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Protein

Glutamate decarboxylase

Gene

HCAG_05038

Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
ORF Names:HCAG_05038Imported
OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)Imported
Taxonomic identifieri339724 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeHistoplasma
ProteomesiUP000009297: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliA6R5Y0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

KOiK01580.
OrthoDBiEOG7P2Z22.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 2 hits.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

A6R5Y0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLAAHVDVN QLIEDLRNDP KRRKSERLWT ENVSGSMTPY STRYASHEEI
60 70 80 90 100
PKFKLPEKGA PAEAVRRMLR DDLDLDGIPN LNLASFVGTY MEREADELLF
110 120 130 140 150
ENISKNLADA DEYPALMEMH AHCVSMISNL WHAQPGEHAI GSATTGSSEA
160 170 180 190 200
ILLGGLAMKK RWQETKKAAG KDTSKPNIIM GANAQVALLK FARYFDVEAR
210 220 230 240 250
ILDVSQKSEY RLDPDLVKKN LDENTIGVFV IMGSTYTGHY EPVEEISNIL
260 270 280 290 300
DEFEAKTGID VPIHVDGASG AFVAPFTYAQ AGGPKWDFAL PRVKSINTSG
310 320 330 340 350
HKFGLVYAGL GWIVWRDRTY LPSDLIFELH YLGGTEETFT LNFSRPGMQV
360 370 380 390 400
VGQYYNFIRL GFNGYREIME NCLANARLLS TALENTGWFL CISGIHRKNG
410 420 430 440 450
SSKVEQTNGL LKYQEGETSA DYNAGLPVVS FRFSDEVQQK YPDVKQESVS
460 470 480 490 500
LLLRAKQYII PNYPLPPAED KTETLRIVVR ESMSADLIDR LVADIVAVTE
510 520 530 540 550
RLMASEPVDV AALQTGPTSI ARRLVSTVLE NKSAISSIGM IFAWNRGGCH
Length:550
Mass (Da):61,231
Last modified:August 21, 2007 - v1
Checksum:iE3EB8D60DCD42B2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476659 Genomic DNA. Translation: EDN08539.1.
RefSeqiXP_001539571.1. XM_001539521.1.

Genome annotation databases

GeneIDi5445909.
KEGGiaje:HCAG_05038.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476659 Genomic DNA. Translation: EDN08539.1.
RefSeqiXP_001539571.1. XM_001539521.1.

3D structure databases

ProteinModelPortaliA6R5Y0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5445909.
KEGGiaje:HCAG_05038.

Phylogenomic databases

KOiK01580.
OrthoDBiEOG7P2Z22.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 2 hits.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NAm1 / WU24Imported.

Entry informationi

Entry nameiA6R5Y0_AJECN
AccessioniPrimary (citable) accession number: A6R5Y0
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: February 4, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.