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A6RQM1 (A6RQM1_BOTFB) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
ORF Names:BC1G_02744 EMBL EDN33066.1
OrganismBotryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea) [Complete proteome]
Taxonomic identifier332648 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Leotiomycetes › Helotiales › Sclerotiniaceae › Botryotinia

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding14 – 196NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding37 – 393NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding79 – 813NADP By similarity PIRSR PIRSR000109-3
Region133 – 1353Substrate binding By similarity PIRSR PIRSR000109-2
Region190 – 1912Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1871Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1941Proton donor By similarity PIRSR PIRSR000109-1
Binding site1071NADP By similarity PIRSR PIRSR000109-3
Binding site1071Substrate By similarity PIRSR PIRSR000109-2
Binding site1951Substrate By similarity PIRSR PIRSR000109-2
Binding site2641Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2911Substrate By similarity PIRSR PIRSR000109-2
Binding site4511Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4571Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
A6RQM1 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: A0DE4668B141C89E

FASTA49454,710
        10         20         30         40         50         60 
MSAPQATGDF GLIGLAVMGQ NIILNAADHG FNVIAFNRTT SKVDRFLENE AKGKSIEGAH 

        70         80         90        100        110        120 
SIEEFCAKLK KPRRIMLLVM AGKPVDDFIE TILPHIEEGD IIIDGGNSHF PDTNRRTKYL 

       130        140        150        160        170        180 
AQKGIRFVGS GVSGGEEGAR YGPSLMPGGN EEAWPYIKDV FQSIAAKSDG EACCEWVGDE 

       190        200        210        220        230        240 
GAGHYVKMVH NGIEYGDMQL ICEAYDIMKR GLGMQDKEIG DVFAEWNKGV LDSFLIEITR 

       250        260        270        280        290        300 
DIMYFNDDDG TPLLEKIMDS AGQKGTGKWT AINALDLGMP VTLIAESVLS RCLSSLKEER 

       310        320        330        340        350        360 
TRASKVLSYV GRSNKFEGDK KQFLEDLEQA LYASKIISYA QGFMLMQEAA KEFKWKLNKP 

       370        380        390        400        410        420 
SIALMWRGGC IIRSVFLKDI TAAYRADDNL ENLLFSDFFN KAIHKAQPGW RDVVSKSALM 

       430        440        450        460        470        480 
GIPTPAFSTA LSWFDGYRTK DLPANLLQAQ RDYFGAHTFK IKPEHASEKY PVGKDIHVNW 

       490 
TGRGGNVSAS TYQA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CH476850 Genomic DNA. Translation: EDN33066.1.
RefSeqXP_001558673.1. XM_001558623.1.

3D structure databases

ProteinModelPortalA6RQM1.
SMRA6RQM1. Positions 7-481.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6RQM1.

2D gel databases

World-2DPAGE0005:A6RQM1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5439237.
KEGGbfu:BC1G_02744.

Phylogenomic databases

OMAITKAYRE.
OrthoDBEOG4VDT6Z.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA6RQM1_BOTFB
AccessionPrimary (citable) accession number: A6RQM1
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info