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A6R4B6

- A6R4B6_AJECN

UniProt

A6R4B6 - A6R4B6_AJECN

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Protein

Histone deacetylase

Gene

HCAG_04474

Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
ORF Names:HCAG_04474Imported
OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)Imported
Taxonomic identifieri339724 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
ProteomesiUP000009297: Unassembled WGS sequence

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA6R4B6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

KOiK11483.
OrthoDBiEOG78M0B2.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

A6R4B6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARSTIVQEY ASPAVAQTSL SLDRKTAREV ENEGFKRPKG YTVSWHANPD
60 70 80 90 100
VEPHHFGSSH PMKPWRLTLT KQIVMAYGMH HAMDLYKTRE ATYEEMAEFH
110 120 130 140 150
SPEYLDFLQT VIPSDMENTA LNDRMAGFNF GDDCPVFDGL YNYCSHYAGG
160 170 180 190 200
TLDAARKLCN NQSEIAINWS GGLHHAKKSE ASGFCYINDI VLGILQLLRL
210 220 230 240 250
HPRVMYIDID VHHGDGVEQA FWSTDRVLTV SFHKYDKDNF FPGTGGLDDT
260 270 280 290 300
GPSNPFNPGA HHALNVPLHD GIEDAEYVSL FKSIIGPCIR TYQPGAIILQ
310 320 330 340 350
CGADSLGCDR LGCFNLNIRA HGACVAYTKT FNLPTLVVGG GGYTPRNVSR
360 370 380 390 400
LWAYETAICI DGATDINPQL PDSLPFRSHF KPDCSLFPPL SDMRRLENRN
410 420 430 440 450
SKAYLESVTQ AVLEQLRYIK GAPSVQMRHI PPDIMGLRED IEKEIEAEKE
460 470 480
MMEAEQEERA GAGSNGGKWS RRKDLEKGLG I
Length:481
Mass (Da):53,691
Last modified:August 21, 2007 - v1
Checksum:i0208EB7D6AAB8727
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476658 Genomic DNA. Translation: EDN07964.1.
RefSeqiXP_001540634.1. XM_001540584.1.

Genome annotation databases

GeneIDi5447223.
KEGGiaje:HCAG_04474.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476658 Genomic DNA. Translation: EDN07964.1 .
RefSeqi XP_001540634.1. XM_001540584.1.

3D structure databases

ProteinModelPortali A6R4B6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5447223.
KEGGi aje:HCAG_04474.

Phylogenomic databases

KOi K11483.
OrthoDBi EOG78M0B2.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
PRINTSi PR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NAm1 / WU24Imported.

Entry informationi

Entry nameiA6R4B6_AJECN
AccessioniPrimary (citable) accession number: A6R4B6
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3