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A6REI4 (ATG15_AJECN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 8, 2011. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative lipase ATG15
EC=3.1.1.3
Alternative name(s):
Autophagy-related protein 15
Gene names
Name:ATG15
ORF Names:HCAG_08049
OrganismAjellomyces capsulata (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum) [Complete proteome]
Taxonomic identifier339724 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › Ajellomycetaceae › Ajellomyces

Protein attributes

Sequence length585 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May be involved in lysis of subvacuolar cytoplasm to vacuole targeted bodies, intravacuolar autophagic bodies and of intravacuolar multivesicular body (MVB) vesicles By similarity.

Catalytic activity

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity. Golgi apparatus membrane; Single-pass type II membrane protein By similarity. Endosome › multivesicular body membrane; Single-pass type II membrane protein By similarity. Prevacuolar compartment membrane; Single-pass type II membrane protein By similarity. Note: From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC) By similarity.

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Sequence caution

The sequence EDN04383.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 585585Putative lipase ATG15
PRO_0000317957

Regions

Transmembrane1 – 2121Helical; Signal-anchor for type II membrane protein
Topological domain22 – 585564Lumenal By similarity
Compositional bias439 – 575137Thr-rich

Sites

Active site2911Charge relay system By similarity

Amino acid modifications

Glycosylation1711N-linked (GlcNAc...) Potential
Glycosylation1931N-linked (GlcNAc...) Potential
Glycosylation2751N-linked (GlcNAc...) Potential
Glycosylation3401N-linked (GlcNAc...) Potential
Glycosylation4371N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A6REI4 [UniParc].

Last modified February 5, 2008. Version 2.
Checksum: 5EF38668984D7B6B

FASTA58563,488
        10         20         30         40         50         60 
MMGLDLLVSL LALSVSPCIA ATRSPLQIPV LDTQPIETGR EFTLRHMLHH GTYRDPLLHK 

        70         80         90        100        110        120 
RLDIRPDTLL WAASENGEKR ESVPRFRVSS RPINIHRLSD RHVSVVEDYL SIARMTSSAV 

       130        140        150        160        170        180 
TLSSDYWTLD EVDAPDVTDK ETVLSLAKMT SNAYIMIPGS GEWFDVVPPF NHSDSFGWDS 

       190        200        210        220        230        240 
DGLRGHIYSD NTNSTIVVVL KGTSAAIFDG GGTTTNDKVN DNLFFSCCCA QGGHYFWRQV 

       250        260        270        280        290        300 
CDCYSSTYTC NTACVRKALR QENRYYRAAL NLYSNITAMY PQSNIWVTGH SLGGAVSSLL 

       310        320        330        340        350        360 
GMTYGLPVVT FEAVPEALPA SRLGLPPPPG TDPSSPQARN YTGAYHFGHT ADPIYMGTCN 

       370        380        390        400        410        420 
GATSVCTLGG YAMESSCHTG QLCTYDTVED FGWRVGIGTH RIREVITDVI ERYDDVPTCA 

       430        440        450        460        470        480 
PFTECVDCNN WKFFESNETT PTPTTTTTST STRTRTSTCK TPGWWGCLDP TTTPTTTATT 

       490        500        510        520        530        540 
STTSTSTCKT PGWFGCKDPT TTSTVPTASP APTITPTSPP TTTASTTSTC ESPGWFGCND 

       550        560        570        580 
PTSTTTFPVP STTSTSTPCS TPGWFWGCRD QTTTTSASPP ITSPP

« Hide

References

[1]"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives."
Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. expand/collapse author list , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.
Genome Res. 19:1722-1731(2009) [PubMed: 19717792] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NAm1 / WU24.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CH476664 Genomic DNA. Translation: EDN04383.1. Sequence problems.
RefSeqXP_001536940.1. XM_001536890.1.

3D structure databases

ProteinModelPortalA6REI4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5443371.

Family and domain databases

InterProIPR002921. Lipase_3.
[Graphical view]
PfamPF01764. Lipase_3. 1 hit.
[Graphical view]
PROSITEPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATG15_AJECN
AccessionPrimary (citable) accession number: A6REI4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: February 8, 2011
This is version 29 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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