Reviewed, UniProtKB/Swiss-Prot A6T613 (BETA_KLEP7)

Names and origin

Protein names

Recommended name:
    Choline dehydrogenase
      Short name=CHD
      Short name=CDH
    EC=1.1.99.1

Gene names

Name:	betA
Ordered Locus Names:	KPN78578_05730
ORF Names:	KPN_00584

Organism

Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [Complete proteome] [HAMAP]

Taxonomic identifier

272620 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	554 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity. HAMAP MF_00750
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750
Cofactor	FAD By similarity. HAMAP MF_00750
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750
Sequence similarities	Belongs to the GMC oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro choline dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 554	554	Choline dehydrogenase HAMAP MF_00750		PRO_1000046564
Regions
	Nucleotide binding	4 – 33	30	FAD Probable
Sites
	Active site	473	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6T613-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 004E57E23C2E06AB	FASTA	554	61,550
	10 20 30 40 50 60 MQFDYIIIGA GSAGNVLATR LTEDPNTTVL LLEAGGPDYR FDFRTQMPAA LAYPLQGKRY 70 80 90 100 110 120 NWAYETEPEP YMNNRRMECG RGKGLGGSSL INGMCYIRGN AMDLDNWAKE PGLEHWSYLD 130 140 150 160 170 180 CLPYYRKAET RDIGPNDYHG GDGPVSVTTP KPGNNPLFEA MVEAGVQAGY PRTDDLNGYQ 190 200 210 220 230 240 QEGFGPMDRT VTPQGRRAST ARGYLDQARG RPNLTIRTHA LTDHIIFAGK RAVGVEWLEG 250 260 270 280 290 300 ESTIPSKATA NKEVLLCAGA IASPQILQRS GVGNPELLRQ FDIPVVHDLP GVGENLQDHL 310 320 330 340 350 360 EMYLQYECKE PVSLYPALQW WNQPKIGAEW LFGGTGIGAS NQFEAGGFIR SRAEFAWPNI 370 380 390 400 410 420 QYHFLPVAIN YNGSNAVKEH GFQCHVGSMR SPSRGHVRLK SRDPHAHPAI LFNYMSHEQD 430 440 450 460 470 480 WQEFRDAIRI TREIMNQPAL DKYRGREISP GIECQSDAEL DEFVRNHAET AFHPCGTCKM 490 500 510 520 530 540 GYDEMAVVDG EGRVHGLEGL RVVDASIMPQ IITGNLNATT IMIGEKMADA IRGRQPLPRS 550 TATYYVAGDA PVRR

References

[1]	McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000647 Genomic DNA. Translation: ABR76034.1.
RefSeq	YP_001334264.1.
3D structure databases
SMR	A6T613. Positions 2-531.
ModBase	Search...
Protein-protein interaction databases
STRING	A6T613.
Genome annotation databases
GeneID	5342671.
GenomeReviews	Gene locus KPN78578_05730 in contig CP000647_GR.
KEGG	kpn:KPN_00584.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2303.
HOGENOM	HBG734713.
OMA	RTVTPHG.
Family and domain databases
HAMAP	MF_00750. Choline_dehydrogen. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. betA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETA_KLEP7

Accession

Primary (citable) accession number: A6T613

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 21, 2007
Last modified:	February 9, 2010
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)