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A6R4B6

- A6R4B6_AJECN

UniProt

A6R4B6 - A6R4B6_AJECN

Protein

Histone deacetylase

Gene

HCAG_04474

Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

    GO - Molecular functioni

    1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
    Gene namesi
    ORF Names:HCAG_04474Imported
    OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)Imported
    Taxonomic identifieri339724 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
    ProteomesiUP000009297: Unassembled WGS sequence

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliA6R4B6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    KOiK11483.
    OrthoDBiEOG78M0B2.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSiPR01270. HDASUPER.
    PR01271. HISDACETLASE.

    Sequencei

    Sequence statusi: Complete.

    A6R4B6-1 [UniParc]FASTAAdd to Basket

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    MARSTIVQEY ASPAVAQTSL SLDRKTAREV ENEGFKRPKG YTVSWHANPD    50
    VEPHHFGSSH PMKPWRLTLT KQIVMAYGMH HAMDLYKTRE ATYEEMAEFH 100
    SPEYLDFLQT VIPSDMENTA LNDRMAGFNF GDDCPVFDGL YNYCSHYAGG 150
    TLDAARKLCN NQSEIAINWS GGLHHAKKSE ASGFCYINDI VLGILQLLRL 200
    HPRVMYIDID VHHGDGVEQA FWSTDRVLTV SFHKYDKDNF FPGTGGLDDT 250
    GPSNPFNPGA HHALNVPLHD GIEDAEYVSL FKSIIGPCIR TYQPGAIILQ 300
    CGADSLGCDR LGCFNLNIRA HGACVAYTKT FNLPTLVVGG GGYTPRNVSR 350
    LWAYETAICI DGATDINPQL PDSLPFRSHF KPDCSLFPPL SDMRRLENRN 400
    SKAYLESVTQ AVLEQLRYIK GAPSVQMRHI PPDIMGLRED IEKEIEAEKE 450
    MMEAEQEERA GAGSNGGKWS RRKDLEKGLG I 481
    Length:481
    Mass (Da):53,691
    Last modified:August 21, 2007 - v1
    Checksum:i0208EB7D6AAB8727
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476658 Genomic DNA. Translation: EDN07964.1.
    RefSeqiXP_001540634.1. XM_001540584.1.

    Genome annotation databases

    GeneIDi5447223.
    KEGGiaje:HCAG_04474.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476658 Genomic DNA. Translation: EDN07964.1 .
    RefSeqi XP_001540634.1. XM_001540584.1.

    3D structure databases

    ProteinModelPortali A6R4B6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5447223.
    KEGGi aje:HCAG_04474.

    Phylogenomic databases

    KOi K11483.
    OrthoDBi EOG78M0B2.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSi PR01270. HDASUPER.
    PR01271. HISDACETLASE.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NAm1 / WU24Imported.

    Entry informationi

    Entry nameiA6R4B6_AJECN
    AccessioniPrimary (citable) accession number: A6R4B6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 21, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3