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Protein

Transcription activator of gluconeogenesis HCAG_03671

Gene

HCAG_03671

Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi77 – 10529Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Gluconeogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription activator of gluconeogenesis HCAG_03671
Gene namesi
ORF Names:HCAG_03671
OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Taxonomic identifieri339724 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeHistoplasma
ProteomesiUP000009297 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:HCAG_03671.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 776776Transcription activator of gluconeogenesis HCAG_03671PRO_0000406425Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi339724.XP_001541573.1.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi660 – 6689Poly-Gly

Sequence similaritiesi

Belongs to the ERT1/acuK family.Curated
Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

OrthoDBiEOG70KGZB.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6R213-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTASTQNGSP TPPPAAPTAT NQESKNMTAN PADASESQSP ANEKGGGTAE
60 70 80 90 100
NGQKHTSTAA NAKDPLRPRR KKAKRACFAC QRAHLTCGDE RPCQRCIKRG
110 120 130 140 150
LQDACHDGVR KKAKYLHDAP NEALMPGIRR NFYNQANATR TNASQQQNGP
160 170 180 190 200
NSNSNKDSRQ NVAANFYSPQ SASNFDVYTQ AKSQQGQGHI PPTVMQDTSI
210 220 230 240 250
NPSAFQAPSP TSTPNFDLSS NPPNRNLSSA MTQTPSSASN QTQDPFGAAF
260 270 280 290 300
FDPSHPALFN FDIASMNFGN RYGALEFGML GHMATGAGDT PPSDSATQRG
310 320 330 340 350
SIGRSSGTFT AQNFGDSTNT QPPFLFGDPV LNDWNPSGQS QTNPRNNNIY
360 370 380 390 400
NQNTVAGQMG EQHPNAFAIE SAPMNFASPG STESPQMTTM NQFDEANAKF
410 420 430 440 450
SSRTALMHQT NPHQPPPIST PGLKHQGFQV GVKRRYRSPS SIYESVKEPY
460 470 480 490 500
SYTSGFHNLT AFIQRRFSPQ KTLQIAKALA SIRPSFIATT KTLNQDDLIF
510 520 530 540 550
MEKCFQRTLW EYEDFINACG TPTIVCRRTG EIAAVGKEFS ILTGWKKEVL
560 570 580 590 600
LGKEPNLNVN TGGSSPRGSG TFTPRNGNGV DPHSGMSASG GGGGRTQPVF
610 620 630 640 650
LAELLDDDSV IEFYEDFAKL AFGDSRGSVM TTCKLLKYKT KEDSAALFQG
660 670 680 690 700
REAQQGGPDG KGGGGGGGDV ATTAATTSTS TSNGANSSGH ANANRNNTNP
710 720 730 740 750
NNSSPPSSSS AAAAGPLHGA QLSPKQTWGK RGIAGEAGMN QLGFRDGKVE
760 770
CSYCWTVKRD VFDIPMLIVM NFLPCI
Length:776
Mass (Da):82,947
Last modified:August 21, 2007 - v1
Checksum:i96B29880BC6DE8AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476657 Genomic DNA. Translation: EDN07140.1.
RefSeqiXP_001541573.1. XM_001541523.1.

Genome annotation databases

GeneIDi5447923.
KEGGiaje:HCAG_03671.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476657 Genomic DNA. Translation: EDN07140.1.
RefSeqiXP_001541573.1. XM_001541523.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi339724.XP_001541573.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5447923.
KEGGiaje:HCAG_03671.

Organism-specific databases

EuPathDBiFungiDB:HCAG_03671.

Phylogenomic databases

OrthoDBiEOG70KGZB.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NAm1 / WU24.

Entry informationi

Entry nameiACUK_AJECN
AccessioniPrimary (citable) accession number: A6R213
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: August 21, 2007
Last modified: July 22, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.