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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:mma_3018
OrganismiJanthinobacterium sp. (strain Marseille) (Minibacterium massiliensis)
Taxonomic identifieri375286 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeJanthinobacterium
Proteomesi
  • UP000006388 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalUniRule annotationAdd BLAST21
Transmembranei70 – 90HelicalUniRule annotationAdd BLAST21
Transmembranei97 – 117HelicalUniRule annotationAdd BLAST21
Transmembranei134 – 154HelicalUniRule annotationAdd BLAST21
Transmembranei189 – 209HelicalUniRule annotationAdd BLAST21
Transmembranei222 – 242HelicalUniRule annotationAdd BLAST21
Transmembranei259 – 279HelicalUniRule annotationAdd BLAST21
Transmembranei286 – 306HelicalUniRule annotationAdd BLAST21
Transmembranei311 – 331HelicalUniRule annotationAdd BLAST21
Transmembranei366 – 386HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000029921 – 389Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST389

Interactioni

Protein-protein interaction databases

STRINGi375286.mma_3018.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A6T2G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLWLAQYFQ DELGPLRVFN FITFRAVFAT LTALVIGLVT GPAVIRMLTR
60 70 80 90 100
LKVGQAVRTD GPQTHLIKSG TPTMGGVLIL VSIGISTLLW TDLSNRFIWV
110 120 130 140 150
VLIVTLGFGA VGWVDDYRKV VYKDPKGMAS REKYMWQSII GLFAAIYLAF
160 170 180 190 200
SVSAPSNSQF LDLFIAWVQS GFSMDLPPKA DLIVPFFKTI SYPLGVWGFI
210 220 230 240 250
ALTYFVIVGT SNAVNLTDGL DGLAIMPTVM VGTALGLFAY LTGSANYSKY
260 270 280 290 300
LFIPHIPGAG ELIIFCGAMA GAGLAFLWFN AHPAQVFMGD VGALALGGAL
310 320 330 340 350
GTIAVIVRQE VVLFIMGGIF VVETLSVMLQ VAYFKYTKMR TGIGKRILLM
360 370 380
APLHHHFEQK GWKETQVVVR FWIITMMLVL FGLSTLKLR
Length:389
Mass (Da):42,701
Last modified:August 21, 2007 - v1
Checksum:iD3AAB68959690A35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000269 Genomic DNA. Translation: ABR88400.1.
RefSeqiWP_012080867.1. NC_009659.1.

Genome annotation databases

EnsemblBacteriaiABR88400; ABR88400; mma_3018.
KEGGimms:mma_3018.

Similar proteinsi

Entry informationi

Entry nameiMRAY_JANMA
AccessioniPrimary (citable) accession number: A6T2G1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: June 7, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families