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A6RBI0

- DAPB_AJECN

UniProt

A6RBI0 - DAPB_AJECN

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Protein
Probable dipeptidyl-aminopeptidase B
Gene
DAPB, HCAG_06318
Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei756 – 7561Charge relay system By similarity
Active sitei833 – 8331Charge relay system By similarity
Active sitei866 – 8661Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:DAPB
    ORF Names:HCAG_06318
    OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
    Taxonomic identifieri339724 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
    ProteomesiUP000009297: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles By similarity.

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9999Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei100 – 12021Helical; Signal-anchor for type II membrane protein; Reviewed prediction
    Add
    BLAST
    Topological domaini121 – 922802Vacuolar Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 922922Probable dipeptidyl-aminopeptidase B
    PRO_0000412126Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi135 – 1351N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi200 – 2001N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi351 – 3511N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi574 – 5741N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi815 – 8151N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi902 – 9021N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliA6RBI0.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi64 – 8320Asp-rich
    Add
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S9B family.

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK01282.
    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6RBI0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATEKGHSRD DEERVPLTRG STEFRNSIDS FDYSSSTASL SLAVIDRINN    50
    STQDAGLSEK GPRDDDDDRY WDDDVEYDVE DADYIPSGGK PMHKSVKIAL 100
    WSLLFLSLGG WSLAFVLFIF RSHDTYQTPI LSEDNISSGG LRGDRITLDD 150
    VLGEEWMPRH HFISWFPGPN GEDGLLLEKD GPGSTGYLRV EDIVSRKDTN 200
    SSKGSIVLMQ KNTFTVGGET VICSQVWPSP DLKTVLVLSE KKQNWRHSFT 250
    GKYWLFDVDT QTGQPLDPAA QDQRIQLASW SHKSDAVVFT RDNNMFLRKL 300
    SSKEVITITS DGGVDLLYGV PDWVYEEEVF SGNSATWWAH DGNYIAFLRT 350
    NESAVPEYPI QYFVSRPSGE DPNLGEENYP EVREIKYPKA GAPNPIVDLQ 400
    FYDIRKGEIF SVDVADRFPD DNRLIIEVLW ASNGKVLVRE TNRESDILII 450
    AAIDVLSRTG KIVRKEDINA LDGGWVEPTQ STRFIPADPS NDRPEDGYID 500
    TVIHEGRDQL AYFTPLDNPK PLILTKGHSE VVNSPSGVDL KRGLVYFVVA 550
    GNEPWERHVY SVKFDGTALQ PVTNVSESSY YDVSFSDGAG YALLNFRGPK 600
    VPWQKVISTP ANENPFEEII EQNNHLSRKL RLFSLESKVF QYINIDGFSL 650
    PVLERRPPNF DPTKKYPVLF YLYGGPGSQT VDKKFGVDFQ SYVASTLGYI 700
    VVTVDGRGTG YIGRKSLSLV RGKLGHYEAR DQIEVAKKWA AKPYVDESRM 750
    AIWGWSYGGF MTLKTIEEDG GRTFQYGMAV APVTDWRYYD SIYAERYMHT 800
    PQHNPQGYDS SAISNTTALA NSVRFLVMHG TADDNVHIQN TLTLLDKLDL 850
    ANVDNYDVHV FPDSNHNINY HNAHKMVYTR LADWLVNAFN GQWLKTNNPT 900
    PNDSLFRRVA TWAGLYKFKH LC 922
    Length:922
    Mass (Da):104,147
    Last modified:August 21, 2007 - v1
    Checksum:i34932E3C1D124CDE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476661 Genomic DNA. Translation: EDN10515.1.
    RefSeqiXP_001538713.1. XM_001538663.1.

    Genome annotation databases

    GeneIDi5445066.
    KEGGiaje:HCAG_06318.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476661 Genomic DNA. Translation: EDN10515.1 .
    RefSeqi XP_001538713.1. XM_001538663.1.

    3D structure databases

    ProteinModelPortali A6RBI0.
    ModBasei Search...

    Protein family/group databases

    MEROPSi S09.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5445066.
    KEGGi aje:HCAG_06318.

    Phylogenomic databases

    KOi K01282.
    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NAm1 / WU24.

    Entry informationi

    Entry nameiDAPB_AJECN
    AccessioniPrimary (citable) accession number: A6RBI0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: August 21, 2007
    Last modified: June 11, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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