A6SUS5 (GCH4_JANMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase folE2
EC=3.5.4.16

Gene names

Name:	folE2
Ordered Locus Names:	mma_0332

Organism

Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis) [Complete proteome] [HAMAP]

Taxonomic identifier

375286 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Oxalobacteraceae › Janthinobacterium

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527
Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527
Sequence similarities	Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	GTP cyclohydrolase folE2 HAMAP-Rule MF_01527		PRO_0000316530
Sites
	Site	154	1	May be catalytically important By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6SUS5 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 24C9E238345AF324	FASTA	268	29,730
	10 20 30 40 50 60 MNTRDPGLAA IPDVQATPDT RRIAIQRVGV KGVRYPLTVK TLSGVQPSVG TWNMYVHLAE 70 80 90 100 110 120 EQKGTHMSRF IALLEENTQA LDVNVFGGMI RKMLALLEAD AGRIEVSFPY FINKTAPVSG 130 140 150 160 170 180 VQSLMDYEVG FNGEIKNGKL EITLKVLVPV TSLCPCSKKI SAYGAHNQRS HITVQALLAD 190 200 210 220 230 240 DLVVEELIAQ IEAQASCELF GLLKRPDEKY VTERAYDNPK FVEDLVRDVA VMLNNEARVL 250 260 AYTLEAENFE SIHNHSAYAL IELDKRLA

References

[1]

"Genome analysis of Minibacterium massiliensis highlights the convergent evolution of water-living bacteria." Audic S., Robert C., Campagna B., Parinello H., Claverie J.-M., Raoult D., Drancourt M. PLoS Genet. 3:1454-1463(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Marseille.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000269 Genomic DNA. Translation: ABR88376.1.
RefSeq	YP_001352022.1. NC_009659.1.
3D structure databases
ProteinModelPortal	A6SUS5.
SMR	A6SUS5. Positions 23-265.
ModBase	Search...
Protein-protein interaction databases
STRING	375286.mma_0332.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABR88376; ABR88376; mma_0332.
GeneID	5351342.
KEGG	mms:mma_0332.
PATRIC	22153087. VBIJanSp106498_0342.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1469.
HOGENOM	HOG000280679.
KO	K09007.
OMA	INMYVDL.
ProtClustDB	PRK13674.
Enzyme and pathway databases
BioCyc	JSP375286:GJ8U-339-MONOMER.
UniPathway	UPA00848; UER00151.
Family and domain databases
Gene3D	3.10.270.10. 1 hit.
HAMAP	MF_01527_B. GTP_cyclohydrol_B.
InterPro	IPR022838. GTP_cyclohydrolase_FolE2. IPR003801. GTP_cyclohydrolase_FolE2/MptA. IPR002042. Uricase. [Graphical view]
Pfam	PF02649. GCHY-1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH4_JANMA

Accession

Primary (citable) accession number: A6SUS5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	August 21, 2007
Last modified:	May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program