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A6QX86

- KEX1_AJECN

UniProt

A6QX86 - KEX1_AJECN

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene
KEX1, HCAG_01993
Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei185 – 1851 By similarity
Active sitei384 – 3841 By similarity
Active sitei446 – 4461 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:HCAG_01993
OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Taxonomic identifieri339724 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
ProteomesiUP000009297: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 517484Lumenal Reviewed predictionAdd
BLAST
Transmembranei518 – 53821Helical; Reviewed predictionAdd
BLAST
Topological domaini539 – 63496Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed predictionAdd
BLAST
Chaini34 – 634601Pheromone-processing carboxypeptidase KEX1PRO_0000411896Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi118 – 1181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi328 – 3281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi435 – 4351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi443 – 4431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi495 – 4951N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliA6QX86.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi560 – 5656Poly-Ser

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6QX86-1 [UniParc]FASTAAdd to Basket

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MGFSEARAYR AFGGRSTWLT VFLALANSLA VSAKCAADYF VDSLPGQPDS    50
PQVQMHAGHI EINHKTSANL FFWHVANQHI ADKPRTVIWL NGGPGCSSED 100
GALMEIGPYR VTNDHLLNHT DGSWDEFANL LFVDQPVGTG FSYVSTGAYV 150
SELGEMASQF VTFLEKWFEL FPHYEKNDLY FAGESYAGQY IPYIARAILD 200
RNKKGESLTR WKLKGILIGN GWISPRHQYL SYLPYAYQEG IIQGGTDSSS 250
RVEAKLSKCL NKLNVEDSTG TVQISACEEV LQAIIDETHK GNRCINMYDI 300
RLTDEYSACG MNWPPDLENM APYLRFKNVT KALHINSDKQ TGWSECSGAV 350
SGHFRALKSK PSVELLPGLL EEGLPILLFS GQKDMICNHI GNEDLIKDMK 400
WSGGTGFELS PGVWAPRQDW IFEGESAGFY QQARNLTYVL FYNASHMVPF 450
NYPPRSREML DRFIGVDIAD IGGNPADSRI DGEKGPATSV RAHPNSTAAA 500
EREKEKVKSA MWKAYYKSGE VALIVVAIAA VIWGVFIWRS RQKHQDRGYE 550
FRGIYPMLGS SSSGSLPRYS NKRGRRGHDV EAVNIYEAEL DERPSRVVSA 600
RSSREQEPYV VGDEDGSDVD DDTSDERKRL VDKP 634
Length:634
Mass (Da):70,866
Last modified:August 21, 2007 - v1
Checksum:i40C8F861DEA7CEBD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476655 Genomic DNA. Translation: EDN04128.1.
RefSeqiXP_001544946.1. XM_001544896.1.

Genome annotation databases

GeneIDi5449542.
KEGGiaje:HCAG_01993.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476655 Genomic DNA. Translation: EDN04128.1 .
RefSeqi XP_001544946.1. XM_001544896.1.

3D structure databases

ProteinModelPortali A6QX86.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5449542.
KEGGi aje:HCAG_01993.

Phylogenomic databases

KOi K01288.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NAm1 / WU24.

Entry informationi

Entry nameiKEX1_AJECN
AccessioniPrimary (citable) accession number: A6QX86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: August 21, 2007
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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