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Protein

Glutamate decarboxylase

Gene

HCAG_08662

Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
ORF Names:HCAG_08662Imported
OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)Imported
Taxonomic identifieri339724 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeHistoplasma
ProteomesiUP000009297: Unassembled WGS sequence

PTM / Processingi

Proteomic databases

PRIDEiA6RG96.

Structurei

3D structure databases

ProteinModelPortaliA6RG96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

KOiK01580.
OrthoDBiEOG7P2Z22.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

A6RG96-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVHLAAIRKE SAVLPIRQIQ RIETIPLEEP QEHDFYSSVY GSRFAAEDLP
60 70 80 90 100
TLEMPEKEMP KEVAYRMIRD ELSLDGNPML NLASFVTTYM EEEAEKLMTE
110 120 130 140 150
SFSKNFIDYE EYPQSAEIQN RCVNMIARMF NAPGEDSPEH AMGTSCIGSS
160 170 180 190 200
EAIMLGTLAM KKRWQNKRKA EGKDYSRPNI VMSSAVQVCW EKAARYFEVE
210 220 230 240 250
EKFVYCTTER YVIDPEEAVN LVDENTIGIC AILGTTYTGQ YEDVQAINDL
260 270 280 290 300
LVERGIDCPI HVDAASGGFV APFVNPNLEW DFRLEKVVSI NVSGHKYGLV
310 320 330 340 350
YPGVGWVVWR SPEYLPKELV FNINYLGADQ ASFTLNFSKG ASQVIGQYYQ
360 370 380 390 400
MIRLGKRGYR SIMINLTRTA DYLGAALKEL GFILMSDGRG HGLPLVAFRL
410 420 430 440 450
SSKQGFEFDE FALAHQLRER GWVVPAYTMA PHSEQLKLMR VVVREDFSRS
460 470 480 490 500
RCDLLVADIK LALTHLSEMD RKAMDKYKLH VRQHVSNVGK ATHNPPIYKD
510
DDHSLQGKTG KTHAIC
Length:516
Mass (Da):58,551
Last modified:August 21, 2007 - v1
Checksum:i671531385AEF8860
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476666 Genomic DNA. Translation: EDN05008.1.
RefSeqiXP_001536341.1. XM_001536291.1.

Genome annotation databases

GeneIDi5442735.
KEGGiaje:HCAG_08662.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476666 Genomic DNA. Translation: EDN05008.1.
RefSeqiXP_001536341.1. XM_001536291.1.

3D structure databases

ProteinModelPortaliA6RG96.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA6RG96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5442735.
KEGGiaje:HCAG_08662.

Phylogenomic databases

KOiK01580.
OrthoDBiEOG7P2Z22.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NAm1 / WU24Imported.

Entry informationi

Entry nameiA6RG96_AJECN
AccessioniPrimary (citable) accession number: A6RG96
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: February 4, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.