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Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei266PROSITE-ProRule annotation1
Active sitei457PROSITE-ProRule annotation1
Active sitei518PROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:HCAG_08666
OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Taxonomic identifieri339724 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeHistoplasma
Proteomesi
  • UP000009297 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:HCAG_08666.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000040741819 – 125By similarityAdd BLAST107
ChainiPRO_0000407419126 – 545Carboxypeptidase Y homolog AAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi179 ↔ 418By similarity
Glycosylationi210N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi313 ↔ 327By similarity
Disulfide bondi337 ↔ 360By similarity
Disulfide bondi344 ↔ 353By similarity
Disulfide bondi382 ↔ 388By similarity
Glycosylationi487N-linked (GlcNAc...)Sequence analysis1
Glycosylationi507N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi339724.XP_001536345.1.

Structurei

3D structure databases

ProteinModelPortaliA6RGA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
KOiK13289.
OrthoDBiEOG092C1EU7.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR008442. Propeptide_carboxypepY.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6RGA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSSLALALL VGGAIASGPQ QQVLREPVDH PQAAETPLQK ISDIFGHLSE
60 70 80 90 100
QAGNVWEDVM DKFPDTLMDA ITQTPPPKKH NRRPDSEWDH IVRGSDVQAV
110 120 130 140 150
WVEGDAGEKH RKVGGRLDTY DLRVKAVDPS NLGVDTVKQY SGYLDDNEND
160 170 180 190 200
KHLFYWFFES RNDPKNDPVV LWLNGGPGCS SLTGLFLELG PSSITKQLKV
210 220 230 240 250
EYNEFSWNSN ASVIFLDQPV NVGYSYSSSS VSNTQAAAKD VYALLTLFFE
260 270 280 290 300
QFPEYSRQDF HIAGESYAGH YIPVFASEIM SHSHRNINLK SILVGNGLTD
310 320 330 340 350
PLSQYPHYRP MACGEGGYPA VLSSSSCQAM DNALPRCLAM IQACYNTESR
360 370 380 390 400
WSCVPASIYC NNALIGPYQR SGMNPYDVRS KCEGGSLCYT QLDDISKYLN
410 420 430 440 450
RNAVMESLGA EVSSYESCNM DINRNFLFQG DWMQPYMRVV PTLLAQMPVL
460 470 480 490 500
IYAGDADFIC NWLGNKAWTE ALEYPGHNEF AAAEMKNLTS QNHEDVRVIG
510 520 530 540
QVKSAGNFTF MRLFGGGHMV PMDQPEASLE FFNRWLGGEW SDKSP
Length:545
Mass (Da):60,747
Last modified:August 21, 2007 - v1
Checksum:i4E49F04D1C55BB8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476666 Genomic DNA. Translation: EDN05012.1.
RefSeqiXP_001536345.1. XM_001536295.1.

Genome annotation databases

EnsemblFungiiEDN05012; EDN05012; HCAG_08666.
GeneIDi5442623.
KEGGiaje:HCAG_08666.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476666 Genomic DNA. Translation: EDN05012.1.
RefSeqiXP_001536345.1. XM_001536295.1.

3D structure databases

ProteinModelPortaliA6RGA0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi339724.XP_001536345.1.

Protein family/group databases

MEROPSiS10.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEDN05012; EDN05012; HCAG_08666.
GeneIDi5442623.
KEGGiaje:HCAG_08666.

Organism-specific databases

EuPathDBiFungiDB:HCAG_08666.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
KOiK13289.
OrthoDBiEOG092C1EU7.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR008442. Propeptide_carboxypepY.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBPYA_AJECN
AccessioniPrimary (citable) accession number: A6RGA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: August 21, 2007
Last modified: October 5, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.