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A6QR11

- NELL2_BOVIN

UniProt

A6QR11 - NELL2_BOVIN

Protein

Protein kinase C-binding protein NELL2

Gene

NELL2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein kinase C-binding protein NELL2
    Alternative name(s):
    NEL-like protein 2
    Gene namesi
    Name:NELL2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 5

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 816795Protein kinase C-binding protein NELL2PRO_0000354681Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi401 ↔ 413PROSITE-ProRule annotation
    Disulfide bondi407 ↔ 422PROSITE-ProRule annotation
    Disulfide bondi424 ↔ 438PROSITE-ProRule annotation
    Disulfide bondi444 ↔ 457PROSITE-ProRule annotation
    Disulfide bondi451 ↔ 466PROSITE-ProRule annotation
    Disulfide bondi468 ↔ 480PROSITE-ProRule annotation
    Disulfide bondi486 ↔ 499PROSITE-ProRule annotation
    Disulfide bondi493 ↔ 508PROSITE-ProRule annotation
    Disulfide bondi510 ↔ 521PROSITE-ProRule annotation
    Glycosylationi517 – 5171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi525 ↔ 535PROSITE-ProRule annotation
    Disulfide bondi529 ↔ 541PROSITE-ProRule annotation
    Disulfide bondi543 ↔ 552PROSITE-ProRule annotation
    Disulfide bondi559 ↔ 572PROSITE-ProRule annotation
    Disulfide bondi566 ↔ 581PROSITE-ProRule annotation
    Disulfide bondi583 ↔ 600PROSITE-ProRule annotation
    Disulfide bondi606 ↔ 619PROSITE-ProRule annotation
    Disulfide bondi613 ↔ 628PROSITE-ProRule annotation
    Glycosylationi615 – 6151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi630 ↔ 636PROSITE-ProRule annotation
    Glycosylationi635 – 6351N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Homotrimer. Binds to PKC beta-1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000042993.

    Structurei

    3D structure databases

    ProteinModelPortaliA6QR11.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 258229Laminin G-likeAdd
    BLAST
    Domaini272 – 33160VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini397 – 43943EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini440 – 48142EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini482 – 52241EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini523 – 55331EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini555 – 60147EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini602 – 63736EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini638 – 69356VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini698 – 75659VWFC 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 6 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.Curated
    Contains 3 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG253557.
    GeneTreeiENSGT00750000117321.
    HOGENOMiHOG000217920.
    HOVERGENiHBG004805.
    InParanoidiA6QR11.
    OMAiDTICFNL.
    OrthoDBiEOG71VSRX.
    TreeFamiTF323325.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR026823. cEGF.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR024731. EGF_dom_MSP1-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF12662. cEGF. 1 hit.
    PF12947. EGF_3. 1 hit.
    PF07645. EGF_CA. 1 hit.
    PF02210. Laminin_G_2. 1 hit.
    PF00093. VWC. 2 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 2 hits.
    SM00179. EGF_CA. 3 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 3 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 4 hits.
    PS50026. EGF_3. 6 hits.
    PS01187. EGF_CA. 3 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A6QR11-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESRVLLRTF CLLFGLGAVW GLGVDPSLQI DVLTELELGE STTGVRQVPG    50
    LHNGTKAFLF QDTPRSIKAS TATAEQFFQK LRNKHEFTIL VTLKQTHLNS 100
    GVILSIHHLD HRYLELESSG HRNEVRLHYR SGSHHPHTEV FPYILADDKW 150
    HKLSLAISAS HLILHIDCNK IYERVVEKPS TDLPLGTSFW LGQRNNAHGY 200
    FKGIMQDVQL LVMPQGFIAQ CPDLNRTCPT CNDFHGLVQK IMELQDILAK 250
    TSAKLSRAEQ RMNRLDQCYC ERTCTMKGTT YREFESWTDG CKNCTCLNGT 300
    IQCETLICPN PDCPLKSAPA YVDGKCCKEC KSICQFQGRT YFEGQRNTVY 350
    SSSGVCVLYE CKDQSMKLVE SSGCPALDCA ESHQITLSHS CCKVCKGYDF 400
    CSERHNCMEN SVCRNLNDRA VCSCRDGFRA LREDNAYCED IDECAEGRHY 450
    CRENTMCVNT PGSFMCICKT GYIRIDDYSC TEHDECVTNQ HNCDENALCF 500
    NTVGGHNCVC KPGYTGNGTT CKAFCQDGCR NGGACIAANV CACPQGFTGH 550
    SCETDIDECS DGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFSPSGESC 600
    EDIDECGTGR HSCANDTICF NLDGGYDCRC PHGKNCTGDC IHDGKIKHNG 650
    QIWVLENDRC SVCSCQNGFV MCRRMVCDCE NPTVDLFCCP ECDPRLSSQC 700
    LHQNGETLYN SGDTWVQNCQ QCRCLQGEVD CWPLPCPEVE CEFSVLPENE 750
    CCPRCVTDPC QADTIRNDIT KTCLDEMNVV RFTGSSWIKH GTECTLCQCK 800
    NGHICCSVDP QCLQEL 816
    Length:816
    Mass (Da):91,270
    Last modified:August 21, 2007 - v1
    Checksum:iAA3407C610A18819
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC150070 mRNA. Translation: AAI50071.1.
    RefSeqiNP_001095554.1. NM_001102084.1.
    XP_005206438.1. XM_005206381.1.
    XP_005206439.1. XM_005206382.1.
    XP_005206440.1. XM_005206383.1.
    UniGeneiBt.8804.

    Genome annotation databases

    EnsembliENSBTAT00000045616; ENSBTAP00000042993; ENSBTAG00000032183.
    GeneIDi524622.
    KEGGibta:524622.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC150070 mRNA. Translation: AAI50071.1 .
    RefSeqi NP_001095554.1. NM_001102084.1.
    XP_005206438.1. XM_005206381.1.
    XP_005206439.1. XM_005206382.1.
    XP_005206440.1. XM_005206383.1.
    UniGenei Bt.8804.

    3D structure databases

    ProteinModelPortali A6QR11.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000042993.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000045616 ; ENSBTAP00000042993 ; ENSBTAG00000032183 .
    GeneIDi 524622.
    KEGGi bta:524622.

    Organism-specific databases

    CTDi 4753.

    Phylogenomic databases

    eggNOGi NOG253557.
    GeneTreei ENSGT00750000117321.
    HOGENOMi HOG000217920.
    HOVERGENi HBG004805.
    InParanoidi A6QR11.
    OMAi DTICFNL.
    OrthoDBi EOG71VSRX.
    TreeFami TF323325.

    Miscellaneous databases

    NextBioi 20874000.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR026823. cEGF.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR024731. EGF_dom_MSP1-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF12662. cEGF. 1 hit.
    PF12947. EGF_3. 1 hit.
    PF07645. EGF_CA. 1 hit.
    PF02210. Laminin_G_2. 1 hit.
    PF00093. VWC. 2 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 2 hits.
    SM00179. EGF_CA. 3 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 4 hits.
    PS50026. EGF_3. 6 hits.
    PS01187. EGF_CA. 3 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiNELL2_BOVIN
    AccessioniPrimary (citable) accession number: A6QR11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3