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A6QR11

- NELL2_BOVIN

UniProt

A6QR11 - NELL2_BOVIN

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Protein
Protein kinase C-binding protein NELL2
Gene
NELL2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-binding protein NELL2
Alternative name(s):
NEL-like protein 2
Gene namesi
Name:NELL2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 5

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 816795Protein kinase C-binding protein NELL2
PRO_0000354681Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi225 – 2251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi293 – 2931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi298 – 2981N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi401 ↔ 413 By similarity
Disulfide bondi407 ↔ 422 By similarity
Disulfide bondi424 ↔ 438 By similarity
Disulfide bondi444 ↔ 457 By similarity
Disulfide bondi451 ↔ 466 By similarity
Disulfide bondi468 ↔ 480 By similarity
Disulfide bondi486 ↔ 499 By similarity
Disulfide bondi493 ↔ 508 By similarity
Disulfide bondi510 ↔ 521 By similarity
Glycosylationi517 – 5171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi525 ↔ 535 By similarity
Disulfide bondi529 ↔ 541 By similarity
Disulfide bondi543 ↔ 552 By similarity
Disulfide bondi559 ↔ 572 By similarity
Disulfide bondi566 ↔ 581 By similarity
Disulfide bondi583 ↔ 600 By similarity
Disulfide bondi606 ↔ 619 By similarity
Disulfide bondi613 ↔ 628 By similarity
Glycosylationi615 – 6151N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi630 ↔ 636 By similarity
Glycosylationi635 – 6351N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homotrimer. Binds to PKC beta-1 By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042993.

Structurei

3D structure databases

ProteinModelPortaliA6QR11.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 258229Laminin G-like
Add
BLAST
Domaini272 – 33160VWFC 1
Add
BLAST
Domaini397 – 43943EGF-like 1
Add
BLAST
Domaini440 – 48142EGF-like 2; calcium-binding Reviewed prediction
Add
BLAST
Domaini482 – 52241EGF-like 3; calcium-binding Reviewed prediction
Add
BLAST
Domaini523 – 55331EGF-like 4
Add
BLAST
Domaini555 – 60147EGF-like 5; calcium-binding Reviewed prediction
Add
BLAST
Domaini602 – 63736EGF-like 6; calcium-binding Reviewed prediction
Add
BLAST
Domaini638 – 69356VWFC 2
Add
BLAST
Domaini698 – 75659VWFC 3
Add
BLAST

Sequence similaritiesi

Contains 6 EGF-like domains.
Contains 3 VWFC domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG253557.
GeneTreeiENSGT00750000117321.
HOGENOMiHOG000217920.
HOVERGENiHBG004805.
InParanoidiA6QR11.
OMAiDTICFNL.
OrthoDBiEOG71VSRX.
TreeFamiTF323325.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR026823. cEGF.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 1 hit.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6QR11-1 [UniParc]FASTAAdd to Basket

« Hide

MESRVLLRTF CLLFGLGAVW GLGVDPSLQI DVLTELELGE STTGVRQVPG    50
LHNGTKAFLF QDTPRSIKAS TATAEQFFQK LRNKHEFTIL VTLKQTHLNS 100
GVILSIHHLD HRYLELESSG HRNEVRLHYR SGSHHPHTEV FPYILADDKW 150
HKLSLAISAS HLILHIDCNK IYERVVEKPS TDLPLGTSFW LGQRNNAHGY 200
FKGIMQDVQL LVMPQGFIAQ CPDLNRTCPT CNDFHGLVQK IMELQDILAK 250
TSAKLSRAEQ RMNRLDQCYC ERTCTMKGTT YREFESWTDG CKNCTCLNGT 300
IQCETLICPN PDCPLKSAPA YVDGKCCKEC KSICQFQGRT YFEGQRNTVY 350
SSSGVCVLYE CKDQSMKLVE SSGCPALDCA ESHQITLSHS CCKVCKGYDF 400
CSERHNCMEN SVCRNLNDRA VCSCRDGFRA LREDNAYCED IDECAEGRHY 450
CRENTMCVNT PGSFMCICKT GYIRIDDYSC TEHDECVTNQ HNCDENALCF 500
NTVGGHNCVC KPGYTGNGTT CKAFCQDGCR NGGACIAANV CACPQGFTGH 550
SCETDIDECS DGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFSPSGESC 600
EDIDECGTGR HSCANDTICF NLDGGYDCRC PHGKNCTGDC IHDGKIKHNG 650
QIWVLENDRC SVCSCQNGFV MCRRMVCDCE NPTVDLFCCP ECDPRLSSQC 700
LHQNGETLYN SGDTWVQNCQ QCRCLQGEVD CWPLPCPEVE CEFSVLPENE 750
CCPRCVTDPC QADTIRNDIT KTCLDEMNVV RFTGSSWIKH GTECTLCQCK 800
NGHICCSVDP QCLQEL 816
Length:816
Mass (Da):91,270
Last modified:August 21, 2007 - v1
Checksum:iAA3407C610A18819
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC150070 mRNA. Translation: AAI50071.1.
RefSeqiNP_001095554.1. NM_001102084.1.
XP_005206438.1. XM_005206381.1.
XP_005206439.1. XM_005206382.1.
XP_005206440.1. XM_005206383.1.
UniGeneiBt.8804.

Genome annotation databases

EnsembliENSBTAT00000045616; ENSBTAP00000042993; ENSBTAG00000032183.
GeneIDi524622.
KEGGibta:524622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC150070 mRNA. Translation: AAI50071.1 .
RefSeqi NP_001095554.1. NM_001102084.1.
XP_005206438.1. XM_005206381.1.
XP_005206439.1. XM_005206382.1.
XP_005206440.1. XM_005206383.1.
UniGenei Bt.8804.

3D structure databases

ProteinModelPortali A6QR11.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000042993.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000045616 ; ENSBTAP00000042993 ; ENSBTAG00000032183 .
GeneIDi 524622.
KEGGi bta:524622.

Organism-specific databases

CTDi 4753.

Phylogenomic databases

eggNOGi NOG253557.
GeneTreei ENSGT00750000117321.
HOGENOMi HOG000217920.
HOVERGENi HBG004805.
InParanoidi A6QR11.
OMAi DTICFNL.
OrthoDBi EOG71VSRX.
TreeFami TF323325.

Miscellaneous databases

NextBioi 20874000.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR026823. cEGF.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF12662. cEGF. 1 hit.
PF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 1 hit.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 2 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hippocampus.

Entry informationi

Entry nameiNELL2_BOVIN
AccessioniPrimary (citable) accession number: A6QR11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: August 21, 2007
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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