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A6QZ09

- A6QZ09_AJECN

UniProt

A6QZ09 - A6QZ09_AJECN

Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

HCAG_02616

Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei384 – 3841S-adenosyl-L-methionineUniRule annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    Histone H3-K79 methyltransferaseUniRule annotation
    Gene namesi
    ORF Names:HCAG_02616Imported
    OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)Imported
    Taxonomic identifieri339724 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
    ProteomesiUP000009297: Unassembled WGS sequence

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliA6QZ09.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni335 – 3384S-adenosyl-L-methionine bindingUniRule annotation
    Regioni358 – 36710S-adenosyl-L-methionine bindingUniRule annotation
    Regioni420 – 4212S-adenosyl-L-methionine bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation

    Phylogenomic databases

    KOiK11427.
    OrthoDBiEOG7KH9VN.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021162. Histone_H3-K79_MeTrfase_fungi.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF08123. DOT1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51569. DOT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6QZ09-1 [UniParc]FASTAAdd to Basket

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    MGFFDHLQTK GSIAIQPKRP QIRRVETATK PAQPTTSRAA PVASECSGPK    50
    PAPHSHQRRN RNPNPPTSSR RSSSSARASS TASDPTPSRH HDPAPRLKAR 100
    SLTRKRPSLI QRLTSSSDES DTEASFLEIR KRMKVSTSAE PDLQRQVRST 150
    VAFAEDAGKQ TIPIVHASDI ASMDKPAEFS RAFGDGSGSV SVEPFMVRLQ 200
    YPGISQGENY QLVIPREKEG FKPLDDIVHV VSIVSQHYIP EEHVHLFNDE 250
    TTGINRRFRR ALAHASESEF TAVVEEYNKI INRLRTDGII AKHLDNIHSL 300
    PLPLVERILT QTYSRTVSPR VESLRQYENG TDNVYGELLP RFISDIFKQT 350
    KLKSDQVFVD LGSGVGNVVL QAALEIGCES WGCEVMQNAC DVAELQGREF 400
    EARCRLWGLS PGIVRLIRGS FLTEESIIRA LHRADVVLIN NQAFTPQLNN 450
    EIINHFLDMK EGCQIVSLKS FVPAGHRIQA RNLNSPVNLL SVKQKNYWSG 500
    SFEA 504
    Length:504
    Mass (Da):56,224
    Last modified:August 21, 2007 - v1
    Checksum:i62995B72D0105CB8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476656 Genomic DNA. Translation: EDN06013.1.
    RefSeqiXP_001542445.1. XM_001542395.1.

    Genome annotation databases

    GeneIDi5449222.
    KEGGiaje:HCAG_02616.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476656 Genomic DNA. Translation: EDN06013.1 .
    RefSeqi XP_001542445.1. XM_001542395.1.

    3D structure databases

    ProteinModelPortali A6QZ09.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5449222.
    KEGGi aje:HCAG_02616.

    Phylogenomic databases

    KOi K11427.
    OrthoDBi EOG7KH9VN.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021162. Histone_H3-K79_MeTrfase_fungi.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF08123. DOT1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51569. DOT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NAm1 / WU24Imported.

    Entry informationi

    Entry nameiA6QZ09_AJECN
    AccessioniPrimary (citable) accession number: A6QZ09
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 21, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3