQ 200
RYGRLVDVHC DEIDDPQSRF LEVLAEEARV RGMGAQVTAS HTCAMGSYDN 250
AYCSKLFRLL KASGINFISC PTESIHLQGR FDSWPKRRGV TRVAELDRAG 300
INVCFAQDSI QDPWYPLGNG NILRILDAGL HICHMLGYDD LQRCLDFVTD 350
NSARALCLGD NYGLAEGRPA NLLILDAEND YEAVRRQARV LTSIRHGKVI 400
LQREVEHIRY PA 412
Length:412
Mass (Da):45,893
Last modified:August 21, 2007 - v1
Checksum:i86257A0255C92463
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR76082.1.
RefSeqiYP_001334312.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR76082; ABR76082; KPN_00632.
GeneIDi5338725.
KEGGikpn:KPN_00632.
PATRICi20455504. VBIKlePne13394_0657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR76082.1 .
RefSeqi YP_001334312.1. NC_009648.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4JNP X-ray 1.85 A/B/C/D/E/F 1-412 [» ]
4JNR X-ray 2.00 A/B/C/D/E/F 1-412 [» ]
4JNS X-ray 1.90 A/B/C/D/E/F 1-412 [» ]
ProteinModelPortali A6T661.
SMRi A6T661. Positions 2-404.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272620.KPN_00632.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR76082 ; ABR76082 ; KPN_00632 .
GeneIDi 5338725.
KEGGi kpn:KPN_00632.
PATRICi 20455504. VBIKlePne13394_0657.

Phylogenomic databases

eggNOGi COG0402.
HOGENOMi HOG000184778.
KOi K01485.
OMAi ENSIHIC.
OrthoDBi EOG6QG8F9.

Enzyme and pathway databases

BioCyci KPNE272620:GKDC-632-MONOMER.

Family and domain databases

Gene3Di 2.30.40.10. 1 hit.
InterProi IPR013108. Amidohydro_3.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view ]
Pfami PF07969. Amidohydro_3. 1 hit.
[Graphical view ]
SUPFAMi SSF51338. SSF51338. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700721 / MGH 78578.
  2. "Crystal structure of 5-methylcytosine deaminase from Klebsiella pneumoniae subsp. pneumoniae MGH 78578 liganded with 5-fluorocytosine."
    Fedorov A.A., Fedorov E.V., Hitchcock D., Raushel F.M., Almo S.C.
    Submitted (MAR-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH IRON.
  3. "Crystal structure of 5-methylcytosine deaminase from Klebsiella pneumoniae subsp. pneumoniae MGH 78578 liganded with 5-methylcytosine."
    Fedorov A.A., Fedorov E.V., Hitchcock D., Raushel F.M., Almo S.C.
    Submitted (MAR-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) IN COMPLEX WITH IRON.
  4. "Crystal structure of 5-methylcytosine deaminase from Klebsiella pneumoniae subsp. pneumoniae MGH 78578 liganded with phosphonocytosine."
    Fedorov A.A., Fedorov E.V., Hitchcock D., Raushel F.M., Almo S.C.
    Submitted (MAR-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH IRON.

Entry informationi

Entry nameiA6T661_KLEP7
AccessioniPrimary (citable) accession number: A6T661
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: July 9, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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