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A6SU65 (BIOD_JANMA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP-dependent dethiobiotin synthetase BioD
EC=6.3.3.3
Alternative name(s):
DTB synthetase
Short name=DTBS
Dethiobiotin synthase
Gene names
Name:bioD
Ordered Locus Names:mma_0122
OrganismJanthinobacterium sp. (strain Marseille) (Minibacterium massiliensis) [Complete proteome] [HAMAP]
Taxonomic identifier375286 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Oxalobacteraceae › Janthinobacterium

Protein attributes

Sequence length236 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring By similarity. HAMAP MF_00336

Catalytic activity

ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin. HAMAP MF_00336

Cofactor

Magnesium By similarity. HAMAP MF_00336

Pathway

Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. HAMAP MF_00336

Subcellular location

Cytoplasm By similarity HAMAP MF_00336.

Sequence similarities

Belongs to the dethiobiotin synthetase family.

Ontologies

Keywords
   Biological processBiotin biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processbiotin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

dethiobiotin synthase activity

Inferred from electronic annotation. Source: EC

magnesium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 236236ATP-dependent dethiobiotin synthetase BioD HAMAP MF_00336
PRO_1000019561

Regions

Nucleotide binding122 – 1254ATP By similarity
Nucleotide binding182 – 1832ATP By similarity
Nucleotide binding211 – 2133ATP By similarity

Sites

Metal binding151Magnesium 1 By similarity
Metal binding191Magnesium 2 By similarity
Metal binding611Magnesium 2 By similarity
Metal binding1221Magnesium 2 By similarity
Binding site611ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A6SU65 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 149736B6FD05A446

FASTA23624,488
        10         20         30         40         50         60 
MTATFNCFVT GTDTEIGKTM ISTALLHALV QQGVKAAAIK SVAAGATAIQ TNEGEVWHND 

        70         80         90        100        110        120 
DADALAQAAN VVLPRELATP YLLHEACAPH VSAELQGVAI DIAHIKNCYV QVREMAEAVV 

       130        140        150        160        170        180 
VEGVGGFRVP LSDHADTADL ARELALPVIM VVGLRLGCLN HALLTADAIA ARGLKLVGWV 

       190        200        210        220        230 
ANTVDAGMPF AEDNVAALAA RLSAPLLGCV PRLAAPLPAA AAAYLDFSCL PNWPKA

« Hide

References

[1]"Genome analysis of Minibacterium massiliensis highlights the convergent evolution of water-living bacteria."
Audic S., Robert C., Campagna B., Parinello H., Claverie J.-M., Raoult D., Drancourt M.
PLoS Genet. 3:1454-1463(2007) [PubMed: 17722982] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Marseille.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000269 Genomic DNA. Translation: ABR89188.1.
RefSeqYP_001351812.1. NC_009659.1.

3D structure databases

ProteinModelPortalA6SU65.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6SU65.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5351358.
GenomeReviewsGene locus mma_0122 in contig CP000269_GR.
KEGGmms:mma_0122.
PATRIC22152641. VBIJanSp106498_0126.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0132.
HOGENOMHBG650065.
OMAINPGLSH.
ProtClustDBCLSK966460.

Enzyme and pathway databases

BioCycJSP375286:MMA_0122-MONOMER.

Family and domain databases

HAMAPMF_00336. BioD.
[Tree]
InterProIPR002586. CbiA_P_synth.
IPR004472. DTB_synth_BioD.
[Graphical view]
KOK01935.
PfamPF01656. CbiA. 1 hit.
[Graphical view]
PIRSFPIRSF006755. DTB_synth. 1 hit.
TIGRFAMsTIGR00347. BioD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBIOD_JANMA
AccessionPrimary (citable) accession number: A6SU65
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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