Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A6QR46 (RAB6B_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-6B
Gene names
Name:RAB6B
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells By similarity.

Subunit structure

Interacts with RAB6KIFL. Interacts (GTP-bound) with BICD1 (via C-terminus); the interaction is direct. Interacts (GDP-bound) with DYNLRB1. Interacts with CCDC64/BICDR1; leads to its accumulation in the pericentrosomal region By similarity. Interacts (GTP-bound) with APBA1/MINT1 By similarity.

Subcellular location

Golgi apparatus membrane; Lipid-anchor By similarity. Cytoplasmic vesicle By similarity. Note: Colocalizes with BICD1 at vesicular structures that align along microtubules By similarity.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 208207Ras-related protein Rab-6B
PRO_0000371507

Regions

Nucleotide binding20 – 278GTP By similarity
Nucleotide binding68 – 725GTP By similarity
Nucleotide binding126 – 1294GTP By similarity
Motif42 – 509Effector region By similarity

Sites

Binding site451GTP By similarity

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue2081Cysteine methyl ester By similarity
Lipidation2061S-geranylgeranyl cysteine By similarity
Lipidation2081S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
A6QR46 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: E81C831996E2446D

FASTA20823,462
        10         20         30         40         50         60 
MSAGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF LSKTMYLEDR 

        70         80         90        100        110        120 
TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNLNS FQQTSKWIDD VRTERGSDVI 

       130        140        150        160        170        180 
IMLVGNKTDL ADKRQITIEE GEQRAKELSV MFIETSAKTG YNVKQLFRRV ASALPGMENV 

       190        200 
QEKSKEGMID IKLDKPQEPP ASEGGCSC 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Hippocampus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC150111 mRNA. Translation: AAI50112.1.
RefSeqNP_001094599.1. NM_001101129.1.
UniGeneBt.65157.

3D structure databases

ProteinModelPortalA6QR46.
SMRA6QR46. Positions 13-174.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000001199.

Proteomic databases

PRIDEA6QR46.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000001199; ENSBTAP00000001199; ENSBTAG00000000905.
GeneID526526.
KEGGbta:526526.

Organism-specific databases

CTD51560.

Phylogenomic databases

eggNOGCOG1100.
GeneTreeENSGT00730000110423.
HOGENOMHOG000233968.
InParanoidA6QR46.
KOK07894.
OMAMESVQEK.
OrthoDBEOG77DJ7M.
TreeFamTF300803.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20874388.

Entry information

Entry nameRAB6B_BOVIN
AccessionPrimary (citable) accession number: A6QR46
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: August 21, 2007
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families