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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

HCAG_02616

Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei384 – 3841S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

  1. histone methyltransferase activity (H3-K79 specific) Source: InterPro

GO - Biological processi

  1. chromatin silencing at telomere Source: InterPro
  2. DNA damage checkpoint Source: InterPro
  3. DNA repair Source: InterPro
  4. regulation of cell cycle Source: InterPro
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
ORF Names:HCAG_02616Imported
OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)Imported
Taxonomic identifieri339724 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeHistoplasma
ProteomesiUP000009297: Unassembled WGS sequence

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni335 – 3384S-adenosyl-L-methionine bindingUniRule annotation
Regioni358 – 36710S-adenosyl-L-methionine bindingUniRule annotation
Regioni420 – 4212S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation

Phylogenomic databases

KOiK11427.
OrthoDBiEOG7KH9VN.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR021162. Dot1.
IPR025789. DOT1_dom.
IPR013110. DOT1_dom_Pfam.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6QZ09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFFDHLQTK GSIAIQPKRP QIRRVETATK PAQPTTSRAA PVASECSGPK
60 70 80 90 100
PAPHSHQRRN RNPNPPTSSR RSSSSARASS TASDPTPSRH HDPAPRLKAR
110 120 130 140 150
SLTRKRPSLI QRLTSSSDES DTEASFLEIR KRMKVSTSAE PDLQRQVRST
160 170 180 190 200
VAFAEDAGKQ TIPIVHASDI ASMDKPAEFS RAFGDGSGSV SVEPFMVRLQ
210 220 230 240 250
YPGISQGENY QLVIPREKEG FKPLDDIVHV VSIVSQHYIP EEHVHLFNDE
260 270 280 290 300
TTGINRRFRR ALAHASESEF TAVVEEYNKI INRLRTDGII AKHLDNIHSL
310 320 330 340 350
PLPLVERILT QTYSRTVSPR VESLRQYENG TDNVYGELLP RFISDIFKQT
360 370 380 390 400
KLKSDQVFVD LGSGVGNVVL QAALEIGCES WGCEVMQNAC DVAELQGREF
410 420 430 440 450
EARCRLWGLS PGIVRLIRGS FLTEESIIRA LHRADVVLIN NQAFTPQLNN
460 470 480 490 500
EIINHFLDMK EGCQIVSLKS FVPAGHRIQA RNLNSPVNLL SVKQKNYWSG

SFEA
Length:504
Mass (Da):56,224
Last modified:August 21, 2007 - v1
Checksum:i62995B72D0105CB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476656 Genomic DNA. Translation: EDN06013.1.
RefSeqiXP_001542445.1. XM_001542395.1.

Genome annotation databases

GeneIDi5449222.
KEGGiaje:HCAG_02616.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476656 Genomic DNA. Translation: EDN06013.1.
RefSeqiXP_001542445.1. XM_001542395.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5449222.
KEGGiaje:HCAG_02616.

Phylogenomic databases

KOiK11427.
OrthoDBiEOG7KH9VN.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR021162. Dot1.
IPR025789. DOT1_dom.
IPR013110. DOT1_dom_Pfam.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NAm1 / WU24Imported.

Entry informationi

Entry nameiA6QZ09_AJECN
AccessioniPrimary (citable) accession number: A6QZ09
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: March 4, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.