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A6RPN7

- BGALB_BOTFB

UniProt

A6RPN7 - BGALB_BOTFB

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Protein
Probable beta-galactosidase B
Gene
lacB, BC1G_02410
Organism
Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871Substrate By similarity
Binding sitei132 – 1321Substrate By similarity
Binding sitei133 – 1331Substrate; via amide nitrogen By similarity
Binding sitei134 – 1341Substrate By similarity
Binding sitei192 – 1921Substrate By similarity
Active sitei193 – 1931Proton donor Reviewed prediction
Binding sitei262 – 2621Substrate By similarity
Active sitei305 – 3051Nucleophile Reviewed prediction
Binding sitei370 – 3701Substrate By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase B (EC:3.2.1.23)
Alternative name(s):
Lactase B
Gene namesi
Name:lacB
ORF Names:BC1G_02410
OrganismiBotryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea)
Taxonomic identifieri332648 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeBotrytis

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 1007989Probable beta-galactosidase B
PRO_0000395228Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi23 – 231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi155 – 1551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi208 – 2081N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi268 ↔ 321 By similarity
Glycosylationi269 – 2691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi409 – 4091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi453 – 4531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi594 – 5941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi624 – 6241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi681 – 6811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi703 – 7031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi787 – 7871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi815 – 8151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi825 – 8251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi878 – 8781N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi332648.A6RPN7.

Structurei

3D structure databases

ProteinModelPortaliA6RPN7.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1874.
OMAiYINANTS.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6RPN7-1 [UniParc]FASTAAdd to Basket

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MRLQSLFASA LTLGSCVAQN STNGTWPIHN NGLTTQIEWD HYSMIVNGQR     50
FFLWSGELHY WRIPVPELWV DVLQKIKAAG FNTFAIYTHW YFHNPNPETL 100
DFENAAHDFT KIFDLAKELG MYVVFRPGPY VNAESNAGAF PLWLTTGAYG 150
SLRNNDTRYT EAWTPFWEKV ASIVAPYQLT NGGNVLTYQI ENELGSQWRG 200
TPSKKIPNLS SIQYMEALEA SARAQGITIP FQANDPNLNS DSWSKDFYDG 250
YGSVDIYGMD SYPACWTCNL TECDSTNGAY KPFNVIDYYD HFQEISPTQP 300
SFLPEFQGGS FNPWGGPEGG CPENSPADFA NLFYRNNVGQ RVTAMSLYML 350
YGGTNWGWLA APVVATSYDY SSPISENRMI NDKYAETKLF GQFLRVAKDL 400
TKTDRIGTNQ TASTNPNIVY SEIRNPDTNG AFYVTIHQES TVGTREEFYI 450
NANTSKGEFT IPQKAAPIVL NGFQSKIIVT DFSFGSHSLL YSTAEVLSHS 500
IVDEEDILAL WMPTGEAGEF VVTGAKSGKV SSCGGCSSVG FYPQGDDLLV 550
TISQSEGISI LTFDDGLRVL VMDRSYAYEF WVPVLTADPF SPANETVFVQ 600
GPSLVRSVAY SSDGTILELT GDNNGTSTQI EVFPPKAVSE VTWNGQSIKT 650
SKTDYGSLIG SLTAPALDSL TLPEISGWKA NDSLPERLST YDDSWWVDAN 700
HMNTSNPTKP ETLPVLYIDD YGYHVGNHLW RGRFEGSASG VYLSVTGGRA 750
FGYSAWLNGE FIGSYVGAAY PDTGELTLSF GNLASSNSTN ILLVLQDNSG 800
HDETSGALNP RGINNATLIS SSAKNFTSWK VTGTAGKPDT AIDPVRGILS 850
EGGLYAERLG WHLPGFDDSE WSSASPSNIS SSAGVTFYRT TVPLAIPTGL 900
DVAISFTLNA SPSNAALRAL LFVNGYQYGR FSPWIGNQIE FPVPPGILNY 950
DGDNVIGLSV WRQEEGGESM GVDVGWKITE AFASSFEPIF DATYLQPGWT 1000
EERLQYA 1007
Length:1,007
Mass (Da):110,544
Last modified:August 21, 2007 - v1
Checksum:iB78768183EDEE67F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476848 Genomic DNA. Translation: EDN31260.1.
RefSeqiXP_001559246.1. XM_001559196.1.

Genome annotation databases

GeneIDi5439872.
KEGGibfu:BC1G_02410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476848 Genomic DNA. Translation: EDN31260.1 .
RefSeqi XP_001559246.1. XM_001559196.1.

3D structure databases

ProteinModelPortali A6RPN7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 332648.A6RPN7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5439872.
KEGGi bfu:BC1G_02410.

Phylogenomic databases

eggNOGi COG1874.
OMAi YINANTS.

Family and domain databases

Gene3Di 2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PRINTSi PR00742. GLHYDRLASE35.
SUPFAMi SSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea."
    Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A., Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E., Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M., Quevillon E.
    , Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P., Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I., Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P., Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C., Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C., Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E., Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N., Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E., Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O., Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.
    PLoS Genet. 7:E1002230-E1002230(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B05.10.

Entry informationi

Entry nameiBGALB_BOTFB
AccessioniPrimary (citable) accession number: A6RPN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: August 21, 2007
Last modified: July 9, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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