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A6SV12 (PDXA_JANMA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-hydroxythreonine-4-phosphate dehydrogenase

EC=1.1.1.262
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene names
Name:pdxA
Ordered Locus Names:mma_0419
OrganismJanthinobacterium sp. (strain Marseille) (Minibacterium massiliensis) [Complete proteome] [HAMAP]
Taxonomic identifier375286 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeJanthinobacterium

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity. HAMAP-Rule MF_00536

Catalytic activity

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH. HAMAP-Rule MF_00536

Cofactor

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5. HAMAP-Rule MF_00536

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00536

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00536.

Miscellaneous

The active site is located at the dimer interface By similarity.

Sequence similarities

Belongs to the PdxA family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3433434-hydroxythreonine-4-phosphate dehydrogenase HAMAP-Rule MF_00536
PRO_1000051506

Sites

Metal binding1751Divalent metal cation; shared with dimeric partner By similarity
Metal binding2201Divalent metal cation; shared with dimeric partner By similarity
Metal binding2751Divalent metal cation; shared with dimeric partner By similarity
Binding site1411Substrate By similarity
Binding site1421Substrate By similarity
Binding site2831Substrate By similarity
Binding site2921Substrate By similarity
Binding site3011Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A6SV12 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 6392A8D50C1D01DF

FASTA34335,915
        10         20         30         40         50         60 
MSKRPTIAIT SGEPAGIGPE ISIRAAWELR ADVKSILIGD AAFLAMTAAA INPAIRLSAL 

        70         80         90        100        110        120 
SLQAVRNSGV PDFSRDQIAV IDCPLAAHVV PGKLDAQNGR YVLQTLDIGI EGAQQGWFDA 

       130        140        150        160        170        180 
IVTAPLQKST INDAGVPFTG HTEYLADKTN TAQVVMMLAT NATPQPLRVG LATTHLALKD 

       190        200        210        220        230        240 
VAAAITIDSL AGILDILLAD LQNKFGIAKP RILVAGLNPH AGEGGYLGRE EIEVITPVLQ 

       250        260        270        280        290        300 
AAQAKGFDVR GPYPADTLFQ QKYLEDADCV LAMYHDQGLP VLKYASFGLG VNITLGLPLI 

       310        320        330        340 
RTSVDHGTAL DLAAAGLGQA DHGSMLEAMR IAAQMAAAAR TSS 

« Hide

References

[1]"Genome analysis of Minibacterium massiliensis highlights the convergent evolution of water-living bacteria."
Audic S., Robert C., Campagna B., Parinello H., Claverie J.-M., Raoult D., Drancourt M.
PLoS Genet. 3:1454-1463(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Marseille.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000269 Genomic DNA. Translation: ABR88849.1.
RefSeqYP_001352109.1. NC_009659.1.

3D structure databases

ProteinModelPortalA6SV12.
SMRA6SV12. Positions 1-338.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING375286.mma_0419.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR88849; ABR88849; mma_0419.
GeneID5350463.
KEGGmms:mma_0419.
PATRIC22153273. VBIJanSp106498_0435.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1995.
HOGENOMHOG000221592.
KOK00097.
OMAYVWDTPL.
OrthoDBEOG6GN6ZC.
ProtClustDBPRK01909.

Enzyme and pathway databases

BioCycJSP375286:GJ8U-426-MONOMER.
UniPathwayUPA00244; UER00312.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
HAMAPMF_00536. PdxA.
InterProIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00557. pdxA. 1 hit.
ProtoNetSearch...

Entry information

Entry namePDXA_JANMA
AccessionPrimary (citable) accession number: A6SV12
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways