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Protein
Submitted name:

Putative uncharacterized protein

Gene

HCAG_04358

Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei66 – 661SubstrateUniRule annotation
Binding sitei98 – 981SubstrateUniRule annotation
Binding sitei121 – 1211SubstrateUniRule annotation
Sitei128 – 1281Critical for catalysisUniRule annotation
Sitei199 – 1991Critical for catalysisUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
ORF Names:HCAG_04358Imported
OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)Imported
Taxonomic identifieri339724 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeHistoplasma
ProteomesiUP000009297 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliA6R400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni83 – 897Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.
OrthoDBiEOG7G4QQD.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

A6R400-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGSRRKIKV KNPVVELDGD EMTRIIWQDI KDKGLEYRDQ TNDQVTIDSA
60 70 80 90 100
EAIKKYGVGV KCATITPDEA RVEEFKLKQM WLSPNGTIRN ILGGTVFREP
110 120 130 140 150
IVIPRIPRLV PGWKKPIIIG RHAFGDQYRA KDLVVPGPGT LELVYTPKGG
160 170 180 190 200
QPEHIKVFDF EGGGVAMSQY NTDDSIAGFA HASFKLALLK EMPLYMSTKN
210 220 230 240 250
TILKKYDGRF KDIFQEIFEA NYKKDFDAKG IWYEHRLIDD MVAQMIKSDG
260 270 280 290 300
GFVIAMKTAH GTVTRHYREY QKGNETSTNP IASIFAWTRG LIRRGQLDNT
310 320 330 340 350
PDVVVWAEQL ERACIDVVDE DGVMTKDLAL ACGRKDRAAW VTTREYLEAV
360
ERRLQKNLAN AKL
Length:363
Mass (Da):41,159
Last modified:August 20, 2007 - v1
Checksum:iD25A8C9FC6A06D0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476658 Genomic DNA. Translation: EDN07848.1.
RefSeqiXP_001540518.1. XM_001540468.1.

Genome annotation databases

GeneIDi5447074.
KEGGiaje:HCAG_04358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476658 Genomic DNA. Translation: EDN07848.1.
RefSeqiXP_001540518.1. XM_001540468.1.

3D structure databases

ProteinModelPortaliA6R400.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5447074.
KEGGiaje:HCAG_04358.

Phylogenomic databases

KOiK00031.
OrthoDBiEOG7G4QQD.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NAm1 / WU24Imported.

Entry informationi

Entry nameiA6R400_AJECN
AccessioniPrimary (citable) accession number: A6R400
Entry historyi
Integrated into UniProtKB/TrEMBL: August 20, 2007
Last sequence update: August 20, 2007
Last modified: March 31, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.