ID A6R7Z9_AJECN Unreviewed; 1201 AA. AC A6R7Z9; DT 21-AUG-2007, integrated into UniProtKB/TrEMBL. DT 21-AUG-2007, sequence version 1. DT 27-MAR-2024, entry version 98. DE RecName: Full=Cell division control protein {ECO:0008006|Google:ProtNLM}; GN ORFNames=HCAG_06440 {ECO:0000313|EMBL:EDN09273.1}; OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) OS (Histoplasma capsulatum). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma. OX NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN09273.1, ECO:0000313|Proteomes:UP000009297}; RN [1] {ECO:0000313|Proteomes:UP000009297} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297}; RX PubMed=19717792; DOI=10.1101/gr.087551.108; RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T., RA Henn M.R., Birren B.W., Taylor J.W.; RT "Comparative genomic analyses of the human fungal pathogens Coccidioides RT and their relatives."; RL Genome Res. 19:1722-1731(2009). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH476660; EDN09273.1; -; Genomic_DNA. DR AlphaFoldDB; A6R7Z9; -. DR STRING; 339724.A6R7Z9; -. DR VEuPathDB; FungiDB:HCAG_06440; -. DR HOGENOM; CLU_002632_0_0_1; -. DR OMA; DWPGPDS; -. DR OrthoDB; 68574at2759; -. DR Proteomes; UP000009297; Unassembled WGS sequence. DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. DR CDD; cd00155; RasGEF; 1. DR CDD; cd06224; REM; 1. DR CDD; cd11883; SH3_Sdc25; 1. DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1. DR Gene3D; 2.30.30.40; SH3 Domains; 1. DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1. DR InterPro; IPR008937; Ras-like_GEF. DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N. DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS. DR InterPro; IPR023578; Ras_GEF_dom_sf. DR InterPro; IPR001895; RASGEF_cat_dom. DR InterPro; IPR036964; RASGEF_cat_dom_sf. DR InterPro; IPR036028; SH3-like_dom_sf. DR InterPro; IPR001452; SH3_domain. DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1. DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1. DR Pfam; PF00617; RasGEF; 1. DR Pfam; PF00618; RasGEF_N; 1. DR Pfam; PF00018; SH3_1; 1. DR PRINTS; PR00452; SH3DOMAIN. DR SMART; SM00147; RasGEF; 1. DR SMART; SM00229; RasGEFN; 1. DR SMART; SM00326; SH3; 1. DR SUPFAM; SSF48366; Ras GEF; 1. DR SUPFAM; SSF50044; SH3-domain; 1. DR PROSITE; PS00720; RASGEF; 1. DR PROSITE; PS50009; RASGEF_CAT; 1. DR PROSITE; PS50212; RASGEF_NTER; 1. DR PROSITE; PS50002; SH3; 1. PE 4: Predicted; KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658, KW ECO:0000256|PROSITE-ProRule:PRU00168}; KW Reference proteome {ECO:0000313|Proteomes:UP000009297}; KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE- KW ProRule:PRU00192}. FT DOMAIN 70..129 FT /note="SH3" FT /evidence="ECO:0000259|PROSITE:PS50002" FT DOMAIN 771..904 FT /note="N-terminal Ras-GEF" FT /evidence="ECO:0000259|PROSITE:PS50212" FT DOMAIN 940..1176 FT /note="Ras-GEF" FT /evidence="ECO:0000259|PROSITE:PS50009" FT REGION 137..188 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 214..293 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 310..350 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 697..728 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 150..165 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 166..185 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 214..229 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 269..285 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1201 AA; 133821 MW; 42EA3CCDC5E6E530 CRC64; MYSSRSAVPL TVNSKSVLNA KPGTFAAAFH YTEDEALSSN DNSQYHSTNN HSYHADMARH HGNDGYVESP PALYVRALYN YTADDHTSLS FRQGDIIQVL NQLDTGWWDG VMGDVRGWFP SNYCAVVTDP DSIGLGGGHF GHESGDISAE SGADDYDDDD DLDSEGNSKD ERSILPTEGT RGSEHEEAAF WIPQATADGR LFYFNTLTGR STAELPLESP MSATETGPRD RTNIFVPEQT RPPPELMVGG IDRDEDDYDG SGSEAEGESL IRSSHDSESR RRRSFISDGV SPATSLDSIN ASPIVISYSE SKHTHQSPPS SSGQLPSNSG VLSSAANAQP AQNERLSSQS ISSTIPRLFL DDGSSTPLTW NKLVGNMRQA IDAYRRAIME GHREQYVRRA EDISDHLRML LAAGSDTTDN HSGNPSIIST NKALYPHFRD MMSKFSKLVL SSHIAAADWR GPDSDAKCLQ EAEGVLHGVY GYVEVAKQQR GDDISRLVPG FVQGSSSGGH WQNNNVGIRN PTTFLDYENQ DSGLEPTVVL NSNIVYRIEN LKDMLAASTR RLEENLSLSE KTITPRIHLA IADTVCAACS RVVECFQPWM SLVESIDLSP LERGSQNPQL VDYSLQKQRA YDGIADLVLS CQAVSAPLGD EWAEMRGDTL ETRLAGVRSV SRQLQNYVAQ IGFSLTLLLE QAPSEAPPAR DIGGASLSKV PSGSIGMPSA YPPADRQPVK SRANIDKAQR FFGDTIPTEP AMQWYLNIDH ESEVFYDNKG EVPTLKCGTL AGLVEHLTRH DKLDTSFNST FLLTYRSFTT ASELFEMLVH RFTLQPPYGL DKTDLQTWTE QKQIPIRIRV VNIMKNWFEN YWMEPNDDAN MRLLQRVYAF VKDSIGKAKT PGSQQLLSLI DQRMRGQDTS AKRLVPTISG NAPPPILPKN LKKLKFLDID PMEFARQLTI IESRLYARIK PTECLNKTWQ KKLVPDEPDP AANVKALILH SNQLTNWVAE MILHQQDVKR RVVVIKHFVL IAERCRAMNN YSTLTSIISA LGTAPVHRLN RTWAQVSARI LAVLENMRRL MASTKNFGEY REALHLANPP CIPFFGVYLT DLTFIEDGIP SLTQSHLINF NKRAKTAEVI RDIQQYQNAP YPFHPVPELQ DYVLSNMQAA GDVHEMYDRS LEVEPRERED EKIARYGQMN DASVFALMIS T //