A6QR34 (A6QR34_BOVIN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
GCK protein EMBL AAI50098.1

Submitted name:
Uncharacterized protein Ensembl ENSBTAP00000043100

Gene names

Name:

GCK Ensembl ENSBTAP00000043100 EMBL AAI50098.1

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the hexokinase family. RuleBase RU004510

Ontologies

Keywords
Biological process	Glycolysis RuleBase RU004049 SAAS SAAS022672
Ligand	ATP-binding RuleBase RU004049 SAAS SAAS022672 Nucleotide-binding
Molecular function	Kinase RuleBase RU004049 SAAS SAAS022672 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	NADP metabolic process Inferred from electronic annotation. Source: Compara calcium ion import Inferred from electronic annotation. Source: Compara cellular glucose homeostasis Inferred from Biological aspect of Ancestor. Source: RefGenome detection of glucose Inferred from electronic annotation. Source: Compara glycolysis Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of gluconeogenesis Inferred from electronic annotation. Source: Compara positive regulation of glycogen biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of insulin secretion Inferred from electronic annotation. Source: Compara regulation of insulin secretion Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of potassium ion transport Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Inferred from Biological aspect of Ancestor. Source: RefGenome mitochondrion Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glucokinase activity Inferred from Biological aspect of Ancestor. Source: RefGenome glucose binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A6QR34 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 821AB8CB1A98A8A3	FASTA	465	52,204
	10 20 30 40 50 60 MLDDRARMEI SKKEKAEQIL AEFQLQEEDL KKVMRRMQKE MDRGLRLETH KEASVKMLPT 70 80 90 100 110 120 YVRSTPEGSE VGDFLSLDLG GTNFRVMLVK VGEGEAGQWS VKTTHQMYSI PEDAMTGTAE 130 140 150 160 170 180 MLFDYISECI SDFLDKHQMK HKKLPLGFTF SFPVRHEDID KGILLNWTKG FKASGAEGNN 190 200 210 220 230 240 IVGLLRDAIK RRGDFEMDVV AMVNDTVATM ISCYYEDRRC EVGMIVGTGC NACYMEEMQN 250 260 270 280 290 300 VELVEGDEGR MCVNTEWGAF GDSGELDEFL LEYDRVVDEN SLNPGQQLYE KLIGGKYMGE 310 320 330 340 350 360 LVRLVLLKLV DENLLFHGEA SEQLRTRGAF ETRFVSQVES DSGDRKQIYN ILSTLGLRPS 370 380 390 400 410 420 ATDCDIVRRA CESVSTRAAH MCAAGLAGVI NRMRESRSED VMRITVGVDG SVYKLHPSFK 430 440 450 460 ERFHAIVRRL TPSCEITFIE SEEGSGRGAA LISAVACKKA CMLGQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y., Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C., Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J. , Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J., Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A., Holt R., Jones S.J., Marra M.A. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: L1 Hereford EMBL AAI50098.1. Tissue: Uterus EMBL AAI50098.1.
[2]	"A whole-genome assembly of the domestic cow, Bos taurus." Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L. Genome Biol. 10:R42-R42(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hereford Ensembl ENSBTAP00000043100.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: Hereford Ensembl ENSBTAP00000043100.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DAAA02011181 Genomic DNA. No translation available. BC150097 mRNA. Translation: AAI50098.1.
IPI	IPI00867031.
RefSeq	NP_001095772.1. NM_001102302.1.
UniGene	Bt.44137.
3D structure databases
SMR	A6QR34. Positions 17-461.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000043100.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000045734; ENSBTAP00000043100; ENSBTAG00000032288.
GeneID	616576.
KEGG	bta:616576.
Organism-specific databases
CTD	2645.
Phylogenomic databases
eggNOG	COG5026.
GeneTree	ENSGT00390000017159.
HOGENOM	HOG000162670.
HOVERGEN	HBG000142.
InParanoid	A6QR34.
KO	K12407.
OMA	ISGKYMG.
OrthoDB	EOG4N5VWR.
Family and domain databases
InterPro	IPR001312. Hexokinase. IPR022673. Hexokinase_C. IPR019807. Hexokinase_CS. IPR022672. Hexokinase_N. [Graphical view]
PANTHER	PTHR19443. PTHR19443. 1 hit.
Pfam	PF00349. Hexokinase_1. 1 hit. PF03727. Hexokinase_2. 1 hit. [Graphical view]
PRINTS	PR00475. HEXOKINASE.
PROSITE	PS00378. HEXOKINASES. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20900200.

Entry information

Entry name

A6QR34_BOVIN

Accession

Primary (citable) accession number: A6QR34

Entry history

Integrated into UniProtKB/TrEMBL:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	April 3, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)