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Protein

Acyl carrier protein phosphodiesterase

Gene

acpH

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.UniRule annotation

Catalytic activityi

Holo-[acyl-carrier-protein] + H2O = 4'-phosphopantetheine + apo-[acyl-carrier-protein].UniRule annotation

GO - Molecular functioni

  1. [acyl-carrier-protein] phosphodiesterase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-355-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl carrier protein phosphodiesteraseUniRule annotation (EC:3.1.4.14UniRule annotation)
Short name:
ACP phosphodiesteraseUniRule annotation
Gene namesi
Name:acpHUniRule annotation
Ordered Locus Names:KPN78578_03460
ORF Names:KPN_00355
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000000265: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Acyl carrier protein phosphodiesterasePRO_1000070626Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272620.KPN_00355.

Family & Domainsi

Sequence similaritiesi

Belongs to the AcpH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3124.
HOGENOMiHOG000275880.
KOiK08682.
OMAiHFLAKNW.
OrthoDBiEOG6K6V7H.

Family and domain databases

HAMAPiMF_01950. AcpH.
InterProiIPR007431. ACP_phosphodiesterase.
IPR023491. ACP_phosphodiesterase_gpbac.
[Graphical view]
PfamiPF04336. DUF479. 1 hit.
[Graphical view]
PIRSFiPIRSF011489. DUF479. 1 hit.

Sequencei

Sequence statusi: Complete.

A6T5D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFLAHLHLA HLADSSLPGN LMADFVRGNP QGDYPAEIID GIYMHRRIDV
60 70 80 90 100
MTDNLAEVKE AREWFRPQTR RVAPITLDVM WDHFLSQHWA QLSPDLPLDE
110 120 130 140 150
FVRYAERQIV PILPDSPPRF VNLNQYLWSE RWLERYREMD FIQRVLNGMA
160 170 180 190
SRRPRLEALR DSWQDLDTHY DRLETQFWRF YPQMMRLAEN KQL
Length:193
Mass (Da):23,252
Last modified:August 21, 2007 - v1
Checksum:i4675929B569BD221
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR75807.1.
RefSeqiYP_001334037.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR75807; ABR75807; KPN_00355.
GeneIDi5341407.
KEGGikpn:KPN_00355.
PATRICi20454903. VBIKlePne13394_0358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA. Translation: ABR75807.1.
RefSeqiYP_001334037.1. NC_009648.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272620.KPN_00355.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR75807; ABR75807; KPN_00355.
GeneIDi5341407.
KEGGikpn:KPN_00355.
PATRICi20454903. VBIKlePne13394_0358.

Phylogenomic databases

eggNOGiCOG3124.
HOGENOMiHOG000275880.
KOiK08682.
OMAiHFLAKNW.
OrthoDBiEOG6K6V7H.

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-355-MONOMER.

Family and domain databases

HAMAPiMF_01950. AcpH.
InterProiIPR007431. ACP_phosphodiesterase.
IPR023491. ACP_phosphodiesterase_gpbac.
[Graphical view]
PfamiPF04336. DUF479. 1 hit.
[Graphical view]
PIRSFiPIRSF011489. DUF479. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700721 / MGH 78578.

Entry informationi

Entry nameiACPH_KLEP7
AccessioniPrimary (citable) accession number: A6T5D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: February 4, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.