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Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei756 – 7561Charge relay systemBy similarity
Active sitei833 – 8331Charge relay systemBy similarity
Active sitei866 – 8661Charge relay systemBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:HCAG_06318
OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Taxonomic identifieri339724 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeHistoplasma
ProteomesiUP000009297: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9999CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini121 – 922802VacuolarSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 922922Probable dipeptidyl-aminopeptidase BPRO_0000412126Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi351 – 3511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi574 – 5741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi815 – 8151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi902 – 9021N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliA6RBI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi64 – 8320Asp-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01282.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

A6RBI0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATEKGHSRD DEERVPLTRG STEFRNSIDS FDYSSSTASL SLAVIDRINN
60 70 80 90 100
STQDAGLSEK GPRDDDDDRY WDDDVEYDVE DADYIPSGGK PMHKSVKIAL
110 120 130 140 150
WSLLFLSLGG WSLAFVLFIF RSHDTYQTPI LSEDNISSGG LRGDRITLDD
160 170 180 190 200
VLGEEWMPRH HFISWFPGPN GEDGLLLEKD GPGSTGYLRV EDIVSRKDTN
210 220 230 240 250
SSKGSIVLMQ KNTFTVGGET VICSQVWPSP DLKTVLVLSE KKQNWRHSFT
260 270 280 290 300
GKYWLFDVDT QTGQPLDPAA QDQRIQLASW SHKSDAVVFT RDNNMFLRKL
310 320 330 340 350
SSKEVITITS DGGVDLLYGV PDWVYEEEVF SGNSATWWAH DGNYIAFLRT
360 370 380 390 400
NESAVPEYPI QYFVSRPSGE DPNLGEENYP EVREIKYPKA GAPNPIVDLQ
410 420 430 440 450
FYDIRKGEIF SVDVADRFPD DNRLIIEVLW ASNGKVLVRE TNRESDILII
460 470 480 490 500
AAIDVLSRTG KIVRKEDINA LDGGWVEPTQ STRFIPADPS NDRPEDGYID
510 520 530 540 550
TVIHEGRDQL AYFTPLDNPK PLILTKGHSE VVNSPSGVDL KRGLVYFVVA
560 570 580 590 600
GNEPWERHVY SVKFDGTALQ PVTNVSESSY YDVSFSDGAG YALLNFRGPK
610 620 630 640 650
VPWQKVISTP ANENPFEEII EQNNHLSRKL RLFSLESKVF QYINIDGFSL
660 670 680 690 700
PVLERRPPNF DPTKKYPVLF YLYGGPGSQT VDKKFGVDFQ SYVASTLGYI
710 720 730 740 750
VVTVDGRGTG YIGRKSLSLV RGKLGHYEAR DQIEVAKKWA AKPYVDESRM
760 770 780 790 800
AIWGWSYGGF MTLKTIEEDG GRTFQYGMAV APVTDWRYYD SIYAERYMHT
810 820 830 840 850
PQHNPQGYDS SAISNTTALA NSVRFLVMHG TADDNVHIQN TLTLLDKLDL
860 870 880 890 900
ANVDNYDVHV FPDSNHNINY HNAHKMVYTR LADWLVNAFN GQWLKTNNPT
910 920
PNDSLFRRVA TWAGLYKFKH LC
Length:922
Mass (Da):104,147
Last modified:August 21, 2007 - v1
Checksum:i34932E3C1D124CDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476661 Genomic DNA. Translation: EDN10515.1.
RefSeqiXP_001538713.1. XM_001538663.1.

Genome annotation databases

GeneIDi5445066.
KEGGiaje:HCAG_06318.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476661 Genomic DNA. Translation: EDN10515.1.
RefSeqiXP_001538713.1. XM_001538663.1.

3D structure databases

ProteinModelPortaliA6RBI0.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS09.006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5445066.
KEGGiaje:HCAG_06318.

Phylogenomic databases

KOiK01282.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NAm1 / WU24.

Entry informationi

Entry nameiDAPB_AJECN
AccessioniPrimary (citable) accession number: A6RBI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: August 21, 2007
Last modified: February 4, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.