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A6T239

- SYL_JANMA

UniProt

A6T239 - SYL_JANMA

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Protein

Leucine--tRNA ligase

Gene
leuS, mma_2896
Organism
Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei641 – 6411ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciJSP375286:GJ8U-2941-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:mma_2896
OrganismiJanthinobacterium sp. (strain Marseille) (Minibacterium massiliensis)
Taxonomic identifieri375286 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeJanthinobacterium
ProteomesiUP000006388: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 881881Leucine--tRNA ligaseUniRule annotationPRO_1000009354Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi375286.mma_2896.

Structurei

3D structure databases

ProteinModelPortaliA6T239.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 5811"HIGH" regionUniRule annotationAdd
BLAST
Motifi638 – 6425"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6T239-1 [UniParc]FASTAAdd to Basket

« Hide

MQDKYSPAEV EKSAHDHWQA IDAYKAVENA KDKNGKDKKK FYACSMLPYP    50
SGKLHMGHVR NYTINDVMYR YLRMNGYNVL MPMGWDAFGM PAENAAMANN 100
VPPAQWTYAN IDYMKTQMAS MGLAIDWSRE MTACRPEYYK WNQWMFLKML 150
EKGIIYKKTG TVNWDPIDQT VLANEQVIDG RGWRSGALIE KREIPMYYAR 200
ITDYAEELLD HVDNKLPGWP ERVRIMQSNW IGKSTGVRFA FTHDIAEEGK 250
LINDGKLWVF TTRADTIKGV TFCAVAPEHA LATFAAKSNP ELTDFIAECK 300
LGSVIEADMA TMEKKGMPTG LFVKHPLTGQ LVEVWVGNYV LITYGDGAVM 350
GVPAHDERDF AFAQKYVLPI HPVIDVPGKT FSDVAWHEWY GDKENGRCIN 400
SGKYDGLNYQ QAVDAIAADL AELGLGEKKI TYRLRDWGIS RQRYWGTPIP 450
IIHCKDCGDV PVPEKDLPVV LPEDCVPDGS GNPLNKHEKF LHVDCPQCGK 500
PARRETDTMD TFVDSSWYYM RYCSPNSSDA MVDSRNDYWM PMDQYIGGIE 550
HAVLHLLYAR FWTKVMRDFG LVKFDEPFTN LLTQGMVLNE TYFREDASGK 600
KTWFNPADVQ LQLDDKGRPV SAVLSSDGKA VEIGGTEKMS KSKNNGIDPQ 650
AQIDQYGADT ARLFTMFASP PEQTLEWSGA GVEGANRFLR RVWAYGYNQA 700
ARVANASAFD FATLPEAHKA LRRETHKILQ QADNDYKRIQ YNTVVSASMK 750
MLNTLEAAKL DDSPASNAVI SEGLSIFLRI LNPVAPHITH ALWQELGFAK 800
DHGDILDAPW PQVDPAALEQ AEIEMMIQVN GKLRGSIIVA KDADKASIEA 850
AALANESVQK FIEGTPKKII VVPGKLVNIV A 881
Length:881
Mass (Da):98,999
Last modified:August 21, 2007 - v1
Checksum:i0B6DE8EE81B226D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000269 Genomic DNA. Translation: ABR89205.1.
RefSeqiWP_012080745.1. NC_009659.1.
YP_001354586.1. NC_009659.1.

Genome annotation databases

EnsemblBacteriaiABR89205; ABR89205; mma_2896.
GeneIDi5352419.
KEGGimms:mma_2896.
PATRICi22158311. VBIJanSp106498_2918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000269 Genomic DNA. Translation: ABR89205.1 .
RefSeqi WP_012080745.1. NC_009659.1.
YP_001354586.1. NC_009659.1.

3D structure databases

ProteinModelPortali A6T239.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 375286.mma_2896.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR89205 ; ABR89205 ; mma_2896 .
GeneIDi 5352419.
KEGGi mms:mma_2896.
PATRICi 22158311. VBIJanSp106498_2918.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci JSP375286:GJ8U-2941-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome analysis of Minibacterium massiliensis highlights the convergent evolution of water-living bacteria."
    Audic S., Robert C., Campagna B., Parinello H., Claverie J.-M., Raoult D., Drancourt M.
    PLoS Genet. 3:1454-1463(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Marseille.

Entry informationi

Entry nameiSYL_JANMA
AccessioniPrimary (citable) accession number: A6T239
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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