A6T2A5 (AROE_JANMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	mma_2962

Organism

Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis) [Complete proteome] [HAMAP]

Taxonomic identifier

375286 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Oxalobacteraceae › Janthinobacterium

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000325127
Regions
	Nucleotide binding	130 – 134	5	NADP By similarity
Sites
	Active site	69	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	A6T2A5 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 5AB98481D2E7BDBD	FASTA	273	29,390
	10 20 30 40 50 60 MSTRTDHYAV IGNPIAHSKS PDIHARFAAQ TQQDLKYDRL LAPLDGFLAS VQEFIRNDGK 70 80 90 100 110 120 GLNVTVPFKL EAYAMASRLS ERARAAGAVN TLKFENGEML GDNTDGVGLV TDIVRNAGVA 130 140 150 160 170 180 VAGKTVLLLG AGGAARGVIL PLLHEKPARL VIANRTHSKA LDLAERFAPQ PTLEVSDFGA 190 200 210 220 230 240 LDDAFDIVIN ATAASLASEV PPISPRVFAK RTLAYDMMYG AAPTPFMQFA AEHGATVRDG 250 260 270 LGMLVEQAAE SFYVWRNVRP ETAAVFKELR DKL

References

[1]

"Genome analysis of Minibacterium massiliensis highlights the convergent evolution of water-living bacteria." Audic S., Robert C., Campagna B., Parinello H., Claverie J.-M., Raoult D., Drancourt M. PLoS Genet. 3:1454-1463(2007) [PubMed: 17722982] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Marseille.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000269 Genomic DNA. Translation: ABR88541.1.
RefSeq	YP_001354652.1. NC_009659.1.
3D structure databases
ProteinModelPortal	A6T2A5.
ModBase	Search...
Protein-protein interaction databases
STRING	A6T2A5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5351501.
GenomeReviews	Gene locus mma_2962 in contig CP000269_GR.
KEGG	mms:mma_2962.
PATRIC	22158445. VBIJanSp106498_2985.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	VVFGNPI.
ProtClustDB	CLSK967450.
Enzyme and pathway databases
BioCyc	JSP375286:MMA_2962-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_JANMA

Accession

Primary (citable) accession number: A6T2A5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	August 21, 2007
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program