A6RGF3 (MTLD_AJECN) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 30.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Mannitol-1-phosphate 5-dehydrogenase Short name=M1PDH Short name=MPD Short name=MPDH EC=1.1.1.17 | ||
| Gene names |
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| Organism | Ajellomyces capsulata (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum) [Complete proteome] | ||
| Taxonomic identifier | 339724 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › Ajellomycetaceae › Ajellomyces |
Protein attributes
| Sequence length | 388 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway By similarity. |
| Catalytic activity | D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. |
| Subunit structure | Monomer By similarity. |
| Sequence similarities | Belongs to the mannitol dehydrogenase family. |
| Sequence caution | The sequence EDN05065.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Molecular function | coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activityInferred from electronic annotation. Source: EC nucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives." Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. Taylor J.W.Genome Res. 19:1722-1731(2009) [PubMed: 19717792] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NAm1 / WU24. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CH476666 Genomic DNA. Translation: EDN05065.1. Different initiation. |
| RefSeq | XP_001536398.1. XM_001536348.1. |
3D structure databases | |
| ProteinModelPortal | A6RGF3. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 5442776. |
Family and domain databases | |
| InterPro | IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR023028. Mannitol_1_phos_5_DH. IPR000669. Mannitol_DH. IPR013118. Mannitol_DH_C. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit. |
| Pfam | PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view] |
| PRINTS | PR00084. MTLDHDRGNASE. |
| SUPFAM | SSF48179. 6DGDH_C_like. 1 hit. |
| PROSITE | PS00974. MANNITOL_DHGENASE. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MTLD_AJECN | ||||||||
| Accession | Primary (citable) accession number: A6RGF3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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