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A6RGA0

- CBPYA_AJECN

UniProt

A6RGA0 - CBPYA_AJECN

Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei266 – 2661PROSITE-ProRule annotation
    Active sitei457 – 4571PROSITE-ProRule annotation
    Active sitei518 – 5181PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:CPYA
    ORF Names:HCAG_08666
    OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
    Taxonomic identifieri339724 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
    ProteomesiUP000009297: Unassembled WGS sequence

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 125107By similarityPRO_0000407418Add
    BLAST
    Chaini126 – 545420Carboxypeptidase Y homolog APRO_0000407419Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi179 ↔ 418By similarity
    Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi313 ↔ 327By similarity
    Disulfide bondi337 ↔ 360By similarity
    Disulfide bondi344 ↔ 353By similarity
    Disulfide bondi382 ↔ 388By similarity
    Glycosylationi487 – 4871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi507 – 5071N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Structurei

    3D structure databases

    ProteinModelPortaliA6RGA0.
    SMRiA6RGA0. Positions 125-541.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    KOiK13289.
    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A6RGA0-1 [UniParc]FASTAAdd to Basket

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    MKSSLALALL VGGAIASGPQ QQVLREPVDH PQAAETPLQK ISDIFGHLSE    50
    QAGNVWEDVM DKFPDTLMDA ITQTPPPKKH NRRPDSEWDH IVRGSDVQAV 100
    WVEGDAGEKH RKVGGRLDTY DLRVKAVDPS NLGVDTVKQY SGYLDDNEND 150
    KHLFYWFFES RNDPKNDPVV LWLNGGPGCS SLTGLFLELG PSSITKQLKV 200
    EYNEFSWNSN ASVIFLDQPV NVGYSYSSSS VSNTQAAAKD VYALLTLFFE 250
    QFPEYSRQDF HIAGESYAGH YIPVFASEIM SHSHRNINLK SILVGNGLTD 300
    PLSQYPHYRP MACGEGGYPA VLSSSSCQAM DNALPRCLAM IQACYNTESR 350
    WSCVPASIYC NNALIGPYQR SGMNPYDVRS KCEGGSLCYT QLDDISKYLN 400
    RNAVMESLGA EVSSYESCNM DINRNFLFQG DWMQPYMRVV PTLLAQMPVL 450
    IYAGDADFIC NWLGNKAWTE ALEYPGHNEF AAAEMKNLTS QNHEDVRVIG 500
    QVKSAGNFTF MRLFGGGHMV PMDQPEASLE FFNRWLGGEW SDKSP 545
    Length:545
    Mass (Da):60,747
    Last modified:August 21, 2007 - v1
    Checksum:i4E49F04D1C55BB8D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476666 Genomic DNA. Translation: EDN05012.1.
    RefSeqiXP_001536345.1. XM_001536295.1.

    Genome annotation databases

    GeneIDi5442623.
    KEGGiaje:HCAG_08666.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476666 Genomic DNA. Translation: EDN05012.1 .
    RefSeqi XP_001536345.1. XM_001536295.1.

    3D structure databases

    ProteinModelPortali A6RGA0.
    SMRi A6RGA0. Positions 125-541.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5442623.
    KEGGi aje:HCAG_08666.

    Phylogenomic databases

    KOi K13289.
    OrthoDBi EOG7XDBR1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NAm1 / WU24.

    Entry informationi

    Entry nameiCBPYA_AJECN
    AccessioniPrimary (citable) accession number: A6RGA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3