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A6QR11

- NELL2_BOVIN

UniProt

A6QR11 - NELL2_BOVIN

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Protein

Protein kinase C-binding protein NELL2

Gene

NELL2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-binding protein NELL2
Alternative name(s):
NEL-like protein 2
Gene namesi
Name:NELL2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 5

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 816795Protein kinase C-binding protein NELL2PRO_0000354681Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi401 ↔ 413PROSITE-ProRule annotation
Disulfide bondi407 ↔ 422PROSITE-ProRule annotation
Disulfide bondi424 ↔ 438PROSITE-ProRule annotation
Disulfide bondi444 ↔ 457PROSITE-ProRule annotation
Disulfide bondi451 ↔ 466PROSITE-ProRule annotation
Disulfide bondi468 ↔ 480PROSITE-ProRule annotation
Disulfide bondi486 ↔ 499PROSITE-ProRule annotation
Disulfide bondi493 ↔ 508PROSITE-ProRule annotation
Disulfide bondi510 ↔ 521PROSITE-ProRule annotation
Glycosylationi517 – 5171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi525 ↔ 535PROSITE-ProRule annotation
Disulfide bondi529 ↔ 541PROSITE-ProRule annotation
Disulfide bondi543 ↔ 552PROSITE-ProRule annotation
Disulfide bondi559 ↔ 572PROSITE-ProRule annotation
Disulfide bondi566 ↔ 581PROSITE-ProRule annotation
Disulfide bondi583 ↔ 600PROSITE-ProRule annotation
Disulfide bondi606 ↔ 619PROSITE-ProRule annotation
Disulfide bondi613 ↔ 628PROSITE-ProRule annotation
Glycosylationi615 – 6151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi630 ↔ 636PROSITE-ProRule annotation
Glycosylationi635 – 6351N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homotrimer. Binds to PKC beta-1 By similarity.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042993.

Structurei

3D structure databases

ProteinModelPortaliA6QR11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 258229Laminin G-likeAdd
BLAST
Domaini272 – 33160VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini397 – 43943EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini440 – 48142EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini482 – 52241EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini523 – 55331EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini555 – 60147EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini602 – 63736EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini638 – 69356VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini698 – 75659VWFC 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.Curated
Contains 3 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG253557.
GeneTreeiENSGT00750000117321.
HOGENOMiHOG000217920.
HOVERGENiHBG004805.
InParanoidiA6QR11.
OMAiDTICFNL.
OrthoDBiEOG71VSRX.
TreeFamiTF323325.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR026823. cEGF.
IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 1 hit.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6QR11-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESRVLLRTF CLLFGLGAVW GLGVDPSLQI DVLTELELGE STTGVRQVPG
60 70 80 90 100
LHNGTKAFLF QDTPRSIKAS TATAEQFFQK LRNKHEFTIL VTLKQTHLNS
110 120 130 140 150
GVILSIHHLD HRYLELESSG HRNEVRLHYR SGSHHPHTEV FPYILADDKW
160 170 180 190 200
HKLSLAISAS HLILHIDCNK IYERVVEKPS TDLPLGTSFW LGQRNNAHGY
210 220 230 240 250
FKGIMQDVQL LVMPQGFIAQ CPDLNRTCPT CNDFHGLVQK IMELQDILAK
260 270 280 290 300
TSAKLSRAEQ RMNRLDQCYC ERTCTMKGTT YREFESWTDG CKNCTCLNGT
310 320 330 340 350
IQCETLICPN PDCPLKSAPA YVDGKCCKEC KSICQFQGRT YFEGQRNTVY
360 370 380 390 400
SSSGVCVLYE CKDQSMKLVE SSGCPALDCA ESHQITLSHS CCKVCKGYDF
410 420 430 440 450
CSERHNCMEN SVCRNLNDRA VCSCRDGFRA LREDNAYCED IDECAEGRHY
460 470 480 490 500
CRENTMCVNT PGSFMCICKT GYIRIDDYSC TEHDECVTNQ HNCDENALCF
510 520 530 540 550
NTVGGHNCVC KPGYTGNGTT CKAFCQDGCR NGGACIAANV CACPQGFTGH
560 570 580 590 600
SCETDIDECS DGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFSPSGESC
610 620 630 640 650
EDIDECGTGR HSCANDTICF NLDGGYDCRC PHGKNCTGDC IHDGKIKHNG
660 670 680 690 700
QIWVLENDRC SVCSCQNGFV MCRRMVCDCE NPTVDLFCCP ECDPRLSSQC
710 720 730 740 750
LHQNGETLYN SGDTWVQNCQ QCRCLQGEVD CWPLPCPEVE CEFSVLPENE
760 770 780 790 800
CCPRCVTDPC QADTIRNDIT KTCLDEMNVV RFTGSSWIKH GTECTLCQCK
810
NGHICCSVDP QCLQEL
Length:816
Mass (Da):91,270
Last modified:August 21, 2007 - v1
Checksum:iAA3407C610A18819
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC150070 mRNA. Translation: AAI50071.1.
RefSeqiNP_001095554.1. NM_001102084.1.
XP_005206438.1. XM_005206381.1.
XP_005206439.1. XM_005206382.1.
XP_005206440.1. XM_005206383.1.
UniGeneiBt.8804.

Genome annotation databases

EnsembliENSBTAT00000045616; ENSBTAP00000042993; ENSBTAG00000032183.
GeneIDi524622.
KEGGibta:524622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC150070 mRNA. Translation: AAI50071.1 .
RefSeqi NP_001095554.1. NM_001102084.1.
XP_005206438.1. XM_005206381.1.
XP_005206439.1. XM_005206382.1.
XP_005206440.1. XM_005206383.1.
UniGenei Bt.8804.

3D structure databases

ProteinModelPortali A6QR11.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000042993.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000045616 ; ENSBTAP00000042993 ; ENSBTAG00000032183 .
GeneIDi 524622.
KEGGi bta:524622.

Organism-specific databases

CTDi 4753.

Phylogenomic databases

eggNOGi NOG253557.
GeneTreei ENSGT00750000117321.
HOGENOMi HOG000217920.
HOVERGENi HBG004805.
InParanoidi A6QR11.
OMAi DTICFNL.
OrthoDBi EOG71VSRX.
TreeFami TF323325.

Miscellaneous databases

NextBioi 20874000.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR026823. cEGF.
IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF12662. cEGF. 1 hit.
PF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 1 hit.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 2 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hippocampus.

Entry informationi

Entry nameiNELL2_BOVIN
AccessioniPrimary (citable) accession number: A6QR11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3