A6T1G3 (AROA_JANMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	mma_2670

Organism

Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis) [Complete proteome] [HAMAP]

Taxonomic identifier

375286 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Oxalobacteraceae › Janthinobacterium

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 441	441	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_0000325353

Sequences

	Sequence		Length	Mass (Da)
	A6T1G3 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: F3530392F412B5E1	FASTA	441	48,053
	10 20 30 40 50 60 MKHYPHYLDL KPAMHAKGVV RLPGSKSISN RTLLLAALAQ GTTHIRDLLA SDDTHVMLMA 70 80 90 100 110 120 LQKLGVKWEQ IGESQDYIVH GVDGSFPVHQ ADLFMGNAGT AIRPLTAALA VTGGDYTLHG 130 140 150 160 170 180 VSRMHERPIG DLVDALNAIG THIEYTGEPG YPPLHIQRGR IHAHEMSVRG NVSSQFLTAL 190 200 210 220 230 240 LMAAPLMTRE QDVIINVIGD LISKPYIEIT LNLIQRFGVE VQRNGWQSFT IKAGQRYISP 250 260 270 280 290 300 GNIHVEGDAS SASYFLAAGA IAGGPVRVEG VGRDSIQGDV RFVEALEQMG ATVRMGDNWI 310 320 330 340 350 360 EAESNGVLRA IDADFNHIPD AAMTIAVAAL YADGPSILRN IGSWRVKETD RISAMATELR 370 380 390 400 410 420 KLGAIVEEGE DYLKVTPPAE ILSAAIDTYD DHRMAMCFSL ATLDGAARRG NKERINDPQC 430 440 VAKTFPEYFE AFAKVTEESL F

References

[1]

"Genome analysis of Minibacterium massiliensis highlights the convergent evolution of water-living bacteria." Audic S., Robert C., Campagna B., Parinello H., Claverie J.-M., Raoult D., Drancourt M. PLoS Genet. 3:1454-1463(2007) [PubMed: 17722982] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Marseille.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000269 Genomic DNA. Translation: ABR88781.1.
RefSeq	YP_001354360.1. NC_009659.1.
3D structure databases
ProteinModelPortal	A6T1G3.
ModBase	Search...
Protein-protein interaction databases
STRING	A6T1G3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5352774.
GenomeReviews	Gene locus mma_2670 in contig CP000269_GR.
KEGG	mms:mma_2670.
PATRIC	22157847. VBIJanSp106498_2686.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0128.
HOGENOM	HBG646626.
OMA	GADIEWG.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	JSP375286:MMA_2670-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_JANMA

Accession

Primary (citable) accession number: A6T1G3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	August 21, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program