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A6R400

- A6R400_AJECN

UniProt

A6R400 - A6R400_AJECN

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Protein
Isocitrate dehydrogenase [NADP]
Gene
HCAG_04358
Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei66 – 661Substrate By similarityUniRule annotation
Binding sitei71 – 711NADP By similarity
Binding sitei98 – 981Substrate By similarityUniRule annotation
Binding sitei121 – 1211Substrate By similarityUniRule annotation
Sitei128 – 1281Critical for catalysis By similarityUniRule annotation
Sitei199 – 1991Critical for catalysis By similarityUniRule annotation
Binding sitei247 – 2471NADP By similarity
Binding sitei279 – 2791NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 663NADP By similarity
Nucleotide bindingi261 – 2666NADP By similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:HCAG_04358Imported
OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)Imported
Taxonomic identifieri339724 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
ProteomesiUP000009297: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliA6R400.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni83 – 897Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00031.
OrthoDBiEOG7G4QQD.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 2 hits.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

A6R400-1 [UniParc]FASTAAdd to Basket

« Hide

MTGSRRKIKV KNPVVELDGD EMTRIIWQDI KDKGLEYRDQ TNDQVTIDSA    50
EAIKKYGVGV KCATITPDEA RVEEFKLKQM WLSPNGTIRN ILGGTVFREP 100
IVIPRIPRLV PGWKKPIIIG RHAFGDQYRA KDLVVPGPGT LELVYTPKGG 150
QPEHIKVFDF EGGGVAMSQY NTDDSIAGFA HASFKLALLK EMPLYMSTKN 200
TILKKYDGRF KDIFQEIFEA NYKKDFDAKG IWYEHRLIDD MVAQMIKSDG 250
GFVIAMKTAH GTVTRHYREY QKGNETSTNP IASIFAWTRG LIRRGQLDNT 300
PDVVVWAEQL ERACIDVVDE DGVMTKDLAL ACGRKDRAAW VTTREYLEAV 350
ERRLQKNLAN AKL 363
Length:363
Mass (Da):41,159
Last modified:August 21, 2007 - v1
Checksum:iD25A8C9FC6A06D0D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476658 Genomic DNA. Translation: EDN07848.1.
RefSeqiXP_001540518.1. XM_001540468.1.

Genome annotation databases

GeneIDi5447074.
KEGGiaje:HCAG_04358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476658 Genomic DNA. Translation: EDN07848.1 .
RefSeqi XP_001540518.1. XM_001540468.1.

3D structure databases

ProteinModelPortali A6R400.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5447074.
KEGGi aje:HCAG_04358.

Phylogenomic databases

KOi K00031.
OrthoDBi EOG7G4QQD.

Family and domain databases

Gene3Di 3.40.718.10. 2 hits.
InterProi IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 2 hits.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NAm1 / WU24.

Entry informationi

Entry nameiA6R400_AJECN
AccessioniPrimary (citable) accession number: A6R400
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: July 9, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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