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A6RUD7

- CBPYA_BOTFB

UniProt

A6RUD7 - CBPYA_BOTFB

Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei273 – 2731By similarity
    Active sitei465 – 4651By similarity
    Active sitei523 – 5231By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:CPYA
    ORF Names:BC1G_03711
    OrganismiBotryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea)
    Taxonomic identifieri332648 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeBotrytis

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 132115By similarityPRO_0000407441Add
    BLAST
    Chaini133 – 546414Carboxypeptidase Y homolog APRO_0000407442Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi186 ↔ 426By similarity
    Glycosylationi217 – 2171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi320 ↔ 334By similarity
    Disulfide bondi344 ↔ 367By similarity
    Disulfide bondi351 ↔ 360By similarity
    Disulfide bondi389 ↔ 396By similarity
    Glycosylationi512 – 5121N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Interactioni

    Protein-protein interaction databases

    STRINGi332648.A6RUD7.

    Structurei

    3D structure databases

    ProteinModelPortaliA6RUD7.
    SMRiA6RUD7. Positions 135-542.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2939.
    KOiK13289.
    OMAiWPGQKEY.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A6RUD7-1 [UniParc]FASTAAdd to Basket

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    MKLLASTVLV GAAAASITPQ QQVLQNPFKS ATKPVSDAWS KSMESLGHLT    50
    GSMKGMTAEA KAIWDEVSML FPEAMEKAAF FSEPKPHTRK PDSTWDYIVK 100
    GADIQSVWVE NSKGEKEREI DGKLEQYNLR AKKVDPSKLG VDTVKQYSGY 150
    LDDEEDDKHL FYWFFESRND PKNDPVVLWL NGGPGCSSLT GLFLELGPSS 200
    IDKNLKLHNN PYSWNANASV IFLDQPVNVG YSYSGSSVSN TVAAGKDVYA 250
    LLTLFFKQFP EYAKQDFHIA GESYAGHYIP VFTSEILSHK KRNINLKSVL 300
    IGNGLTDGLT QYEHYRPMAC GDGGWPAVLG ASECQAMDNA LPRCQSLIQN 350
    CYDSESVWSC VPASIYCNNA MMGPYQRTGQ NVYDVRGKCE DTSNLCYSAL 400
    GWISEFLNKA DVQKELGVEV SSYDSCNFDI NRNFLFQGDW MKPFHRLVPG 450
    ILEQIPVLIY AGDADFICNW LGNQAWTDAL EWPGKKDFNA AKTKDLQLES 500
    GHKTGTFKSS GNFTFARIFG AGHMVPMDQP EASLDFLNKW LNDYTL 546
    Length:546
    Mass (Da):60,852
    Last modified:August 21, 2007 - v1
    Checksum:i57286623880833A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476857 Genomic DNA. Translation: EDN21690.1.
    RefSeqiXP_001557447.1. XM_001557397.1.

    Genome annotation databases

    GeneIDi5438040.
    KEGGibfu:BC1G_03711.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476857 Genomic DNA. Translation: EDN21690.1 .
    RefSeqi XP_001557447.1. XM_001557397.1.

    3D structure databases

    ProteinModelPortali A6RUD7.
    SMRi A6RUD7. Positions 135-542.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 332648.A6RUD7.

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5438040.
    KEGGi bfu:BC1G_03711.

    Phylogenomic databases

    eggNOGi COG2939.
    KOi K13289.
    OMAi WPGQKEY.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea."
      Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A., Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E., Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M., Quevillon E.
      , Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P., Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I., Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P., Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C., Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C., Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E., Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N., Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E., Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O., Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.
      PLoS Genet. 7:E1002230-E1002230(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B05.10.

    Entry informationi

    Entry nameiCBPYA_BOTFB
    AccessioniPrimary (citable) accession number: A6RUD7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3