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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase 1 (folE), GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei154May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciJSP375286:G1G65-347-MONOMER
UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:mma_0332
OrganismiJanthinobacterium sp. (strain Marseille) (Minibacterium massiliensis)
Taxonomic identifieri375286 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeJanthinobacterium
Proteomesi
  • UP000006388 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003165301 – 268GTP cyclohydrolase FolE2Add BLAST268

Interactioni

Protein-protein interaction databases

STRINGi375286.mma_0332

Structurei

3D structure databases

ProteinModelPortaliA6SUS5
SMRiA6SUS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
HOGENOMiHOG000280679
KOiK09007
OMAiHNQRGRG
OrthoDBiPOG091H0MIO

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

A6SUS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTRDPGLAA IPDVQATPDT RRIAIQRVGV KGVRYPLTVK TLSGVQPSVG
60 70 80 90 100
TWNMYVHLAE EQKGTHMSRF IALLEENTQA LDVNVFGGMI RKMLALLEAD
110 120 130 140 150
AGRIEVSFPY FINKTAPVSG VQSLMDYEVG FNGEIKNGKL EITLKVLVPV
160 170 180 190 200
TSLCPCSKKI SAYGAHNQRS HITVQALLAD DLVVEELIAQ IEAQASCELF
210 220 230 240 250
GLLKRPDEKY VTERAYDNPK FVEDLVRDVA VMLNNEARVL AYTLEAENFE
260
SIHNHSAYAL IELDKRLA
Length:268
Mass (Da):29,730
Last modified:August 21, 2007 - v1
Checksum:i24C9E238345AF324
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000269 Genomic DNA Translation: ABR88376.1
RefSeqiWP_012078197.1, NC_009659.1

Genome annotation databases

EnsemblBacteriaiABR88376; ABR88376; mma_0332
KEGGimms:mma_0332

Similar proteinsi

Entry informationi

Entry nameiGCH4_JANMA
AccessioniPrimary (citable) accession number: A6SUS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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