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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei641ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciJSP375286:G1G65-3035-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:mma_2896
OrganismiJanthinobacterium sp. (strain Marseille) (Minibacterium massiliensis)
Taxonomic identifieri375286 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeJanthinobacterium
Proteomesi
  • UP000006388 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000093541 – 881Leucine--tRNA ligaseAdd BLAST881

Proteomic databases

PRIDEiA6T239

Interactioni

Protein-protein interaction databases

STRINGi375286.mma_2896

Structurei

3D structure databases

ProteinModelPortaliA6T239
SMRiA6T239
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi48 – 58"HIGH" regionAdd BLAST11
Motifi638 – 642"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A6T239-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDKYSPAEV EKSAHDHWQA IDAYKAVENA KDKNGKDKKK FYACSMLPYP
60 70 80 90 100
SGKLHMGHVR NYTINDVMYR YLRMNGYNVL MPMGWDAFGM PAENAAMANN
110 120 130 140 150
VPPAQWTYAN IDYMKTQMAS MGLAIDWSRE MTACRPEYYK WNQWMFLKML
160 170 180 190 200
EKGIIYKKTG TVNWDPIDQT VLANEQVIDG RGWRSGALIE KREIPMYYAR
210 220 230 240 250
ITDYAEELLD HVDNKLPGWP ERVRIMQSNW IGKSTGVRFA FTHDIAEEGK
260 270 280 290 300
LINDGKLWVF TTRADTIKGV TFCAVAPEHA LATFAAKSNP ELTDFIAECK
310 320 330 340 350
LGSVIEADMA TMEKKGMPTG LFVKHPLTGQ LVEVWVGNYV LITYGDGAVM
360 370 380 390 400
GVPAHDERDF AFAQKYVLPI HPVIDVPGKT FSDVAWHEWY GDKENGRCIN
410 420 430 440 450
SGKYDGLNYQ QAVDAIAADL AELGLGEKKI TYRLRDWGIS RQRYWGTPIP
460 470 480 490 500
IIHCKDCGDV PVPEKDLPVV LPEDCVPDGS GNPLNKHEKF LHVDCPQCGK
510 520 530 540 550
PARRETDTMD TFVDSSWYYM RYCSPNSSDA MVDSRNDYWM PMDQYIGGIE
560 570 580 590 600
HAVLHLLYAR FWTKVMRDFG LVKFDEPFTN LLTQGMVLNE TYFREDASGK
610 620 630 640 650
KTWFNPADVQ LQLDDKGRPV SAVLSSDGKA VEIGGTEKMS KSKNNGIDPQ
660 670 680 690 700
AQIDQYGADT ARLFTMFASP PEQTLEWSGA GVEGANRFLR RVWAYGYNQA
710 720 730 740 750
ARVANASAFD FATLPEAHKA LRRETHKILQ QADNDYKRIQ YNTVVSASMK
760 770 780 790 800
MLNTLEAAKL DDSPASNAVI SEGLSIFLRI LNPVAPHITH ALWQELGFAK
810 820 830 840 850
DHGDILDAPW PQVDPAALEQ AEIEMMIQVN GKLRGSIIVA KDADKASIEA
860 870 880
AALANESVQK FIEGTPKKII VVPGKLVNIV A
Length:881
Mass (Da):98,999
Last modified:August 21, 2007 - v1
Checksum:i0B6DE8EE81B226D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000269 Genomic DNA Translation: ABR89205.1
RefSeqiWP_012080745.1, NC_009659.1

Genome annotation databases

EnsemblBacteriaiABR89205; ABR89205; mma_2896
KEGGimms:mma_2896

Similar proteinsi

Entry informationi

Entry nameiSYL_JANMA
AccessioniPrimary (citable) accession number: A6T239
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
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