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A6T2F6 (DDL_JANMA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:mma_3013
OrganismJanthinobacterium sp. (strain Marseille) (Minibacterium massiliensis) [Complete proteome] [HAMAP]
Taxonomic identifier375286 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeJanthinobacterium

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_1000057323

Regions

Domain104 – 308205ATP-grasp
Nucleotide binding134 – 18956ATP By similarity

Sites

Metal binding2611Magnesium or manganese 1 By similarity
Metal binding2751Magnesium or manganese 1 By similarity
Metal binding2751Magnesium or manganese 2 By similarity
Metal binding2771Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
A6T2F6 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: F19AB0811DDE7B8A

FASTA32034,332
        10         20         30         40         50         60 
MKKEFGKVGV LFGGRSAERE VSLMSGKGVL AALLSKGIDA HPFDPAERSL AELAAEKFDR 

        70         80         90        100        110        120 
VFIALHGRFG EDGSLQGALE QLGIPYTGPG VMASAIAMDK VITKRVCLSH GVPTPKFTAL 

       130        140        150        160        170        180 
EVEATTAEQL QAIAAEFGMP LMLKAPHEGS TIGIAKVETA EGMQAGFDLC AKYDDVVLVE 

       190        200        210        220        230        240 
QFVKGRELTV PVLGSGRNAR ALPIVEIIAP QGNYDYEHKY FSDDTQYLCP APFDAAFTKR 

       250        260        270        280        290        300 
VQALAVSAFN AVGCTGWARV DFLVRESDNE PFLLEINTSP GMTGHSLVPM SAKVAGTAYE 

       310        320 
DLCVEILRMA KLGLKPVQHK 

« Hide

References

[1]"Genome analysis of Minibacterium massiliensis highlights the convergent evolution of water-living bacteria."
Audic S., Robert C., Campagna B., Parinello H., Claverie J.-M., Raoult D., Drancourt M.
PLoS Genet. 3:1454-1463(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Marseille.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000269 Genomic DNA. Translation: ABR89041.1.
RefSeqYP_001354703.1. NC_009659.1.

3D structure databases

ProteinModelPortalA6T2F6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING375286.mma_3013.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR89041; ABR89041; mma_3013.
GeneID5352687.
KEGGmms:mma_3013.
PATRIC22158553. VBIJanSp106498_3039.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMADTQYRIP.
OrthoDBEOG6ND0KB.
ProtClustDBPRK01372.

Enzyme and pathway databases

BioCycJSP375286:GJ8U-3058-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_JANMA
AccessionPrimary (citable) accession number: A6T2F6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways