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A6R213 (ACUK_AJECN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription activator of gluconeogenesis HCAG_03671
Gene names
ORF Names:HCAG_03671
OrganismAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum) [Complete proteome]
Taxonomic identifier339724 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces

Protein attributes

Sequence length776 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the ERT1/acuK family.

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.

Ontologies

Keywords
   Biological processGluconeogenesis
Transcription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding RNA polymerase II transcription factor activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 776776Transcription activator of gluconeogenesis HCAG_03671
PRO_0000406425

Regions

DNA binding77 – 10529Zn(2)-C6 fungal-type
Compositional bias660 – 6689Poly-Gly

Sequences

Sequence LengthMass (Da)Tools
A6R213 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 96B29880BC6DE8AA

FASTA77682,947
        10         20         30         40         50         60 
MTASTQNGSP TPPPAAPTAT NQESKNMTAN PADASESQSP ANEKGGGTAE NGQKHTSTAA 

        70         80         90        100        110        120 
NAKDPLRPRR KKAKRACFAC QRAHLTCGDE RPCQRCIKRG LQDACHDGVR KKAKYLHDAP 

       130        140        150        160        170        180 
NEALMPGIRR NFYNQANATR TNASQQQNGP NSNSNKDSRQ NVAANFYSPQ SASNFDVYTQ 

       190        200        210        220        230        240 
AKSQQGQGHI PPTVMQDTSI NPSAFQAPSP TSTPNFDLSS NPPNRNLSSA MTQTPSSASN 

       250        260        270        280        290        300 
QTQDPFGAAF FDPSHPALFN FDIASMNFGN RYGALEFGML GHMATGAGDT PPSDSATQRG 

       310        320        330        340        350        360 
SIGRSSGTFT AQNFGDSTNT QPPFLFGDPV LNDWNPSGQS QTNPRNNNIY NQNTVAGQMG 

       370        380        390        400        410        420 
EQHPNAFAIE SAPMNFASPG STESPQMTTM NQFDEANAKF SSRTALMHQT NPHQPPPIST 

       430        440        450        460        470        480 
PGLKHQGFQV GVKRRYRSPS SIYESVKEPY SYTSGFHNLT AFIQRRFSPQ KTLQIAKALA 

       490        500        510        520        530        540 
SIRPSFIATT KTLNQDDLIF MEKCFQRTLW EYEDFINACG TPTIVCRRTG EIAAVGKEFS 

       550        560        570        580        590        600 
ILTGWKKEVL LGKEPNLNVN TGGSSPRGSG TFTPRNGNGV DPHSGMSASG GGGGRTQPVF 

       610        620        630        640        650        660 
LAELLDDDSV IEFYEDFAKL AFGDSRGSVM TTCKLLKYKT KEDSAALFQG REAQQGGPDG 

       670        680        690        700        710        720 
KGGGGGGGDV ATTAATTSTS TSNGANSSGH ANANRNNTNP NNSSPPSSSS AAAAGPLHGA 

       730        740        750        760        770 
QLSPKQTWGK RGIAGEAGMN QLGFRDGKVE CSYCWTVKRD VFDIPMLIVM NFLPCI 

« Hide

References

[1]"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives."
Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. expand/collapse author list , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.
Genome Res. 19:1722-1731(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NAm1 / WU24.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476657 Genomic DNA. Translation: EDN07140.1.
RefSeqXP_001541573.1. XM_001541523.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5447923.
KEGGaje:HCAG_03671.

Phylogenomic databases

OrthoDBEOG70KGZB.

Family and domain databases

Gene3D4.10.240.10. 1 hit.
InterProIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
SMARTSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMSSF57701. SSF57701. 1 hit.
PROSITEPS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACUK_AJECN
AccessionPrimary (citable) accession number: A6R213
Entry history
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: August 21, 2007
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families