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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei244ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciJSP375286:G1G65-1173-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:mma_1113
OrganismiJanthinobacterium sp. (strain Marseille) (Minibacterium massiliensis)
Taxonomic identifieri375286 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeJanthinobacterium
Proteomesi
  • UP000006388 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003309761 – 463Glutamate--tRNA ligaseAdd BLAST463

Proteomic databases

PRIDEiA6SX06

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi375286.mma_1113

Structurei

3D structure databases

ProteinModelPortaliA6SX06
SMRiA6SX06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 19"HIGH" regionUniRule annotationAdd BLAST11
Motifi241 – 245"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.8.70, 2 hits
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020752 aa-tRNA-synth_I_codon-bd_sub1
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A6SX06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVRTRFAPS PTGYLHVGGA RTALFSWAYA RHFGGTFVLR IEDTDLERST
60 70 80 90 100
PEAVQAIIEG MEWLGLHHDE GPFYQMQRMD RYREVIGQML AAGTAYHCYS
110 120 130 140 150
SPEEVEAMRE RQRAAGEKPR YDGTWRPEAG KTLPAIPEGR KPVVRFRNPT
160 170 180 190 200
EGDVTWLDVV KGSITISNRE LDDLVIARPD GTPTYNFCVA VDDSDMKITH
210 220 230 240 250
VIRGDDHVNN TPRQINILQA LGATLPHYGH LPMILGTDGE KLSKRHGAVS
260 270 280 290 300
VMDYPAQGYL PEAMLNYLAR LGWSHGDDEV FSMEQFTQWF DLDHLTKSPA
310 320 330 340 350
QFNPEKLDWL NNHYIKQADN TRLAGLVRPM MEGLGAQFEN APDLAAVIAL
360 370 380 390 400
MKERVNTLNE LAVAAMLFYR QPAADAALLA QHLTDAIRPA LAQYVEQLKT
410 420 430 440 450
VAWSKEALSA TLKEVLAAHK LKMPQLAMPL RLLITGQLQT PSIDAVVELF
460
GREVVLARLG KNL
Length:463
Mass (Da):51,793
Last modified:August 21, 2007 - v1
Checksum:iF6FA1D2BD88EC633
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000269 Genomic DNA Translation: ABR88734.1
RefSeqiWP_012078970.1, NC_009659.1

Genome annotation databases

EnsemblBacteriaiABR88734; ABR88734; mma_1113
KEGGimms:mma_1113

Similar proteinsi

Entry informationi

Entry nameiSYE_JANMA
AccessioniPrimary (citable) accession number: A6SX06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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