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Protein

DNA ligase

Gene

HCAG_02627

Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:HCAG_02627Imported
OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)Imported
Taxonomic identifieri339724 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeHistoplasma
ProteomesiUP000009297: Unassembled WGS sequence

PTM / Processingi

Proteomic databases

PRIDEiA6QZ20.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10777.
OrthoDBiEOG7QC84G.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6QZ20-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSDGEGEPN GSRQQDSTAN DLDEKYPNPP RNHSPTLPFH DLFLTLFNPL
60 70 80 90 100
NENKKRPTGP AAARRKVGPH GQGAAVHLSP QERRRDIIQR FISRWRKEVG
110 120 130 140 150
DDIFPAFRLI IPEKDRDRAM YGLKEKAIGK LLVKVMKIDK NSEDGFSLLN
160 170 180 190 200
WKVPGQSFAS RMAGDFAGRC FEVISKRPLR TEVGDMTIDE VNEQLDKLSA
210 220 230 240 250
ASKEDEQVPI LAYFYRRMNP EELMWLIRII LRQMKVGATE RTFFSIWHPD
260 270 280 290 300
AEALFSISSS LRRVCWQLYN TDVRLEGDET KVTLMQCFQP QLAQFQMQSF
310 320 330 340 350
EHMIRRMRLT EDDPTFWIEE KLDGERIQLH MKPDDSIPGG KRFGFWSRKA
360 370 380 390 400
KEYTYLYGNG LLDENGALTR HLQDAFADGV QSIILDGEMI TWDPEHDAIV
410 420 430 440 450
PFGTLKTAAL AEQRNPFSTG QRPLFRIFDI LYLNGRPLTR YTLKDRRKAL
460 470 480 490 500
EASVIPVHRR FEIHTYDIGH SATDIDPLLR KVVAEASEGL VLKNPNSPYR
510 520 530 540 550
LNERHDDWMK VKPEYMTDFG ESLDCIVIGG YYGSGRRGGA LSSFLCGLRV
560 570 580 590 600
DGSHSKTGDH PTKCYSFCKV GGGFTAADYA NIRHHTDGKW MDWDPKRPPT
610 620 630 640 650
EYIELAGGDL QYERPDVWIK PEDSVVLCVK ASSVTSTDQF RLGLTVRFPR
660 670 680 690 700
FKRLRMDKDW RSALSIQEFM DLKSNVEREV KEKEFKVDDS RKVRHRKAIK
710 720 730 740 750
KPLTIAGYDG GKKLEYVGPS GTLFDGLNFF IMTESVHQPK KTKAQLEQLV
760 770 780 790 800
KANGGKIYQT NNVAENTICI ADRTDQEEEI AEHVDKYSDS YARDIDASEL
810 820 830 840 850
KKLLDSMHPA PALPPSSLSE LESQLESHSL NERKPATPTI SNTSTCPGWL
860 870 880 890 900
FKGLVIYFAM PPSLSNEGNG KIPHVLPQRL YLASNLVKFA GGEVITDDDG
910 920 930 940 950
DMKDARITHV VVDSNPPGDK AAMAAADVAG IRRAISSRAG VGKRIPHIVG
960 970
VEWVEESWGE RTLVDEERFT PK
Length:972
Mass (Da):110,245
Last modified:August 21, 2007 - v1
Checksum:i75EE296AB02C7DA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476656 Genomic DNA. Translation: EDN06024.1.
RefSeqiXP_001542456.1. XM_001542406.1.

Genome annotation databases

GeneIDi5448693.
KEGGiaje:HCAG_02627.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476656 Genomic DNA. Translation: EDN06024.1.
RefSeqiXP_001542456.1. XM_001542406.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA6QZ20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5448693.
KEGGiaje:HCAG_02627.

Phylogenomic databases

KOiK10777.
OrthoDBiEOG7QC84G.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NAm1 / WU24Imported.

Entry informationi

Entry nameiA6QZ20_AJECN
AccessioniPrimary (citable) accession number: A6QZ20
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: February 4, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.