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Reviewed, UniProtKB/Swiss-Prot A6RGF3 (MTLD_AJECN)

Last modified November 3, 2009. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Mannitol-1-phosphate 5-dehydrogenase
      Short name=M1PDH
      Short name=MPDH
      Short name=MPD
    EC=1.1.1.17
Gene names
ORF Names: HCAG_08720
OrganismAjellomyces capsulata (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Taxonomic identifier339724 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway By similarity.

Catalytic activity

D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol-1-phosphate 5-dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Mannitol-1-phosphate 5-dehydrogenase
PRO_0000371516

Regions

Nucleotide binding5 – 1612NAD By similarity

Sites

Active site2131 By similarity

Sequences

Sequence LengthMass (Da)Tools
A6RGF3-1 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 4EB793D2DFFEDF7C

FASTA38843,148
        10         20         30         40         50         60 
MGKKAVHFGG GNIGRGFVGE FLHESGYEVV FVDVMDNVID ALNKHSSYTV TEISEEGEQQ 

        70         80         90        100        110        120 
KVITNYRAIN SKHNLDDVIK EISTADVVTC AVGPNILKFI APPIAKGIDT RTLSKPLAVI 

       130        140        150        160        170        180 
ACENAIGATD TLHGFIKENT DEARLPSLYS RAQFANSAID RIVPTQDLGS GLNVKIEKFY 

       190        200        210        220        230        240 
EWVVEKTPFG DVGHPDIKDI HWVDNLEPYI ERKLFTVNTG HATAAYYGYS AGKKTIHDAL 

       250        260        270        280        290        300 
RDDRIRKEVN AALAETSRLI VEKHGISPEE QARYVSSIIT RISNPHLEDI VQRVGRAPLR 

       310        320        330        340        350        360 
KLSRKERFIG PASQLAERGH TVTALMDAVE QALKFQNVPD DEESFELFKI LKENSAADAT 

       370        380 
TKLTGLEKEH PLYSRVLEKV DKVQKETK 

« Hide

References

Cross-references

Sequence databases

CH476666 Genomic DNA. Translation: EDN05065.1. Different initiation.
RefSeqXP_001536398.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID5442776.

Family and domain databases

InterProIPR013328. DH_multihelical.
IPR013118. Mannitol_DH_C.
IPR000669. Mannitol_DH_core.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
PROSITEPS00974. MANNITOL_DHGENASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLD_AJECN
AccessionPrimary (citable) accession number: A6RGF3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: November 3, 2009
This is version 18 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents