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Protein

Catalase-peroxidase

Gene

katG

Organism
Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei88Transition state stabilizerUniRule annotation1
Active sitei92Proton acceptorUniRule annotation1
Metal bindingi256Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:mma_1554
OrganismiJanthinobacterium sp. (strain Marseille) (Minibacterium massiliensis)
Taxonomic identifieri375286 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeJanthinobacterium
Proteomesi
  • UP000006388 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003548131 – 725Catalase-peroxidaseAdd BLAST725

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki91 ↔ 215Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-241)UniRule annotation
Cross-linki215 ↔ 241Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-91)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA6SY97.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi375286.mma_1554.

Structurei

3D structure databases

ProteinModelPortaliA6SY97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6SY97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEAKCPFP HAANRSRSNQ DWWPNQLRVD VLNQHSNKSN PLGEKFNYAE
60 70 80 90 100
EFKKLDYKAL KADLVKLMTD SQDWWPADFG HYGPQFVRMA WHATGTYRTM
110 120 130 140 150
DGRGGGGRGQ QRFAPLNSWP DNVNIDKSRR LLWPIKQKYG QRISWADLLV
160 170 180 190 200
LTGNVALESM GFRTFGFAGG RADVWEPDTD VNWGAETTWL GTDKRFSGDR
210 220 230 240 250
ELDENLSATH MGLIYVNPEG PDGSGDYMAA AKDIRATFYR MAMDDEEIVA
260 270 280 290 300
LIAGGHTFGK AHGAAPESHK GAEPEGAPIE AQGLGWVSNF GDGYGKDTVS
310 320 330 340 350
SGLEVTWTKT PALWSNNFFE NLFKYEWEIT KSPAGAKQWV AKDAEDIIPD
360 370 380 390 400
AHIKGKFHKP TMLTTDLTLR FDPEFGKISK RFYEDPQAFA EAFARAWFKL
410 420 430 440 450
THRDMGPRSR YLGPEVPKEE LIWQDPIPEV DYKLVDAADV TALKAKLLTS
460 470 480 490 500
GLSVSELVGT AWASASTFRG SDKRGGANGA RIRLAPMKDW EVNQPEQLAK
510 520 530 540 550
VLKTLEGIQA DFNQSASGGK QVSLADLIVL AGSVGVEQAA KAAGVNVSVP
560 570 580 590 600
FAAGRNDARQ DQTDVESFAA LEPRTDGFRN YVGKKNGVPA EVALIDKAQL
610 620 630 640 650
LCLSVPELTV LISGLRAINI NVGGVKHGVL TRTPGVLNNE VLLNLLDMGT
660 670 680 690 700
QWKPVESDAN VFEGRDRKSG EVKWTATRAD LVFGSNSILR SVAEVYAESD
710 720
AKEKFVKDFV AAWVKVMNAD RFDLA
Length:725
Mass (Da):79,946
Last modified:August 21, 2007 - v1
Checksum:i8143CC753706B446
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000269 Genomic DNA. Translation: ABR88756.1.
RefSeqiWP_012079409.1. NC_009659.1.

Genome annotation databases

EnsemblBacteriaiABR88756; ABR88756; mma_1554.
KEGGimms:mma_1554.
PATRICi22155605. VBIJanSp106498_1572.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000269 Genomic DNA. Translation: ABR88756.1.
RefSeqiWP_012079409.1. NC_009659.1.

3D structure databases

ProteinModelPortaliA6SY97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi375286.mma_1554.

Proteomic databases

PRIDEiA6SY97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR88756; ABR88756; mma_1554.
KEGGimms:mma_1554.
PATRICi22155605. VBIJanSp106498_1572.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_JANMA
AccessioniPrimary (citable) accession number: A6SY97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: August 21, 2007
Last modified: November 2, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.