A6SXN8 (A6SXN8_JANMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
6,7-dimethyl-8-ribityllumazine synthase 1 HAMAP MF_00178
Short name=DMRL synthase 1 HAMAP MF_00178
Short name=Lumazine synthase 1 HAMAP MF_00178
EC=2.5.1.9 HAMAP MF_00178

Alternative name(s):
Riboflavin synthase beta chain 1 HAMAP MF_00178

Gene names

Name:	ribH1 HAMAP MF_00178 EMBL ABR88799.1
Ordered Locus Names:	mma_1345

Organism

Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis) [Complete proteome] [HAMAP]

Taxonomic identifier

375286 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Oxalobacteraceae › Janthinobacterium

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2-butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes the condensation of 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate yielding 6,7-dimethyl-8-lumazine By similarity. HAMAP MF_00178
Catalytic activity	2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine. HAMAP MF_00178
Pathway	Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2. HAMAP MF_00178
Sequence similarities	Belongs to the DMRL synthase family. HAMAP MF_00178

Ontologies

Keywords
Biological process	Riboflavin biosynthesis HAMAP MF_00178
Molecular function	Transferase HAMAP MF_00178 EMBL ABR88799.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	riboflavin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	riboflavin synthase complex Inferred from electronic annotation. Source: InterPro
Molecular function	riboflavin synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A6SXN8 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: B136071B8DEFB22C	FASTA	167	18,634
	10 20 30 40 50 60 MQHPIDIKTK SAVRRIAFIQ ASWHKEIVDQ CRIAFIAEMA ERGYTEDSID FFEVAGAFEI 70 80 90 100 110 120 PLHAKVLAKS GRYAAVVGTG LVVDGGVYRH EFVSQAVISG LMQVQLETEV PVISAVLTPH 130 140 150 160 HFHSHDEHQN FFFQHFLVKG KEAAHACADT IARLQKIEAL TQERIAA

References

[1]

"Genome analysis of Minibacterium massiliensis highlights the convergent evolution of water-living bacteria." Audic S., Robert C., Campagna B., Parinello H., Claverie J.-M., Raoult D., Drancourt M. PLoS Genet. 3:1454-1463(2007) [PubMed: 17722982] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000269 Genomic DNA. Translation: ABR88799.1.
RefSeq	YP_001353035.1. NC_009659.1.
3D structure databases
ProteinModelPortal	A6SXN8.
SMR	A6SXN8. Positions 15-159.
ModBase	Search...
Protein-protein interaction databases
STRING	A6SXN8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5350406.
GenomeReviews	Gene locus mma_1345 in contig CP000269_GR.
KEGG	mms:mma_1345.
PATRIC	22155151. VBIJanSp106498_1356.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0054.
HOGENOM	HBG311126.
OMA	RRYTAIV.
ProtClustDB	PRK12419.
Family and domain databases
HAMAP	MF_00178. Lumazine_synth. [Tree]
InterPro	IPR002180. DMRL_synthase. [Graphical view]
Gene3D	G3DSA:3.40.50.960. DMRL_synthase. 1 hit.
KO	K00794.
PANTHER	PTHR21058. DMRL_synthase. 1 hit.
Pfam	PF00885. DMRL_synthase. 1 hit. [Graphical view]
SUPFAM	SSF52121. DMRL_synthase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A6SXN8_JANMA

Accession

Primary (citable) accession number: A6SXN8

Entry history

Integrated into UniProtKB/TrEMBL:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)