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A6RUD7 (CBPYA_BOTFB) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carboxypeptidase Y homolog A

EC=3.4.16.5
Gene names
Name:CPYA
ORF Names:BC1G_03711
OrganismBotryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea)
Taxonomic identifier332648 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeBotrytis

Protein attributes

Sequence length546 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activity

Release of a C-terminal amino acid with broad specificity.

Subcellular location

Vacuole By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Cellular componentVacuole
   DomainSignal
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMDisulfide bond
Glycoprotein
Zymogen
Gene Ontology (GO)
   Cellular_componentvacuole

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Propeptide18 – 132115 By similarity
PRO_0000407441
Chain133 – 546414Carboxypeptidase Y homolog A
PRO_0000407442

Sites

Active site2731 By similarity
Active site4651 By similarity
Active site5231 By similarity

Amino acid modifications

Glycosylation2171N-linked (GlcNAc...) Potential
Glycosylation5121N-linked (GlcNAc...) Potential
Disulfide bond186 ↔ 426 By similarity
Disulfide bond320 ↔ 334 By similarity
Disulfide bond344 ↔ 367 By similarity
Disulfide bond351 ↔ 360 By similarity
Disulfide bond389 ↔ 396 By similarity

Sequences

Sequence LengthMass (Da)Tools
A6RUD7 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 57286623880833A9

FASTA54660,852
        10         20         30         40         50         60 
MKLLASTVLV GAAAASITPQ QQVLQNPFKS ATKPVSDAWS KSMESLGHLT GSMKGMTAEA 

        70         80         90        100        110        120 
KAIWDEVSML FPEAMEKAAF FSEPKPHTRK PDSTWDYIVK GADIQSVWVE NSKGEKEREI 

       130        140        150        160        170        180 
DGKLEQYNLR AKKVDPSKLG VDTVKQYSGY LDDEEDDKHL FYWFFESRND PKNDPVVLWL 

       190        200        210        220        230        240 
NGGPGCSSLT GLFLELGPSS IDKNLKLHNN PYSWNANASV IFLDQPVNVG YSYSGSSVSN 

       250        260        270        280        290        300 
TVAAGKDVYA LLTLFFKQFP EYAKQDFHIA GESYAGHYIP VFTSEILSHK KRNINLKSVL 

       310        320        330        340        350        360 
IGNGLTDGLT QYEHYRPMAC GDGGWPAVLG ASECQAMDNA LPRCQSLIQN CYDSESVWSC 

       370        380        390        400        410        420 
VPASIYCNNA MMGPYQRTGQ NVYDVRGKCE DTSNLCYSAL GWISEFLNKA DVQKELGVEV 

       430        440        450        460        470        480 
SSYDSCNFDI NRNFLFQGDW MKPFHRLVPG ILEQIPVLIY AGDADFICNW LGNQAWTDAL 

       490        500        510        520        530        540 
EWPGKKDFNA AKTKDLQLES GHKTGTFKSS GNFTFARIFG AGHMVPMDQP EASLDFLNKW 


LNDYTL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476857 Genomic DNA. Translation: EDN21690.1.
RefSeqXP_001557447.1. XM_001557397.1.

3D structure databases

ProteinModelPortalA6RUD7.
SMRA6RUD7. Positions 135-542.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING332648.A6RUD7.

Protein family/group databases

MEROPSS10.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5438040.
KEGGbfu:BC1G_03711.

Phylogenomic databases

eggNOGCOG2939.
KOK13289.
OMAWPGQKEY.

Family and domain databases

Gene3D3.40.50.1820. 2 hits.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCBPYA_BOTFB
AccessionPrimary (citable) accession number: A6RUD7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: August 21, 2007
Last modified: July 9, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries