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A6SL49

- DAPB_BOTFB

UniProt

A6SL49 - DAPB_BOTFB

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Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei768 – 7681Charge relay systemBy similarity
Active sitei845 – 8451Charge relay systemBy similarity
Active sitei878 – 8781Charge relay systemBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:BC1G_13641
OrganismiBotryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea)
Taxonomic identifieri332648 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeBotrytis

Subcellular locationi

Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 109109CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei110 – 13021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini131 – 921791VacuolarSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 921921Probable dipeptidyl-aminopeptidase BPRO_0000412140Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi822 – 8221N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi332648.A6SL49.

Structurei

3D structure databases

ProteinModelPortaliA6SL49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi79 – 835Poly-Glu

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1506.
KOiK01282.
OMAiETKFWYQ.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

A6SL49-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGHPEENAQ LLSTEQESMS RNSSDSVAST ASTTSLVFDR IGERVAANGS
60 70 80 90 100
EKPTMVTPKF PPRGERAYAD DEHTQIHLEE EEEKDYDMED GAFLTNGATN
110 120 130 140 150
KSVDKKLRRL IWIIGGVFIG AWVLALFIFL GKQAYKHSSE SPHDPQATSS
160 170 180 190 200
RGSGKKVTMD QVMGGQWRAT KHSISWIEGA NGEDGLLLEQ GSVGKDYLIV
210 220 230 240 250
EDVRTQSPSA VGTLDTMTLM KNGYFEVAGR SLTPSKVYPS KDLKKVLVAT
260 270 280 290 300
DVQSNWRHSF YAKYWIFDVE TQTAEPLDPV DLDGRVQLAS WSPKSDAIVF
310 320 330 340 350
TRDNNMYLRK LASPTVVQIT VDGGPEFFYG VPDWVYEEEV FAGASATWWD
360 370 380 390 400
DSGKYIAFLR TNESEVPEYP VQYFVSRPSG KDPLPGEENY PEVREIKYPK
410 420 430 440 450
AGAPNPTVDL LFYDISKAEV FEVKIAGGFE PKDLLITEVV WAGSTGKALI
460 470 480 490 500
RETNRESDVL RVVLVDVVAR EGKTVRFTDI AKLDGGWFEV SEDTRYIPAD
510 520 530 540 550
PANGRPHDGY IDTIIHENYD HLGYFTPMDN SEPILLTSGD WEVVKAPSAV
560 570 580 590 600
DLKNNIVYFI STKESPITRQ LYSVKLDGTD LKAITDTSTE GYYGASFSKG
610 620 630 640 650
AGYVLLNYNG PNIPWQKVIS TPSNDNQYTH IIEENKGLAD MAKKHELPIL
660 670 680 690 700
IYQTVTVDGF ELQVVERRPP HFNPKKKYPV LFYLYGGPGS QTVSKSFGVD
710 720 730 740 750
FQSYIASNLG YIVVTVDGRG TGFIGRKART IIRGNIGHYE ARDQIETAKI
760 770 780 790 800
WASKKYVDES RMAIWGWSYG GFMTLKTLEQ DAGETFSYGM AVAPVTDWRF
810 820 830 840 850
YDSIYTERYM HTPQHNPGGY DNTSISDVKS LAKNVRFLVM HGVADDNVHM
860 870 880 890 900
QNTLTLLDKL DLAGVENYDV HVFPDSDHSI YFHNANRIVY DKLNNWLINA
910 920
FNGEWLRTAN AVPLEIDAAK V
Length:921
Mass (Da):103,088
Last modified:August 21, 2007 - v1
Checksum:i8839279EA0C373D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476961 Genomic DNA. Translation: EDN19610.1.
RefSeqiXP_001547950.1. XM_001547900.1.

Genome annotation databases

GeneIDi5428447.
KEGGibfu:BC1G_13641.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476961 Genomic DNA. Translation: EDN19610.1 .
RefSeqi XP_001547950.1. XM_001547900.1.

3D structure databases

ProteinModelPortali A6SL49.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 332648.A6SL49.

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5428447.
KEGGi bfu:BC1G_13641.

Phylogenomic databases

eggNOGi COG1506.
KOi K01282.
OMAi ETKFWYQ.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea."
    Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A., Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E., Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M., Quevillon E.
    , Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P., Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I., Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P., Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C., Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C., Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E., Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N., Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E., Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O., Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.
    PLoS Genet. 7:E1002230-E1002230(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B05.10.

Entry informationi

Entry nameiDAPB_BOTFB
AccessioniPrimary (citable) accession number: A6SL49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3