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A6T661

- A6T661_KLEP7

UniProt

A6T661 - A6T661_KLEP7

Protein
Submitted name:

Putative cytosine deaminase and related metal-dependent hydrolases

Gene

KPN_00632

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi56 – 561Iron; via tele nitrogenImported
    Metal bindingi58 – 581Iron; via tele nitrogenImported
    Metal bindingi209 – 2091Iron; via tele nitrogenImported
    Metal bindingi241 – 2411Iron; via tele nitrogenImported
    Metal bindingi308 – 3081IronImported

    GO - Molecular functioni

    1. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    HydrolaseImported

    Keywords - Ligandi

    IronImported, Metal-bindingImported

    Enzyme and pathway databases

    BioCyciKPNE272620:GKDC-632-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative cytosine deaminase and related metal-dependent hydrolasesImported
    Gene namesi
    ORF Names:KPN_00632Imported
    OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)Imported
    Taxonomic identifieri272620 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
    ProteomesiUP000000265: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi272620.KPN_00632.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4JNPX-ray1.85A/B/C/D/E/F1-412[»]
    4JNRX-ray2.00A/B/C/D/E/F1-412[»]
    4JNSX-ray1.90A/B/C/D/E/F1-412[»]
    ProteinModelPortaliA6T661.
    SMRiA6T661. Positions 2-404.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0402.
    HOGENOMiHOG000184778.
    KOiK01485.
    OMAiENSIHIC.
    OrthoDBiEOG6QG8F9.

    Family and domain databases

    Gene3Di2.30.40.10. 1 hit.
    InterProiIPR013108. Amidohydro_3.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view]
    PfamiPF07969. Amidohydro_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF51338. SSF51338. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    A6T661-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIINARLRR QEALFTLDLQ DGIIHRITAQ AAMQTADAGA IDAQGRLAIP    50
    PFVEPHIHLD ATLTAGEPEW NRSGTLFEGI TRWSQRKASI TPEDTRQRAL 100
    KTIGMLRDFG VQHVRTHVDV TDPSLAALQA LLAVKQEAAD LIDLQIVAFP 150
    QEGIESYPNG RELMTRAIEM GADVVGGIPH YENTRDKGVS SVMFLMDLAQ 200
    RYGRLVDVHC DEIDDPQSRF LEVLAEEARV RGMGAQVTAS HTCAMGSYDN 250
    AYCSKLFRLL KASGINFISC PTESIHLQGR FDSWPKRRGV TRVAELDRAG 300
    INVCFAQDSI QDPWYPLGNG NILRILDAGL HICHMLGYDD LQRCLDFVTD 350
    NSARALCLGD NYGLAEGRPA NLLILDAEND YEAVRRQARV LTSIRHGKVI 400
    LQREVEHIRY PA 412
    Length:412
    Mass (Da):45,893
    Last modified:August 21, 2007 - v1
    Checksum:i86257A0255C92463
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000647 Genomic DNA. Translation: ABR76082.1.
    RefSeqiYP_001334312.1. NC_009648.1.

    Genome annotation databases

    EnsemblBacteriaiABR76082; ABR76082; KPN_00632.
    GeneIDi5338725.
    KEGGikpn:KPN_00632.
    PATRICi20455504. VBIKlePne13394_0657.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000647 Genomic DNA. Translation: ABR76082.1 .
    RefSeqi YP_001334312.1. NC_009648.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4JNP X-ray 1.85 A/B/C/D/E/F 1-412 [» ]
    4JNR X-ray 2.00 A/B/C/D/E/F 1-412 [» ]
    4JNS X-ray 1.90 A/B/C/D/E/F 1-412 [» ]
    ProteinModelPortali A6T661.
    SMRi A6T661. Positions 2-404.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272620.KPN_00632.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR76082 ; ABR76082 ; KPN_00632 .
    GeneIDi 5338725.
    KEGGi kpn:KPN_00632.
    PATRICi 20455504. VBIKlePne13394_0657.

    Phylogenomic databases

    eggNOGi COG0402.
    HOGENOMi HOG000184778.
    KOi K01485.
    OMAi ENSIHIC.
    OrthoDBi EOG6QG8F9.

    Enzyme and pathway databases

    BioCyci KPNE272620:GKDC-632-MONOMER.

    Family and domain databases

    Gene3Di 2.30.40.10. 1 hit.
    InterProi IPR013108. Amidohydro_3.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view ]
    Pfami PF07969. Amidohydro_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51338. SSF51338. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700721 / MGH 78578Imported.
    2. "Crystal structure of 5-methylcytosine deaminase from Klebsiella pneumoniae subsp. pneumoniae MGH 78578 liganded with 5-fluorocytosine."
      Fedorov A.A., Fedorov E.V., Hitchcock D., Raushel F.M., Almo S.C.
      Submitted (MAR-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH IRON.
    3. "Crystal structure of 5-methylcytosine deaminase from Klebsiella pneumoniae subsp. pneumoniae MGH 78578 liganded with 5-methylcytosine."
      Fedorov A.A., Fedorov E.V., Hitchcock D., Raushel F.M., Almo S.C.
      Submitted (MAR-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) IN COMPLEX WITH IRON.
    4. "Crystal structure of 5-methylcytosine deaminase from Klebsiella pneumoniae subsp. pneumoniae MGH 78578 liganded with phosphonocytosine."
      Fedorov A.A., Fedorov E.V., Hitchcock D., Raushel F.M., Almo S.C.
      Submitted (MAR-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH IRON.

    Entry informationi

    Entry nameiA6T661_KLEP7
    AccessioniPrimary (citable) accession number: A6T661
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 21, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3