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A6T4K0 (ARAA_KLEP7) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
L-arabinose isomerase
EC=5.3.1.4
Gene names
Name:araA
Ordered Locus Names:KPN78578_00600
ORF Names:KPN_00061
OrganismKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [Complete proteome] [HAMAP]
Taxonomic identifier272620 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519

Catalytic activity

L-arabinose = L-ribulose. HAMAP MF_00519

Cofactor

Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519

Pathway

Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519

Subunit structure

Homohexamer By similarity. HAMAP MF_00519

Sequence similarities

Belongs to the arabinose isomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500L-arabinose isomerase HAMAP MF_00519
PRO_1000050907

Sites

Metal binding3061Manganese By similarity
Metal binding3331Manganese By similarity
Metal binding3501Manganese By similarity
Metal binding4501Manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
A6T4K0 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 12ECA2C4A4C42B9A

FASTA50055,826
        10         20         30         40         50         60 
MTIFDNYEVW FVIGSQHLYG PEALRQVTKH AEHVVNSLNA EAKLPCKLVL KPLGTTPDEI 

        70         80         90        100        110        120 
THICRDANYD DKCAGLVVWL HTFSPAKMWI NGLTILNKPL LQFHTQYNAA LPWDSIDMDF 

       130        140        150        160        170        180 
MNLNQTAHGG REFGFIGARM RQQHSVVTGH WQDKEAHQRI GGWMRQAVSK QDTRHLKVCR 

       190        200        210        220        230        240 
FGDNMREVAV TDGDKVAAQI KFGFSVNTWA VGDLVQVVNS ISDGDISALV DEYESSYRLT 

       250        260        270        280        290        300 
PAAQVHGDKR QNVLDAARIE LGMKRFLEQG GFHAFTTTFE DLHGLKQLPG LAVQRLMQQG 

       310        320        330        340        350        360 
YGFAGEGDWK TAALLRIMKV MSTGLQGGTS FMEDYTYHFD NGNDLVLGSH MLEVCPTIAT 

       370        380        390        400        410        420 
AEKPILDVQP LGIGGKADPA RLIFNTQTGP AIVASLIDLG DRFRLLVNTI ETVPTPHDLP 

       430        440        450        460        470        480 
KLPVANALWK AQPDLRTASE AWIIAGGAHH TVFSHALNLD DMRQFAELHD IELTVIDNDT 

       490        500 
RLPSFKDALR WNEVYYGSKR

« Hide

References

[1]The Klebsiella pneumonia Genome Sequencing Project
McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700721 / MGH 78578.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000647 Genomic DNA. Translation: ABR75521.1.
RefSeqYP_001333751.1. NC_009648.1.

3D structure databases

ProteinModelPortalA6T4K0.
SMRA6T4K0. Positions 1-497.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6T4K0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5342757.
GenomeReviewsGene locus KPN78578_00600 in contig CP000647_GR.
KEGGkpn:KPN_00061.
PATRIC20454297. VBIKlePne13394_0063.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2160.
HOGENOMHBG297198.
OMAEVCPTIA.
ProtClustDBPRK02929.

Family and domain databases

HAMAPMF_00519. Arabinose_Isome.
[Tree]
InterProIPR024664. Ara_Isoase_C.
IPR004216. Fuc/Ara_isomerase_C.
IPR009015. Fucose_isomerase_N/cen.
IPR003762. Lara_isomerase.
[Graphical view]
KOK01804.
PfamPF11762. Arabinose_Iso_C. 1 hit.
PF02610. Arabinose_Isome. 1 hit.
[Graphical view]
PIRSFPIRSF001478. L-ara_isomerase. 1 hit.
ProDomPD018364. Lara_isomerase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF50443. Fuc_isomerase_C. 1 hit.
SSF53743. Fuc_isomerase_N. 1 hit.
ProtoNetSearch...

Entry information

Entry nameARAA_KLEP7
AccessionPrimary (citable) accession number: A6T4K0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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