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A6RGA0

- CBPYA_AJECN

UniProt

A6RGA0 - CBPYA_AJECN

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Protein

Carboxypeptidase Y homolog A

Gene
CPYA, HCAG_08666
Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei266 – 2661 By similarity
Active sitei457 – 4571 By similarity
Active sitei518 – 5181 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:HCAG_08666
OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Taxonomic identifieri339724 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
ProteomesiUP000009297: Unassembled WGS sequence

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Propeptidei19 – 125107 By similarityPRO_0000407418Add
BLAST
Chaini126 – 545420Carboxypeptidase Y homolog APRO_0000407419Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi179 ↔ 418 By similarity
Glycosylationi210 – 2101N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi313 ↔ 327 By similarity
Disulfide bondi337 ↔ 360 By similarity
Disulfide bondi344 ↔ 353 By similarity
Disulfide bondi382 ↔ 388 By similarity
Glycosylationi487 – 4871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi507 – 5071N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Structurei

3D structure databases

ProteinModelPortaliA6RGA0.
SMRiA6RGA0. Positions 125-541.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Phylogenomic databases

KOiK13289.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6RGA0-1 [UniParc]FASTAAdd to Basket

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MKSSLALALL VGGAIASGPQ QQVLREPVDH PQAAETPLQK ISDIFGHLSE    50
QAGNVWEDVM DKFPDTLMDA ITQTPPPKKH NRRPDSEWDH IVRGSDVQAV 100
WVEGDAGEKH RKVGGRLDTY DLRVKAVDPS NLGVDTVKQY SGYLDDNEND 150
KHLFYWFFES RNDPKNDPVV LWLNGGPGCS SLTGLFLELG PSSITKQLKV 200
EYNEFSWNSN ASVIFLDQPV NVGYSYSSSS VSNTQAAAKD VYALLTLFFE 250
QFPEYSRQDF HIAGESYAGH YIPVFASEIM SHSHRNINLK SILVGNGLTD 300
PLSQYPHYRP MACGEGGYPA VLSSSSCQAM DNALPRCLAM IQACYNTESR 350
WSCVPASIYC NNALIGPYQR SGMNPYDVRS KCEGGSLCYT QLDDISKYLN 400
RNAVMESLGA EVSSYESCNM DINRNFLFQG DWMQPYMRVV PTLLAQMPVL 450
IYAGDADFIC NWLGNKAWTE ALEYPGHNEF AAAEMKNLTS QNHEDVRVIG 500
QVKSAGNFTF MRLFGGGHMV PMDQPEASLE FFNRWLGGEW SDKSP 545
Length:545
Mass (Da):60,747
Last modified:August 21, 2007 - v1
Checksum:i4E49F04D1C55BB8D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476666 Genomic DNA. Translation: EDN05012.1.
RefSeqiXP_001536345.1. XM_001536295.1.

Genome annotation databases

GeneIDi5442623.
KEGGiaje:HCAG_08666.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476666 Genomic DNA. Translation: EDN05012.1 .
RefSeqi XP_001536345.1. XM_001536295.1.

3D structure databases

ProteinModelPortali A6RGA0.
SMRi A6RGA0. Positions 125-541.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5442623.
KEGGi aje:HCAG_08666.

Phylogenomic databases

KOi K13289.
OrthoDBi EOG7XDBR1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NAm1 / WU24.

Entry informationi

Entry nameiCBPYA_AJECN
AccessioniPrimary (citable) accession number: A6RGA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: August 21, 2007
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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