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A6SUS5

- GCH4_JANMA

UniProt

A6SUS5 - GCH4_JANMA

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei154 – 1541May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciJSP375286:GJ8U-339-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:mma_0332
OrganismiJanthinobacterium sp. (strain Marseille) (Minibacterium massiliensis)
Taxonomic identifieri375286 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeJanthinobacterium
ProteomesiUP000006388: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268GTP cyclohydrolase FolE2PRO_0000316530Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi375286.mma_0332.

Structurei

3D structure databases

ProteinModelPortaliA6SUS5.
SMRiA6SUS5. Positions 23-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6SUS5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTRDPGLAA IPDVQATPDT RRIAIQRVGV KGVRYPLTVK TLSGVQPSVG
60 70 80 90 100
TWNMYVHLAE EQKGTHMSRF IALLEENTQA LDVNVFGGMI RKMLALLEAD
110 120 130 140 150
AGRIEVSFPY FINKTAPVSG VQSLMDYEVG FNGEIKNGKL EITLKVLVPV
160 170 180 190 200
TSLCPCSKKI SAYGAHNQRS HITVQALLAD DLVVEELIAQ IEAQASCELF
210 220 230 240 250
GLLKRPDEKY VTERAYDNPK FVEDLVRDVA VMLNNEARVL AYTLEAENFE
260
SIHNHSAYAL IELDKRLA
Length:268
Mass (Da):29,730
Last modified:August 21, 2007 - v1
Checksum:i24C9E238345AF324
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000269 Genomic DNA. Translation: ABR88376.1.
RefSeqiWP_012078197.1. NC_009659.1.
YP_001352022.1. NC_009659.1.

Genome annotation databases

EnsemblBacteriaiABR88376; ABR88376; mma_0332.
GeneIDi5351342.
KEGGimms:mma_0332.
PATRICi22153087. VBIJanSp106498_0342.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000269 Genomic DNA. Translation: ABR88376.1 .
RefSeqi WP_012078197.1. NC_009659.1.
YP_001352022.1. NC_009659.1.

3D structure databases

ProteinModelPortali A6SUS5.
SMRi A6SUS5. Positions 23-265.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 375286.mma_0332.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR88376 ; ABR88376 ; mma_0332 .
GeneIDi 5351342.
KEGGi mms:mma_0332.
PATRICi 22153087. VBIJanSp106498_0342.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci JSP375286:GJ8U-339-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome analysis of Minibacterium massiliensis highlights the convergent evolution of water-living bacteria."
    Audic S., Robert C., Campagna B., Parinello H., Claverie J.-M., Raoult D., Drancourt M.
    PLoS Genet. 3:1454-1463(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Marseille.

Entry informationi

Entry nameiGCH4_JANMA
AccessioniPrimary (citable) accession number: A6SUS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: October 1, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3