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A6R400 (A6R400_AJECN) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443 PIRNR PIRNR000108

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding64 – 663NADP By similarity
Nucleotide binding261 – 2666NADP By similarity
Region83 – 897Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Binding site661Substrate By similarity PIRSR PIRSR000108-2
Binding site711NADP By similarity
Binding site981Substrate By similarity PIRSR PIRSR000108-2
Binding site1211Substrate By similarity PIRSR PIRSR000108-2
Binding site2471NADP By similarity
Binding site2791NADP; via amide nitrogen and carbonyl oxygen By similarity
Site1281Critical for catalysis By similarity PIRSR PIRSR000108-1
Site1991Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
A6R400 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: D25A8C9FC6A06D0D

FASTA36341,159
        10         20         30         40         50         60 
MTGSRRKIKV KNPVVELDGD EMTRIIWQDI KDKGLEYRDQ TNDQVTIDSA EAIKKYGVGV 

        70         80         90        100        110        120 
KCATITPDEA RVEEFKLKQM WLSPNGTIRN ILGGTVFREP IVIPRIPRLV PGWKKPIIIG 

       130        140        150        160        170        180 
RHAFGDQYRA KDLVVPGPGT LELVYTPKGG QPEHIKVFDF EGGGVAMSQY NTDDSIAGFA 

       190        200        210        220        230        240 
HASFKLALLK EMPLYMSTKN TILKKYDGRF KDIFQEIFEA NYKKDFDAKG IWYEHRLIDD 

       250        260        270        280        290        300 
MVAQMIKSDG GFVIAMKTAH GTVTRHYREY QKGNETSTNP IASIFAWTRG LIRRGQLDNT 

       310        320        330        340        350        360 
PDVVVWAEQL ERACIDVVDE DGVMTKDLAL ACGRKDRAAW VTTREYLEAV ERRLQKNLAN 


AKL 

« Hide

References

[1]"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives."
Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. expand/collapse author list , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.
Genome Res. 19:1722-1731(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NAm1 / WU24.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476658 Genomic DNA. Translation: EDN07848.1.
RefSeqXP_001540518.1. XM_001540468.1.

3D structure databases

ProteinModelPortalA6R400.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5447074.
KEGGaje:HCAG_04358.

Phylogenomic databases

KOK00031.
OrthoDBEOG7G4QQD.

Family and domain databases

Gene3D3.40.718.10. 2 hits.
InterProIPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 2 hits.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA6R400_AJECN
AccessionPrimary (citable) accession number: A6R400
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: July 9, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)