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Protein

Histone deacetylase

Gene

HCAG_04474

Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
ORF Names:HCAG_04474Imported
OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)Imported
Taxonomic identifieri339724 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeHistoplasma
ProteomesiUP000009297 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:HCAG_04474.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi339724.XP_001540634.1.

Structurei

3D structure databases

ProteinModelPortaliA6R4B6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

KOiK11483.
OrthoDBiEOG78M0B2.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

A6R4B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARSTIVQEY ASPAVAQTSL SLDRKTAREV ENEGFKRPKG YTVSWHANPD
60 70 80 90 100
VEPHHFGSSH PMKPWRLTLT KQIVMAYGMH HAMDLYKTRE ATYEEMAEFH
110 120 130 140 150
SPEYLDFLQT VIPSDMENTA LNDRMAGFNF GDDCPVFDGL YNYCSHYAGG
160 170 180 190 200
TLDAARKLCN NQSEIAINWS GGLHHAKKSE ASGFCYINDI VLGILQLLRL
210 220 230 240 250
HPRVMYIDID VHHGDGVEQA FWSTDRVLTV SFHKYDKDNF FPGTGGLDDT
260 270 280 290 300
GPSNPFNPGA HHALNVPLHD GIEDAEYVSL FKSIIGPCIR TYQPGAIILQ
310 320 330 340 350
CGADSLGCDR LGCFNLNIRA HGACVAYTKT FNLPTLVVGG GGYTPRNVSR
360 370 380 390 400
LWAYETAICI DGATDINPQL PDSLPFRSHF KPDCSLFPPL SDMRRLENRN
410 420 430 440 450
SKAYLESVTQ AVLEQLRYIK GAPSVQMRHI PPDIMGLRED IEKEIEAEKE
460 470 480
MMEAEQEERA GAGSNGGKWS RRKDLEKGLG I
Length:481
Mass (Da):53,691
Last modified:August 21, 2007 - v1
Checksum:i0208EB7D6AAB8727
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476658 Genomic DNA. Translation: EDN07964.1.
RefSeqiXP_001540634.1. XM_001540584.1.

Genome annotation databases

GeneIDi5447223.
KEGGiaje:HCAG_04474.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476658 Genomic DNA. Translation: EDN07964.1.
RefSeqiXP_001540634.1. XM_001540584.1.

3D structure databases

ProteinModelPortaliA6R4B6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi339724.XP_001540634.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5447223.
KEGGiaje:HCAG_04474.

Organism-specific databases

EuPathDBiFungiDB:HCAG_04474.

Phylogenomic databases

KOiK11483.
OrthoDBiEOG78M0B2.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NAm1 / WU24Imported.

Entry informationi

Entry nameiA6R4B6_AJECN
AccessioniPrimary (citable) accession number: A6R4B6
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: July 22, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.