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A6SUQ1

- PUR9_JANMA

UniProt

A6SUQ1 - PUR9_JANMA

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, mma_0308
Organism
Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciJSP375286:GJ8U-315-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:mma_0308
OrganismiJanthinobacterium sp. (strain Marseille) (Minibacterium massiliensis)
Taxonomic identifieri375286 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeJanthinobacterium
ProteomesiUP000006388: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018894Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi375286.mma_0308.

Structurei

3D structure databases

ProteinModelPortaliA6SUQ1.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A6SUQ1-1 [UniParc]FASTAAdd to Basket

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MIKQALISVS DKTGVLEFAR ALSGMGVNIL STGGTAKLLA ENGISVTEVA    50
DYTGFPEMLD GRVKTLHPKV HGGILARRDF AEHVSALEKH NIPTIDMVVV 100
NLYPFQQTVA REHCSLEDAI ENIDIGGPAM LRSSAKNHKD VIVICDPTDY 150
SQVLGELSAN QGEVSYETKF TLAKKVFAHT AQYDGAITNY FTSLGADKQH 200
ATRSSYPATL NLHFEKVQEM RYGENPHQSA AFYRESNPQV GALANYTQLQ 250
GKELSYNNIA DADAAWECVK TFDESACVII KHANPCGVAV GASPLEAYSK 300
ALQTDPTSAF GGIIAFNREL DGNAAEAVAK QFVEVLIAPS FSEKAKQIFA 350
GKQNVRLLEI PLGNAVNAHD FKRVGGGLLV QSPDAKNVVL AELKVVSKKQ 400
PTPQQLQDLM FAWRVAKFVK SNAIVFCANG MTMGVGAGQM SRIDSARIAS 450
IKAQNAGLSL VGTAVASDAF FPFRDGLDVV VAAGATSVIH PGGSMRDQEV 500
IDAADEQGVV MLMTGTRHFR H 521
Length:521
Mass (Da):55,986
Last modified:August 21, 2007 - v1
Checksum:i27DCB6CD1F92B496
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000269 Genomic DNA. Translation: ABR88426.1.
RefSeqiWP_012078173.1. NC_009659.1.
YP_001351998.1. NC_009659.1.

Genome annotation databases

EnsemblBacteriaiABR88426; ABR88426; mma_0308.
GeneIDi5350261.
KEGGimms:mma_0308.
PATRICi22153039. VBIJanSp106498_0318.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000269 Genomic DNA. Translation: ABR88426.1 .
RefSeqi WP_012078173.1. NC_009659.1.
YP_001351998.1. NC_009659.1.

3D structure databases

ProteinModelPortali A6SUQ1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 375286.mma_0308.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR88426 ; ABR88426 ; mma_0308 .
GeneIDi 5350261.
KEGGi mms:mma_0308.
PATRICi 22153039. VBIJanSp106498_0318.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci JSP375286:GJ8U-315-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome analysis of Minibacterium massiliensis highlights the convergent evolution of water-living bacteria."
    Audic S., Robert C., Campagna B., Parinello H., Claverie J.-M., Raoult D., Drancourt M.
    PLoS Genet. 3:1454-1463(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Marseille.

Entry informationi

Entry nameiPUR9_JANMA
AccessioniPrimary (citable) accession number: A6SUQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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