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A6T4I5

- APAH_KLEP7

UniProt

A6T4I5 - APAH_KLEP7

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Protein

Bis(5'-nucleosyl)-tetraphosphatase, symmetrical

Gene
apaH, KPN78578_00450, KPN_00046
Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity.UniRule annotation

Catalytic activityi

P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP.UniRule annotation

GO - Molecular functioni

  1. bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciKPNE272620:GKDC-46-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC:3.6.1.41)
Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase
Gene namesi
Name:apaH
Ordered Locus Names:KPN78578_00450
ORF Names:KPN_00046
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000000265: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Bis(5'-nucleosyl)-tetraphosphatase, symmetricalUniRule annotationPRO_1000012067Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272620.KPN_00046.

Structurei

3D structure databases

ProteinModelPortaliA6T4I5.
SMRiA6T4I5. Positions 2-268.

Family & Domainsi

Sequence similaritiesi

Belongs to the Ap4A hydrolase family.

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000251871.
KOiK01525.
OMAiINAFTRM.
OrthoDBiEOG66B3WP.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.

Sequencei

Sequence statusi: Complete.

A6T4I5-1 [UniParc]FASTAAdd to Basket

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MSTYLIGDVH GCYDELIALL AQVEFDPRRD TLWLTGDLVA RGPGSLEVLR    50
YVKSLGDSVR LVLGNHDLHL LAVFAGISRN KPKDRLKPLL EAPDADELLN 100
WLRRQPLLQV DEEKKLVMAH AGITPQWDLE TAQQCARDVE AVLSSDSYPF 150
FLDAMYGDMP NHWSNELSGL ARLRFISNAF TRMRYCFPNG QLDMYSKEAP 200
EDAPAPLKPW FAIPGPVSNA YSIAFGHWAS LEGRGTPEGI YALDTGCCWG 250
GELTCLRWED KQYFTQPSNR QKSLDEGEAV AS 282
Length:282
Mass (Da):31,608
Last modified:August 21, 2007 - v1
Checksum:i6338617FE9FC7C21
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR75506.1.
RefSeqiYP_001333736.1. NC_009648.1.

Genome annotation databases

EnsemblBacteriaiABR75506; ABR75506; KPN_00046.
GeneIDi5342351.
KEGGikpn:KPN_00046.
PATRICi20454267. VBIKlePne13394_0048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000647 Genomic DNA. Translation: ABR75506.1 .
RefSeqi YP_001333736.1. NC_009648.1.

3D structure databases

ProteinModelPortali A6T4I5.
SMRi A6T4I5. Positions 2-268.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272620.KPN_00046.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR75506 ; ABR75506 ; KPN_00046 .
GeneIDi 5342351.
KEGGi kpn:KPN_00046.
PATRICi 20454267. VBIKlePne13394_0048.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000251871.
KOi K01525.
OMAi INAFTRM.
OrthoDBi EOG66B3WP.

Enzyme and pathway databases

BioCyci KPNE272620:GKDC-46-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 2 hits.
HAMAPi MF_00199. ApaH.
InterProi IPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PIRSFi PIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMi SSF56300. SSF56300. 1 hit.
TIGRFAMsi TIGR00668. apaH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700721 / MGH 78578.

Entry informationi

Entry nameiAPAH_KLEP7
AccessioniPrimary (citable) accession number: A6T4I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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