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A6T239

- SYL_JANMA

UniProt

A6T239 - SYL_JANMA

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei641 – 6411ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciJSP375286:GJ8U-2941-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:mma_2896
OrganismiJanthinobacterium sp. (strain Marseille) (Minibacterium massiliensis)
Taxonomic identifieri375286 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeJanthinobacterium
ProteomesiUP000006388: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 881881Leucine--tRNA ligasePRO_1000009354Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi375286.mma_2896.

Structurei

3D structure databases

ProteinModelPortaliA6T239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 5811"HIGH" regionAdd
BLAST
Motifi638 – 6425"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6T239-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQDKYSPAEV EKSAHDHWQA IDAYKAVENA KDKNGKDKKK FYACSMLPYP
60 70 80 90 100
SGKLHMGHVR NYTINDVMYR YLRMNGYNVL MPMGWDAFGM PAENAAMANN
110 120 130 140 150
VPPAQWTYAN IDYMKTQMAS MGLAIDWSRE MTACRPEYYK WNQWMFLKML
160 170 180 190 200
EKGIIYKKTG TVNWDPIDQT VLANEQVIDG RGWRSGALIE KREIPMYYAR
210 220 230 240 250
ITDYAEELLD HVDNKLPGWP ERVRIMQSNW IGKSTGVRFA FTHDIAEEGK
260 270 280 290 300
LINDGKLWVF TTRADTIKGV TFCAVAPEHA LATFAAKSNP ELTDFIAECK
310 320 330 340 350
LGSVIEADMA TMEKKGMPTG LFVKHPLTGQ LVEVWVGNYV LITYGDGAVM
360 370 380 390 400
GVPAHDERDF AFAQKYVLPI HPVIDVPGKT FSDVAWHEWY GDKENGRCIN
410 420 430 440 450
SGKYDGLNYQ QAVDAIAADL AELGLGEKKI TYRLRDWGIS RQRYWGTPIP
460 470 480 490 500
IIHCKDCGDV PVPEKDLPVV LPEDCVPDGS GNPLNKHEKF LHVDCPQCGK
510 520 530 540 550
PARRETDTMD TFVDSSWYYM RYCSPNSSDA MVDSRNDYWM PMDQYIGGIE
560 570 580 590 600
HAVLHLLYAR FWTKVMRDFG LVKFDEPFTN LLTQGMVLNE TYFREDASGK
610 620 630 640 650
KTWFNPADVQ LQLDDKGRPV SAVLSSDGKA VEIGGTEKMS KSKNNGIDPQ
660 670 680 690 700
AQIDQYGADT ARLFTMFASP PEQTLEWSGA GVEGANRFLR RVWAYGYNQA
710 720 730 740 750
ARVANASAFD FATLPEAHKA LRRETHKILQ QADNDYKRIQ YNTVVSASMK
760 770 780 790 800
MLNTLEAAKL DDSPASNAVI SEGLSIFLRI LNPVAPHITH ALWQELGFAK
810 820 830 840 850
DHGDILDAPW PQVDPAALEQ AEIEMMIQVN GKLRGSIIVA KDADKASIEA
860 870 880
AALANESVQK FIEGTPKKII VVPGKLVNIV A
Length:881
Mass (Da):98,999
Last modified:August 21, 2007 - v1
Checksum:i0B6DE8EE81B226D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000269 Genomic DNA. Translation: ABR89205.1.
RefSeqiWP_012080745.1. NC_009659.1.
YP_001354586.1. NC_009659.1.

Genome annotation databases

EnsemblBacteriaiABR89205; ABR89205; mma_2896.
GeneIDi5352419.
KEGGimms:mma_2896.
PATRICi22158311. VBIJanSp106498_2918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000269 Genomic DNA. Translation: ABR89205.1 .
RefSeqi WP_012080745.1. NC_009659.1.
YP_001354586.1. NC_009659.1.

3D structure databases

ProteinModelPortali A6T239.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 375286.mma_2896.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR89205 ; ABR89205 ; mma_2896 .
GeneIDi 5352419.
KEGGi mms:mma_2896.
PATRICi 22158311. VBIJanSp106498_2918.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci JSP375286:GJ8U-2941-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome analysis of Minibacterium massiliensis highlights the convergent evolution of water-living bacteria."
    Audic S., Robert C., Campagna B., Parinello H., Claverie J.-M., Raoult D., Drancourt M.
    PLoS Genet. 3:1454-1463(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Marseille.

Entry informationi

Entry nameiSYL_JANMA
AccessioniPrimary (citable) accession number: A6T239
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3