A6T5L2 (A6T5L2_KLEP7) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Beta-galactosidase PIRNR PIRNR001084
Short name=Beta-gal PIRNR PIRNR001084
EC=3.2.1.23 PIRNR PIRNR001084

Gene names

Ordered Locus Names:	KPN78578_04220
ORF Names:	KPN_00431 EMBL ABR75883.1

Organism

Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [Complete proteome] [HAMAP]

Taxonomic identifier

272620 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	685 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. PIRNR PIRNR001084
Sequence similarities	Belongs to the glycosyl hydrolase 42 family. PIRNR PIRNR001084

Ontologies

Keywords
Ligand	Metal-binding PIRSR PIRSR001084-3 Zinc PIRSR PIRSR001084-3
Molecular function	Glycosidase PIRNR PIRNR001084 Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	beta-galactosidase complex Inferred from electronic annotation. Source: InterPro
Molecular function	beta-galactosidase activity Inferred from electronic annotation. Source: EC cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	157	1	Proton donor By similarity PIRSR PIRSR001084-1
	Active site	314	1	Nucleophile By similarity PIRSR PIRSR001084-1
	Metal binding	122	1	Zinc By similarity PIRSR PIRSR001084-3
	Metal binding	162	1	Zinc By similarity PIRSR PIRSR001084-3
	Metal binding	164	1	Zinc By similarity PIRSR PIRSR001084-3
	Metal binding	167	1	Zinc By similarity PIRSR PIRSR001084-3
	Binding site	118	1	Substrate By similarity PIRSR PIRSR001084-2
	Binding site	156	1	Substrate By similarity PIRSR PIRSR001084-2
	Binding site	322	1	Substrate By similarity PIRSR PIRSR001084-2

Sequences

	Sequence		Length	Mass (Da)
	A6T5L2 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: EF6C09B15BA92470	FASTA	685	77,585
	10 20 30 40 50 60 MNKFAPLHPK VSTLLHGADY NPEQWENDPD IIDKDIAMMQ QAKCNVMSVG IFSWAKLEPR 70 80 90 100 110 120 EGVFNFAWLD IILDKLYAAG IHVFLATPSG ARPAWMSQRY PQVLRVGRDR VPALHGGRHN 130 140 150 160 170 180 HCMSSPVYRE KTLQINTLLA ERYSSHPAVL GWHISNEYGG ECHCDLCQNR FRDWLKARYQ 190 200 210 220 230 240 TLENLNQAWW STFWSHTYTD WSQIESPAPQ GEMSIHGLNL DWHRFNTAQV TDFCRHEIAP 250 260 270 280 290 300 LKAANASLPV TTNFMEYFYD YDYWRLAEAL DFISWDSYPM WHRDKDETAL ACYTAMYHDM 310 320 330 340 350 360 MRSLKGGKPF VLMESTPGAT NWQPTSKLKK PGMHILSSLQ AVAHGADSVQ YFQWRKSRGS 370 380 390 400 410 420 VEKFHGAVVD HVGHIDTRIG REVCQLGVIL SKLPEVRGCR TEAKVAIIFD QQNRWALDDA 430 440 450 460 470 480 QGPRNLGMEY EKTVNEHYRP FWEQGIAVDV IDADVDLTPY QLVIAPMLYM VRDGFAGRAE 490 500 510 520 530 540 AFVANGGHLV TTYWTGIVNE SDLCYLGGFP GPLRNLLGIW AEEIDCLNDG EFNLVQGLAG 550 560 570 580 590 600 NQCGLQGPYQ VRHLCELIHI ESAQALATYR DDFYAGRPAV TVNAFGKGKA WHVASRNDLA 610 620 630 640 650 660 FQRDFFTALS KELALPRAIA TELPPGVVAT ARTDGDNAFI FLQNYSAQNH TLTLPQGYWD 670 680 CLTDAAVSAP LTLSAWDCRI LRRHA

References

[1]	McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700721 / MGH 78578.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000647 Genomic DNA. Translation: ABR75883.1.
RefSeq	YP_001334113.1. NC_009648.1.
3D structure databases
ProteinModelPortal	A6T5L2.
ModBase	Search...
Protein-protein interaction databases
STRING	A6T5L2.
Protein family/group databases
CAZy	GH42. Glycoside Hydrolase Family 42.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5340614.
GenomeReviews	Gene locus KPN78578_04220 in contig CP000647_GR.
KEGG	kpn:KPN_00431.
PATRIC	20455063. VBIKlePne13394_0438.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1874.
HOGENOM	HBG476453.
OMA	HGSDTVQ.
ProtClustDB	CLSK888649.
Family and domain databases
InterPro	IPR013739. Beta_galactosidase_C. IPR013738. Beta_galactosidase_Trimer. IPR013780. Glyco_hydro_13_b. IPR003476. Glyco_hydro_42. IPR013529. Glyco_hydro_42_N. IPR013781. Glyco_hydro_subgr_catalytic. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Gene3D	G3DSA:2.60.40.1180. Glyco_hydro_13_b. 1 hit. G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
KO	K12308.
Pfam	PF02449. Glyco_hydro_42. 1 hit. PF08533. Glyco_hydro_42C. 1 hit. PF08532. Glyco_hydro_42M. 1 hit. [Graphical view]
PIRSF	PIRSF001084. B-galactosidase. 1 hit.
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A6T5L2_KLEP7

Accession

Primary (citable) accession number: A6T5L2

Entry history

Integrated into UniProtKB/TrEMBL:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)