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A6R400

- A6R400_AJECN

UniProt

A6R400 - A6R400_AJECN

Protein

Isocitrate dehydrogenase [NADP]

Gene

HCAG_04358

Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei66 – 661SubstrateUniRule annotation
    Binding sitei71 – 711NADP
    Binding sitei98 – 981SubstrateUniRule annotation
    Binding sitei121 – 1211SubstrateUniRule annotation
    Sitei128 – 1281Critical for catalysisUniRule annotation
    Sitei199 – 1991Critical for catalysisUniRule annotation
    Binding sitei247 – 2471NADP
    Binding sitei279 – 2791NADP; via amide nitrogen and carbonyl oxygen

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi64 – 663NADP
    Nucleotide bindingi261 – 2666NADP

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    ORF Names:HCAG_04358Imported
    OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)Imported
    Taxonomic identifieri339724 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
    ProteomesiUP000009297: Unassembled WGS sequence

    Structurei

    3D structure databases

    ProteinModelPortaliA6R400.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni83 – 897Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.
    OrthoDBiEOG7G4QQD.

    Family and domain databases

    Gene3Di3.40.718.10. 2 hits.
    InterProiIPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6R400-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGSRRKIKV KNPVVELDGD EMTRIIWQDI KDKGLEYRDQ TNDQVTIDSA    50
    EAIKKYGVGV KCATITPDEA RVEEFKLKQM WLSPNGTIRN ILGGTVFREP 100
    IVIPRIPRLV PGWKKPIIIG RHAFGDQYRA KDLVVPGPGT LELVYTPKGG 150
    QPEHIKVFDF EGGGVAMSQY NTDDSIAGFA HASFKLALLK EMPLYMSTKN 200
    TILKKYDGRF KDIFQEIFEA NYKKDFDAKG IWYEHRLIDD MVAQMIKSDG 250
    GFVIAMKTAH GTVTRHYREY QKGNETSTNP IASIFAWTRG LIRRGQLDNT 300
    PDVVVWAEQL ERACIDVVDE DGVMTKDLAL ACGRKDRAAW VTTREYLEAV 350
    ERRLQKNLAN AKL 363
    Length:363
    Mass (Da):41,159
    Last modified:August 21, 2007 - v1
    Checksum:iD25A8C9FC6A06D0D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476658 Genomic DNA. Translation: EDN07848.1.
    RefSeqiXP_001540518.1. XM_001540468.1.

    Genome annotation databases

    GeneIDi5447074.
    KEGGiaje:HCAG_04358.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476658 Genomic DNA. Translation: EDN07848.1 .
    RefSeqi XP_001540518.1. XM_001540468.1.

    3D structure databases

    ProteinModelPortali A6R400.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5447074.
    KEGGi aje:HCAG_04358.

    Phylogenomic databases

    KOi K00031.
    OrthoDBi EOG7G4QQD.

    Family and domain databases

    Gene3Di 3.40.718.10. 2 hits.
    InterProi IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NAm1 / WU24Imported.

    Entry informationi

    Entry nameiA6R400_AJECN
    AccessioniPrimary (citable) accession number: A6R400
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 21, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3