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A6SL49

- DAPB_BOTFB

UniProt

A6SL49 - DAPB_BOTFB

Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei768 – 7681Charge relay systemBy similarity
    Active sitei845 – 8451Charge relay systemBy similarity
    Active sitei878 – 8781Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:dapB
    ORF Names:BC1G_13641
    OrganismiBotryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea)
    Taxonomic identifieri332648 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeBotrytis

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 921921Probable dipeptidyl-aminopeptidase BPRO_0000412140Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi822 – 8221N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi332648.A6SL49.

    Structurei

    3D structure databases

    ProteinModelPortaliA6SL49.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 109109CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini131 – 921791VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei110 – 13021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi79 – 835Poly-Glu

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1506.
    KOiK01282.
    OMAiETKFWYQ.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6SL49-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGHPEENAQ LLSTEQESMS RNSSDSVAST ASTTSLVFDR IGERVAANGS    50
    EKPTMVTPKF PPRGERAYAD DEHTQIHLEE EEEKDYDMED GAFLTNGATN 100
    KSVDKKLRRL IWIIGGVFIG AWVLALFIFL GKQAYKHSSE SPHDPQATSS 150
    RGSGKKVTMD QVMGGQWRAT KHSISWIEGA NGEDGLLLEQ GSVGKDYLIV 200
    EDVRTQSPSA VGTLDTMTLM KNGYFEVAGR SLTPSKVYPS KDLKKVLVAT 250
    DVQSNWRHSF YAKYWIFDVE TQTAEPLDPV DLDGRVQLAS WSPKSDAIVF 300
    TRDNNMYLRK LASPTVVQIT VDGGPEFFYG VPDWVYEEEV FAGASATWWD 350
    DSGKYIAFLR TNESEVPEYP VQYFVSRPSG KDPLPGEENY PEVREIKYPK 400
    AGAPNPTVDL LFYDISKAEV FEVKIAGGFE PKDLLITEVV WAGSTGKALI 450
    RETNRESDVL RVVLVDVVAR EGKTVRFTDI AKLDGGWFEV SEDTRYIPAD 500
    PANGRPHDGY IDTIIHENYD HLGYFTPMDN SEPILLTSGD WEVVKAPSAV 550
    DLKNNIVYFI STKESPITRQ LYSVKLDGTD LKAITDTSTE GYYGASFSKG 600
    AGYVLLNYNG PNIPWQKVIS TPSNDNQYTH IIEENKGLAD MAKKHELPIL 650
    IYQTVTVDGF ELQVVERRPP HFNPKKKYPV LFYLYGGPGS QTVSKSFGVD 700
    FQSYIASNLG YIVVTVDGRG TGFIGRKART IIRGNIGHYE ARDQIETAKI 750
    WASKKYVDES RMAIWGWSYG GFMTLKTLEQ DAGETFSYGM AVAPVTDWRF 800
    YDSIYTERYM HTPQHNPGGY DNTSISDVKS LAKNVRFLVM HGVADDNVHM 850
    QNTLTLLDKL DLAGVENYDV HVFPDSDHSI YFHNANRIVY DKLNNWLINA 900
    FNGEWLRTAN AVPLEIDAAK V 921
    Length:921
    Mass (Da):103,088
    Last modified:August 21, 2007 - v1
    Checksum:i8839279EA0C373D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476961 Genomic DNA. Translation: EDN19610.1.
    RefSeqiXP_001547950.1. XM_001547900.1.

    Genome annotation databases

    GeneIDi5428447.
    KEGGibfu:BC1G_13641.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476961 Genomic DNA. Translation: EDN19610.1 .
    RefSeqi XP_001547950.1. XM_001547900.1.

    3D structure databases

    ProteinModelPortali A6SL49.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 332648.A6SL49.

    Protein family/group databases

    MEROPSi S09.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5428447.
    KEGGi bfu:BC1G_13641.

    Phylogenomic databases

    eggNOGi COG1506.
    KOi K01282.
    OMAi ETKFWYQ.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea."
      Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A., Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E., Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M., Quevillon E.
      , Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P., Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I., Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P., Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C., Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C., Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E., Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N., Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E., Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O., Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.
      PLoS Genet. 7:E1002230-E1002230(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B05.10.

    Entry informationi

    Entry nameiDAPB_BOTFB
    AccessioniPrimary (citable) accession number: A6SL49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3