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A6T239

- SYL_JANMA

UniProt

A6T239 - SYL_JANMA

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei641 – 6411ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciJSP375286:GJ8U-2941-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:mma_2896
    OrganismiJanthinobacterium sp. (strain Marseille) (Minibacterium massiliensis)
    Taxonomic identifieri375286 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeJanthinobacterium
    ProteomesiUP000006388: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 881881Leucine--tRNA ligasePRO_1000009354Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi375286.mma_2896.

    Structurei

    3D structure databases

    ProteinModelPortaliA6T239.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi48 – 5811"HIGH" regionAdd
    BLAST
    Motifi638 – 6425"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 2 hits.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6T239-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQDKYSPAEV EKSAHDHWQA IDAYKAVENA KDKNGKDKKK FYACSMLPYP    50
    SGKLHMGHVR NYTINDVMYR YLRMNGYNVL MPMGWDAFGM PAENAAMANN 100
    VPPAQWTYAN IDYMKTQMAS MGLAIDWSRE MTACRPEYYK WNQWMFLKML 150
    EKGIIYKKTG TVNWDPIDQT VLANEQVIDG RGWRSGALIE KREIPMYYAR 200
    ITDYAEELLD HVDNKLPGWP ERVRIMQSNW IGKSTGVRFA FTHDIAEEGK 250
    LINDGKLWVF TTRADTIKGV TFCAVAPEHA LATFAAKSNP ELTDFIAECK 300
    LGSVIEADMA TMEKKGMPTG LFVKHPLTGQ LVEVWVGNYV LITYGDGAVM 350
    GVPAHDERDF AFAQKYVLPI HPVIDVPGKT FSDVAWHEWY GDKENGRCIN 400
    SGKYDGLNYQ QAVDAIAADL AELGLGEKKI TYRLRDWGIS RQRYWGTPIP 450
    IIHCKDCGDV PVPEKDLPVV LPEDCVPDGS GNPLNKHEKF LHVDCPQCGK 500
    PARRETDTMD TFVDSSWYYM RYCSPNSSDA MVDSRNDYWM PMDQYIGGIE 550
    HAVLHLLYAR FWTKVMRDFG LVKFDEPFTN LLTQGMVLNE TYFREDASGK 600
    KTWFNPADVQ LQLDDKGRPV SAVLSSDGKA VEIGGTEKMS KSKNNGIDPQ 650
    AQIDQYGADT ARLFTMFASP PEQTLEWSGA GVEGANRFLR RVWAYGYNQA 700
    ARVANASAFD FATLPEAHKA LRRETHKILQ QADNDYKRIQ YNTVVSASMK 750
    MLNTLEAAKL DDSPASNAVI SEGLSIFLRI LNPVAPHITH ALWQELGFAK 800
    DHGDILDAPW PQVDPAALEQ AEIEMMIQVN GKLRGSIIVA KDADKASIEA 850
    AALANESVQK FIEGTPKKII VVPGKLVNIV A 881
    Length:881
    Mass (Da):98,999
    Last modified:August 21, 2007 - v1
    Checksum:i0B6DE8EE81B226D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000269 Genomic DNA. Translation: ABR89205.1.
    RefSeqiWP_012080745.1. NC_009659.1.
    YP_001354586.1. NC_009659.1.

    Genome annotation databases

    EnsemblBacteriaiABR89205; ABR89205; mma_2896.
    GeneIDi5352419.
    KEGGimms:mma_2896.
    PATRICi22158311. VBIJanSp106498_2918.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000269 Genomic DNA. Translation: ABR89205.1 .
    RefSeqi WP_012080745.1. NC_009659.1.
    YP_001354586.1. NC_009659.1.

    3D structure databases

    ProteinModelPortali A6T239.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 375286.mma_2896.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR89205 ; ABR89205 ; mma_2896 .
    GeneIDi 5352419.
    KEGGi mms:mma_2896.
    PATRICi 22158311. VBIJanSp106498_2918.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci JSP375286:GJ8U-2941-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 2 hits.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome analysis of Minibacterium massiliensis highlights the convergent evolution of water-living bacteria."
      Audic S., Robert C., Campagna B., Parinello H., Claverie J.-M., Raoult D., Drancourt M.
      PLoS Genet. 3:1454-1463(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Marseille.

    Entry informationi

    Entry nameiSYL_JANMA
    AccessioniPrimary (citable) accession number: A6T239
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3