Reviewed, UniProtKB/Swiss-Prot A6RHI1 (KAD1_AJECN)

Names and origin

Protein names

Recommended name:
    Adenylate kinase 1
      Short name=AK 1
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase 1
    Adenylate kinase cytosolic and mitochondrial

Gene names

Name:	ADK1
ORF Names:	HCAG_09104

Organism

Ajellomyces capsulata (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)

Taxonomic identifier

339724 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › Ajellomycetaceae › Ajellomyces

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Functions both in cytoplasm and mitochondrion intermembrane space By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm › cytosol By similarity. Mitochondrion intermembrane space By similarity.
Sequence similarities	Belongs to the adenylate kinase family. AK2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Adenylate kinase 1		PRO_0000365657
Regions
	Nucleotide binding	52 – 60	9	ATP By similarity
	Nucleotide binding	75 – 104	30	AMP By similarity
Sites
	Binding site	76	1	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6RHI1-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: BAEE9F3392ECE7CE	FASTA	277	30,387
	10 20 30 40 50 60 MAPIKDETID GLKSIISELE SRVVQLEGRL LHGGGSSQPK SITDSVRMIL MGPPGAGKGT 70 80 90 100 110 120 QAPKIKDKFC VCHLATGDML RSQVARKTEL GKEAKKIMDQ GGLVSDEIMV NMIKHELENN 130 140 150 160 170 180 KECQNGFILD GFPRTVAQAE RLDSMLNSRG QKLQHAVELQ IDDSLLVARI TGRLVHPASG 190 200 210 220 230 240 RSYHKIFNPP KEAMKDDVTG EPLIQRSDDN ADALKKRLKT YHSQTEPVVG YYKTTGIWRG 250 260 270 IDASQEPGQV WKSLLQVFDA DKAASSSGIL DKIGLSK

References

[1]

"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives." Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W. Genome Res. 19:1722-1731(2009) [PubMed: 19717792] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CH476673 Genomic DNA. Translation: EDN05485.1.
RefSeq	XP_001535964.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5442314.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_Znf_lid. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
ProDom	PD000657. Adenylate_kin. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD1_AJECN

Accession

Primary (citable) accession number: A6RHI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	August 21, 2007
Last modified:	November 3, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)