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A6QX86

- KEX1_AJECN

UniProt

A6QX86 - KEX1_AJECN

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei185 – 1851By similarity
    Active sitei384 – 3841By similarity
    Active sitei446 – 4461By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:HCAG_01993
    OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
    Taxonomic identifieri339724 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
    ProteomesiUP000009297: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 634601Pheromone-processing carboxypeptidase KEX1PRO_0000411896Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi328 – 3281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi435 – 4351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi443 – 4431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi495 – 4951N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliA6QX86.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini34 – 517484LumenalSequence AnalysisAdd
    BLAST
    Topological domaini539 – 63496CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei518 – 53821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi560 – 5656Poly-Ser

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK01288.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A6QX86-1 [UniParc]FASTAAdd to Basket

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    MGFSEARAYR AFGGRSTWLT VFLALANSLA VSAKCAADYF VDSLPGQPDS    50
    PQVQMHAGHI EINHKTSANL FFWHVANQHI ADKPRTVIWL NGGPGCSSED 100
    GALMEIGPYR VTNDHLLNHT DGSWDEFANL LFVDQPVGTG FSYVSTGAYV 150
    SELGEMASQF VTFLEKWFEL FPHYEKNDLY FAGESYAGQY IPYIARAILD 200
    RNKKGESLTR WKLKGILIGN GWISPRHQYL SYLPYAYQEG IIQGGTDSSS 250
    RVEAKLSKCL NKLNVEDSTG TVQISACEEV LQAIIDETHK GNRCINMYDI 300
    RLTDEYSACG MNWPPDLENM APYLRFKNVT KALHINSDKQ TGWSECSGAV 350
    SGHFRALKSK PSVELLPGLL EEGLPILLFS GQKDMICNHI GNEDLIKDMK 400
    WSGGTGFELS PGVWAPRQDW IFEGESAGFY QQARNLTYVL FYNASHMVPF 450
    NYPPRSREML DRFIGVDIAD IGGNPADSRI DGEKGPATSV RAHPNSTAAA 500
    EREKEKVKSA MWKAYYKSGE VALIVVAIAA VIWGVFIWRS RQKHQDRGYE 550
    FRGIYPMLGS SSSGSLPRYS NKRGRRGHDV EAVNIYEAEL DERPSRVVSA 600
    RSSREQEPYV VGDEDGSDVD DDTSDERKRL VDKP 634
    Length:634
    Mass (Da):70,866
    Last modified:August 21, 2007 - v1
    Checksum:i40C8F861DEA7CEBD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476655 Genomic DNA. Translation: EDN04128.1.
    RefSeqiXP_001544946.1. XM_001544896.1.

    Genome annotation databases

    GeneIDi5449542.
    KEGGiaje:HCAG_01993.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476655 Genomic DNA. Translation: EDN04128.1 .
    RefSeqi XP_001544946.1. XM_001544896.1.

    3D structure databases

    ProteinModelPortali A6QX86.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5449542.
    KEGGi aje:HCAG_01993.

    Phylogenomic databases

    KOi K01288.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NAm1 / WU24.

    Entry informationi

    Entry nameiKEX1_AJECN
    AccessioniPrimary (citable) accession number: A6QX86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3