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A6RGC8

- MAP2_AJECN

UniProt

A6RGC8 - MAP2_AJECN

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Protein

Methionine aminopeptidase 2

Gene

HCAG_08694

Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei216 – 2161SubstrateUniRule annotation
Metal bindingi237 – 2371Divalent metal cation 1UniRule annotation
Metal bindingi248 – 2481Divalent metal cation 1UniRule annotation
Metal bindingi248 – 2481Divalent metal cation 2; catalyticUniRule annotation
Metal bindingi317 – 3171Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation
Binding sitei325 – 3251SubstrateUniRule annotation
Metal bindingi350 – 3501Divalent metal cation 2; catalyticUniRule annotation
Metal bindingi445 – 4451Divalent metal cation 1UniRule annotation
Metal bindingi445 – 4451Divalent metal cation 2; catalyticUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2UniRule annotation (EC:3.4.11.18UniRule annotation)
Short name:
MAP 2UniRule annotation
Short name:
MetAP 2UniRule annotation
Alternative name(s):
Peptidase MUniRule annotation
Gene namesi
ORF Names:HCAG_08694
OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Taxonomic identifieri339724 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
ProteomesiUP000009297: Unassembled WGS sequence

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464Methionine aminopeptidase 2PRO_0000407641Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA6RGC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi78 – 825Poly-Lys

Sequence similaritiesi

Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.UniRule annotation

Phylogenomic databases

KOiK01265.
OrthoDBiEOG7BGHW3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPiMF_03175. MetAP_2_euk.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 2 hits.
TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.
PROSITEiPS01202. MAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6RGC8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSKTPGNHR RGPNESSPHP AIDAINPPKQ AAASRLVHSS LEGESEGGED
60 70 80 90 100
EDDDKPGADL KAVGQIGNNG QKRNKRRKKK KKNTKELEIL QTTPPRVALA
110 120 130 140 150
NIFRSQRYPE AEIVKYSTDN DNLQRTTAEE LRHISVLNAM DDEFLNDYRK
160 170 180 190 200
AAEVHRQVRQ YVQTIIKPGI ALSQLAEEIE DGVRALTNHQ GLETGDALKA
210 220 230 240 250
GMAFPTGLCL NNIAAHWTPN PGAKEVILKY DDVLKIDFGV HVNGRIVDSA
260 270 280 290 300
FTIAFNPVYD NLLAAVKDAT NAGLKEAGID ARIAHISETI QNVMESYEVE
310 320 330 340 350
LNQKVIPVKA VRNITGHNVL HYKIHGDKQV PFVKTQTNQR MEEGDVFAIE
360 370 380 390 400
TFGSTGKAYL DDATGIYGYG YDENASTAGL HHSSAKSLLK TIKENFGTLV
410 420 430 440 450
FSRRYLERLG VQRYHLGMRS LVTNGIVQSY APLVDVPGSY VAQFEHTVLL
460
RPNCKEVISR GDDY
Length:464
Mass (Da):51,306
Last modified:August 21, 2007 - v1
Checksum:iA07E43839397E551
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476666 Genomic DNA. Translation: EDN05040.1.
RefSeqiXP_001536373.1. XM_001536323.1.

Genome annotation databases

GeneIDi5442741.
KEGGiaje:HCAG_08694.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476666 Genomic DNA. Translation: EDN05040.1 .
RefSeqi XP_001536373.1. XM_001536323.1.

3D structure databases

ProteinModelPortali A6RGC8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5442741.
KEGGi aje:HCAG_08694.

Phylogenomic databases

KOi K01265.
OrthoDBi EOG7BGHW3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPi MF_03175. MetAP_2_euk.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 2 hits.
TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
PROSITEi PS01202. MAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NAm1 / WU24.

Entry informationi

Entry nameiMAP2_AJECN
AccessioniPrimary (citable) accession number: A6RGC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3