A6SLU6 (A6SLU6_BOTFB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862

Gene names

ORF Names:

BC1G_13785 EMBL EDN19857.1

Organism

Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea) [Complete proteome]

Taxonomic identifier

332648 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Leotiomycetes › Helotiales › Sclerotiniaceae › Botryotinia

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862
Cofactor	FAD By similarity. RuleBase RU003862
Pathway	One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU004254
Sequence similarities	Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Ontologies

Keywords
Ligand	FAD RuleBase RU003862 Flavoprotein RuleBase RU003862
Molecular function	Oxidoreductase RuleBase RU003862
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A6SLU6 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 537F4026BEDFBF1A	FASTA	390	44,083
	10 20 30 40 50 60 MHIKDMLSEA ERSGNPSFSF EFFPPKTAQG VQNLYDRMDR MHGLGPSFID ITWGAGGRLA 70 80 90 100 110 120 QLTCEMVGVA QSQYGLETCM HLTCTDMGKE KVDEALRNAY KAGCTNILAL RGDPPREKEK 130 140 150 160 170 180 WEATEGGFQY AKDLVHHIRQ TYGNHFDIGV AGYPEGCDDQ DDEDLLLDHL KEKVDAGATF 190 200 210 220 230 240 IVTQMFYDVD NFIDWLGKVK ARGVNVPVIP GIMPINTYAS FLRRCNHMGC KIPPKWSAAL 250 260 270 280 290 300 EEVKNDDAAV RNIGKDLVAE MCRRIIEAGV HHLHFYTMNL AQATRMVLEE LSLTPSNQRP 310 320 330 340 350 360 LKHALPWRQS LGLGRREEDV RPIFWKNRNK SYVARTQDWD EFPNGRWGDS RSPAFGELDA 370 380 390 YGIGLKGSNE QNIKLWGQPK SIKDIAELFS

References

[1]

"Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea." Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A., Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E., Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M., Quevillon E. , Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P., Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I., Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P., Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C., Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C., Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E., Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N., Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E., Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O., Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M. PLoS Genet. 7:E1002230-E1002230(2011) [PubMed: 21876677] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: B05.10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH476966 Genomic DNA. Translation: EDN19857.1.
RefSeq	XP_001547755.1. XM_001547705.1.
3D structure databases
ProteinModelPortal	A6SLU6.
ModBase	Search...
Protein-protein interaction databases
STRING	A6SLU6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5428206.
KEGG	bfu:BC1G_13785.
Phylogenomic databases
OMA	ITQMFFD.
OrthoDB	EOG46HKK5.
Family and domain databases
InterPro	IPR004621. Fadh2_euk. IPR003171. Mehydrof_redctse. [Graphical view]
KO	K00297.
Pfam	PF02219. MTHFR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00677. Fadh2_euk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A6SLU6_BOTFB

Accession

Primary (citable) accession number: A6SLU6

Entry history

Integrated into UniProtKB/TrEMBL:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	November 16, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)