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A6R400

- A6R400_AJECN

UniProt

A6R400 - A6R400_AJECN

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Protein

Isocitrate dehydrogenase [NADP]

Gene

HCAG_04358

Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei66 – 661SubstrateUniRule annotation
Binding sitei98 – 981SubstrateUniRule annotation
Binding sitei121 – 1211SubstrateUniRule annotation
Sitei128 – 1281Critical for catalysisUniRule annotation
Sitei199 – 1991Critical for catalysisUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:HCAG_04358Imported
OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)Imported
Taxonomic identifieri339724 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
ProteomesiUP000009297: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliA6R400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni83 – 897Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.
OrthoDBiEOG7G4QQD.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 2 hits.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

A6R400-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTGSRRKIKV KNPVVELDGD EMTRIIWQDI KDKGLEYRDQ TNDQVTIDSA
60 70 80 90 100
EAIKKYGVGV KCATITPDEA RVEEFKLKQM WLSPNGTIRN ILGGTVFREP
110 120 130 140 150
IVIPRIPRLV PGWKKPIIIG RHAFGDQYRA KDLVVPGPGT LELVYTPKGG
160 170 180 190 200
QPEHIKVFDF EGGGVAMSQY NTDDSIAGFA HASFKLALLK EMPLYMSTKN
210 220 230 240 250
TILKKYDGRF KDIFQEIFEA NYKKDFDAKG IWYEHRLIDD MVAQMIKSDG
260 270 280 290 300
GFVIAMKTAH GTVTRHYREY QKGNETSTNP IASIFAWTRG LIRRGQLDNT
310 320 330 340 350
PDVVVWAEQL ERACIDVVDE DGVMTKDLAL ACGRKDRAAW VTTREYLEAV
360
ERRLQKNLAN AKL
Length:363
Mass (Da):41,159
Last modified:August 21, 2007 - v1
Checksum:iD25A8C9FC6A06D0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476658 Genomic DNA. Translation: EDN07848.1.
RefSeqiXP_001540518.1. XM_001540468.1.

Genome annotation databases

GeneIDi5447074.
KEGGiaje:HCAG_04358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476658 Genomic DNA. Translation: EDN07848.1 .
RefSeqi XP_001540518.1. XM_001540468.1.

3D structure databases

ProteinModelPortali A6R400.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5447074.
KEGGi aje:HCAG_04358.

Phylogenomic databases

KOi K00031.
OrthoDBi EOG7G4QQD.

Family and domain databases

Gene3Di 3.40.718.10. 2 hits.
InterProi IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 2 hits.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NAm1 / WU24Imported.

Entry informationi

Entry nameiA6R400_AJECN
AccessioniPrimary (citable) accession number: A6R400
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: November 26, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3