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A6QR46

- RAB6B_BOVIN

UniProt

A6QR46 - RAB6B_BOVIN

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Protein

Ras-related protein Rab-6B

Gene

RAB6B

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451GTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 278GTPBy similarity
Nucleotide bindingi68 – 725GTPBy similarity
Nucleotide bindingi126 – 1294GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
  2. small GTPase mediated signal transduction Source: InterPro
  3. vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-6B
Gene namesi
Name:RAB6B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 1

Subcellular locationi

Golgi apparatus membrane By similarity; Lipid-anchor By similarity. Cytoplasmic vesicle By similarity
Note: Colocalizes with BICD1 at vesicular structures that align along microtubules.By similarity

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. Golgi apparatus Source: UniProtKB-KW
  3. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 208207Ras-related protein Rab-6BPRO_0000371507Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Lipidationi206 – 2061S-geranylgeranyl cysteineBy similarity
Modified residuei208 – 2081Cysteine methyl esterBy similarity
Lipidationi208 – 2081S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PRIDEiA6QR46.

Interactioni

Subunit structurei

Interacts with RAB6KIFL. Interacts (GTP-bound) with BICD1 (via C-terminus); the interaction is direct. Interacts (GDP-bound) with DYNLRB1. Interacts with CCDC64/BICDR1; leads to its accumulation in the pericentrosomal region (By similarity). Interacts (GTP-bound) with APBA1/MINT1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001199.

Structurei

3D structure databases

ProteinModelPortaliA6QR46.
SMRiA6QR46. Positions 13-174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 509Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00730000110423.
HOGENOMiHOG000233968.
InParanoidiA6QR46.
KOiK07894.
OMAiMESVQEK.
OrthoDBiEOG77DJ7M.
TreeFamiTF300803.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6QR46-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF
60 70 80 90 100
LSKTMYLEDR TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNLNS
110 120 130 140 150
FQQTSKWIDD VRTERGSDVI IMLVGNKTDL ADKRQITIEE GEQRAKELSV
160 170 180 190 200
MFIETSAKTG YNVKQLFRRV ASALPGMENV QEKSKEGMID IKLDKPQEPP

ASEGGCSC
Length:208
Mass (Da):23,462
Last modified:August 21, 2007 - v1
Checksum:iE81C831996E2446D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC150111 mRNA. Translation: AAI50112.1.
RefSeqiNP_001094599.1. NM_001101129.1.
UniGeneiBt.65157.

Genome annotation databases

EnsembliENSBTAT00000001199; ENSBTAP00000001199; ENSBTAG00000000905.
GeneIDi526526.
KEGGibta:526526.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC150111 mRNA. Translation: AAI50112.1 .
RefSeqi NP_001094599.1. NM_001101129.1.
UniGenei Bt.65157.

3D structure databases

ProteinModelPortali A6QR46.
SMRi A6QR46. Positions 13-174.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000001199.

Proteomic databases

PRIDEi A6QR46.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000001199 ; ENSBTAP00000001199 ; ENSBTAG00000000905 .
GeneIDi 526526.
KEGGi bta:526526.

Organism-specific databases

CTDi 51560.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00730000110423.
HOGENOMi HOG000233968.
InParanoidi A6QR46.
KOi K07894.
OMAi MESVQEK.
OrthoDBi EOG77DJ7M.
TreeFami TF300803.

Miscellaneous databases

NextBioi 20874388.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hippocampus.

Entry informationi

Entry nameiRAB6B_BOVIN
AccessioniPrimary (citable) accession number: A6QR46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3