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A6T4I5

- APAH_KLEP7

UniProt

A6T4I5 - APAH_KLEP7

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Protein
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
Gene
apaH, KPN78578_00450, KPN_00046
Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity.UniRule annotation

Catalytic activityi

P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP.UniRule annotation

GO - Molecular functioni

  1. bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciKPNE272620:GKDC-46-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC:3.6.1.41)
    Alternative name(s):
    Ap4A hydrolase
    Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
    Diadenosine tetraphosphatase
    Gene namesi
    Name:apaH
    Ordered Locus Names:KPN78578_00450
    ORF Names:KPN_00046
    OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
    Taxonomic identifieri272620 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
    ProteomesiUP000000265: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 282282Bis(5'-nucleosyl)-tetraphosphatase, symmetricalUniRule annotation
    PRO_1000012067Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272620.KPN_00046.

    Structurei

    3D structure databases

    ProteinModelPortaliA6T4I5.
    SMRiA6T4I5. Positions 2-268.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Ap4A hydrolase family.

    Phylogenomic databases

    eggNOGiCOG0639.
    HOGENOMiHOG000251871.
    KOiK01525.
    OMAiINAFTRM.
    OrthoDBiEOG66B3WP.

    Family and domain databases

    Gene3Di3.60.21.10. 2 hits.
    HAMAPiMF_00199. ApaH.
    InterProiIPR004617. ApaH.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
    SUPFAMiSSF56300. SSF56300. 1 hit.
    TIGRFAMsiTIGR00668. apaH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6T4I5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTYLIGDVH GCYDELIALL AQVEFDPRRD TLWLTGDLVA RGPGSLEVLR    50
    YVKSLGDSVR LVLGNHDLHL LAVFAGISRN KPKDRLKPLL EAPDADELLN 100
    WLRRQPLLQV DEEKKLVMAH AGITPQWDLE TAQQCARDVE AVLSSDSYPF 150
    FLDAMYGDMP NHWSNELSGL ARLRFISNAF TRMRYCFPNG QLDMYSKEAP 200
    EDAPAPLKPW FAIPGPVSNA YSIAFGHWAS LEGRGTPEGI YALDTGCCWG 250
    GELTCLRWED KQYFTQPSNR QKSLDEGEAV AS 282
    Length:282
    Mass (Da):31,608
    Last modified:August 21, 2007 - v1
    Checksum:i6338617FE9FC7C21
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000647 Genomic DNA. Translation: ABR75506.1.
    RefSeqiYP_001333736.1. NC_009648.1.

    Genome annotation databases

    EnsemblBacteriaiABR75506; ABR75506; KPN_00046.
    GeneIDi5342351.
    KEGGikpn:KPN_00046.
    PATRICi20454267. VBIKlePne13394_0048.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000647 Genomic DNA. Translation: ABR75506.1 .
    RefSeqi YP_001333736.1. NC_009648.1.

    3D structure databases

    ProteinModelPortali A6T4I5.
    SMRi A6T4I5. Positions 2-268.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 272620.KPN_00046.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR75506 ; ABR75506 ; KPN_00046 .
    GeneIDi 5342351.
    KEGGi kpn:KPN_00046.
    PATRICi 20454267. VBIKlePne13394_0048.

    Phylogenomic databases

    eggNOGi COG0639.
    HOGENOMi HOG000251871.
    KOi K01525.
    OMAi INAFTRM.
    OrthoDBi EOG66B3WP.

    Enzyme and pathway databases

    BioCyci KPNE272620:GKDC-46-MONOMER.

    Family and domain databases

    Gene3Di 3.60.21.10. 2 hits.
    HAMAPi MF_00199. ApaH.
    InterProi IPR004617. ApaH.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000903. B5n-ttraPtase_sm. 1 hit.
    SUPFAMi SSF56300. SSF56300. 1 hit.
    TIGRFAMsi TIGR00668. apaH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700721 / MGH 78578.

    Entry informationi

    Entry nameiAPAH_KLEP7
    AccessioniPrimary (citable) accession number: A6T4I5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 21, 2007
    Last modified: June 11, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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